Carbonyl reductase

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{{STRUCTURE_1cyd| PDB=1cyd | SIZE=400| SCENE= |right|CAPTION=Mouse carbonyl reductase tetramer complex with 2-propanol and NADPH, [[1cyd]] }}
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<StructureSection load='1cyd' size='350' side='right' scene='48/489333/Cv/4' caption='Mouse carbonyl reductase tetramer complex with 2-propanol and NADPH, [[1cyd]]'>
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'''Carbonyl reductase''' (CBR) catalyzes the reaction converting R-CHOH-R and NADP to R-CO-R’ and NADPH. CBR has wide substrate specificity oxidoreductase activity. CBR has similar properties to aldose reductase and aldehyde reductase.
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*'''(R)-specific carbonyl reductase''' yields (R)-alcohols and its cofactor is Zn+2 ion.<ref>PMID:11154733</ref>
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*<scene name='48/489333/Cv/9'>Active site</scene> of mouse carbonyl reductase ([[1cyd]]).<ref>PMID:8805511</ref>
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'''Carbonyl reductase''' (CBR) catalyzes the reaction converting R-CHOH-R and NADP to R-CO-R’ and NADPH. CBR has wide substrate specificity oxidoreductase activity. CBR has similar properties to aldose reductase and aldehyde reductase. (R)-specific carbonyl reductase cofactor is Zn+2 ion.
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==3D structures of carbonyl reductase==
==3D structures of carbonyl reductase==
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[[Carbonyl reductase 3D structures]]
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</StructureSection>
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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== References ==
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{{#tree:id=OrganizedByTopic|openlevels=0|
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<references/>
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*Carbonyl reductase
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**[[1zze]] – CBR – ''Sporidiobolus salmonicolor''<BR />
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**[[3afm]] – SpCBR – ''Sphingomonas''<br />
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**[[4w7h]] – SpCBR (mutant)<br />
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*(R)-specific carbonyl reductase
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**[[3ctm]], [[4oaq]] – CpCBR – ''Candida parapsilosis''<br />
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**[[4oaq]] – CpCBR + Zn<br />
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**[[3wle]], [[4c4o]] – CpCBR + NAD + Zn<br />
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**[[3wlf]] – CpCBR + phenylethane diol + Zn<br />
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**[[3wnq]] – CpCBR (mutant) + hydroxyacetophenone + Zn<br />
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*Carbonyl reductase binary complex with NADPH
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**[[3bhi]] - hCBR1 + NADPH - human<BR />
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**[[2hrb]] – hCBR3 + NADPH<BR />
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**[[3afn]] – SpCBR + NADP<br />
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*Carbonyl reductase ternary complex with NADPH
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**[[1cyd]] – CBR + 2-propanol + NADPH – mouse<BR />
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**[[1wma]] – hCBR1 + hydroxyl-PP + NADPH<BR />
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**[[2pfg]] - hCBR1 + bicycle-undecane + NADPH<BR />
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**[[3bhj]] - hCBR1 + glutathione + NADPH<BR />
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**[[3bhm]] - hCBR1 + hydroxymethylglutathione + NADPH<BR />
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}}
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[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Mouse carbonyl reductase tetramer complex with 2-propanol and NADPH, 1cyd

Drag the structure with the mouse to rotate

References

  1. ↑ Forrest GL, Gonzalez B. Carbonyl reductase. Chem Biol Interact. 2000 Dec 1;129(1-2):21-40. PMID:11154733
  2. ↑ Tanaka N, Nonaka T, Nakanishi M, Deyashiki Y, Hara A, Mitsui Y. Crystal structure of the ternary complex of mouse lung carbonyl reductase at 1.8 A resolution: the structural origin of coenzyme specificity in the short-chain dehydrogenase/reductase family. Structure. 1996 Jan 15;4(1):33-45. PMID:8805511

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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