Ribosomal protein L23
From Proteopedia
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| - | + | <StructureSection load='1n88' size='350' side='right' scene='' caption='Ribosomal protein L23 NMR structure (PDB code [[1n88]])'> | |
| - | + | == Function == | |
| - | '''Ribosomal protein L23''' (RPL23) is one of the 34 proteins which belong to the large 50S subunit of the prokaryotic ribosome or to the ca. 49 proteins in the large 60S subunit of the eukaryotic ribosome. RPL23 binds to 23S or 26S RRNA. | + | '''Ribosomal protein L23''' (RPL23) is one of the 34 proteins which belong to the large 50S subunit of the prokaryotic ribosome or to the ca. 49 proteins in the large 60S subunit of the eukaryotic ribosome. RPL23 binds to 23S or 26S RRNA<ref>PMID:15314173</ref>. |
| + | == Relevance == | ||
| + | RPL23 promotes multi drug resistance in gastric cancer cells<ref>PMID:15149863</ref>. | ||
| + | </StructureSection> | ||
== 3D Structures of Ribosomal protein L23 == | == 3D Structures of Ribosomal protein L23 == | ||
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*Ribosomal protein L23 | *Ribosomal protein L23 | ||
| - | **[[1n88]] – TtRPL23 – NMR - ''Thermus thermophilus'' | + | **[[1n88]] – TtRPL23 – NMR - ''Thermus thermophilus''<br /> |
| + | **[[6fu8]] – EcRPL23 - ''Escherichia coli'' – Cryo EM<br /> | ||
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| + | *L23 in part of 50S ribosome | ||
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| + | **[[2aar]] – DrRPL23 + RPL29 + 23S RRNA + trigger factor N terminal – ''Deinococcus radiodurans''<br /> | ||
| + | **[[2d3o]] – DrRPL23 + RPL24 + RPL29 + 23S RRNA + trigger factor N terminal <br /> | ||
| + | **[[2vrh]] – EcRPL23 + RPL24 + RPL29 + trigger factor – Cryo EM<br /> | ||
*Ribosomal protein L23 in part of 80S ribosome | *Ribosomal protein L23 in part of 80S ribosome | ||
**[[2ww9]], [[2wwa]] – yRPL23+RPL4+RPL17+RPL19+RPL25+RPL26+RPL31+RPL34+RPL35+RPL39+25S RRNA+SSH1P+SSS1+SEB2 – yeast - Cryo EM<br /> | **[[2ww9]], [[2wwa]] – yRPL23+RPL4+RPL17+RPL19+RPL25+RPL26+RPL31+RPL34+RPL35+RPL39+25S RRNA+SSH1P+SSS1+SEB2 – yeast - Cryo EM<br /> | ||
| + | **[[2x7n]] - yRPL23+RPL24 + sarcin-ricin loop + EIF-6 - Cryo EM<br /> | ||
**[[2wwb]] - wRPL23+RPL4+RPL17+RPL19+RPL25+RPL26+RPL31+RPL35+RPL39+25S RRNA+5.8S RRNA+ dSEBC61 – wheat - Cryo EM<br /> | **[[2wwb]] - wRPL23+RPL4+RPL17+RPL19+RPL25+RPL26+RPL31+RPL35+RPL39+25S RRNA+5.8S RRNA+ dSEBC61 – wheat - Cryo EM<br /> | ||
**[[2j37]] - wRPL23+RPL35+RPL31 + signal recognition particle + SRP RNA Cryo EM<br /> | **[[2j37]] - wRPL23+RPL35+RPL31 + signal recognition particle + SRP RNA Cryo EM<br /> | ||
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*Ribosomal protein L23 in part of 60S ribosome | *Ribosomal protein L23 in part of 60S ribosome | ||
| - | **[[3j46]], [[3j45]] - EcRPL23+RPL1+RPL24+RPL29+23S RRNA+ SECE + SECG + SECY + NC100 + A-tRNA + P-tRNA | + | **[[3j46]], [[3j45]] - EcRPL23+RPL1+RPL24+RPL29+23S RRNA+ SECE + SECG + SECY + NC100 + A-tRNA + P-tRNA - Cryo EM<br /> |
}} | }} | ||
| + | == References == | ||
| + | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
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3D Structures of Ribosomal protein L23
Updated on 29-December-2019
References
- ↑ Dai MS, Zeng SX, Jin Y, Sun XX, David L, Lu H. Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition. Mol Cell Biol. 2004 Sep;24(17):7654-68. PMID:15314173 doi:http://dx.doi.org/10.1128/MCB.24.17.7654-7668.2004
- ↑ Shi Y, Zhai H, Wang X, Han Z, Liu C, Lan M, Du J, Guo C, Zhang Y, Wu K, Fan D. Ribosomal proteins S13 and L23 promote multidrug resistance in gastric cancer cells by suppressing drug-induced apoptosis. Exp Cell Res. 2004 Jun 10;296(2):337-46. PMID:15149863 doi:http://dx.doi.org/10.1016/j.yexcr.2004.02.009
