Carbonyl reductase
From Proteopedia
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| - | <StructureSection load='1cyd' size=' | + | <StructureSection load='1cyd' size='350' side='right' scene='48/489333/Cv/4' caption='Mouse carbonyl reductase tetramer complex with 2-propanol and NADPH, [[1cyd]]'> |
| - | '''Carbonyl reductase''' (CBR) catalyzes the reaction converting R-CHOH-R and NADP to R-CO-R’ and NADPH. CBR has wide substrate specificity oxidoreductase activity. CBR has similar properties to aldose reductase and aldehyde reductase. (R)-specific carbonyl reductase cofactor is Zn+2 ion. | + | '''Carbonyl reductase''' (CBR) catalyzes the reaction converting R-CHOH-R and NADP to R-CO-R’ and NADPH. CBR has wide substrate specificity oxidoreductase activity. CBR has similar properties to aldose reductase and aldehyde reductase. |
| + | *'''(R)-specific carbonyl reductase''' yields (R)-alcohols and its cofactor is Zn+2 ion.<ref>PMID:11154733</ref> | ||
| + | *<scene name='48/489333/Cv/9'>Active site</scene> of mouse carbonyl reductase ([[1cyd]]).<ref>PMID:8805511</ref> | ||
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| + | ==3D structures of carbonyl reductase== | ||
| + | [[Carbonyl reductase 3D structures]] | ||
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</StructureSection> | </StructureSection> | ||
| - | ==3D structures of carbonyl reductase== | ||
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| - | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
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| - | *Carbonyl reductase | ||
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| - | **[[1zze]] – CBR – ''Sporidiobolus salmonicolor''<BR /> | ||
| - | **[[3afm]] – SpCBR – ''Sphingomonas''<br /> | ||
| - | **[[4w7h]] – SpCBR (mutant)<br /> | ||
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| - | *(R)-specific carbonyl reductase | ||
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| - | **[[3ctm]], [[4oaq]] – CpCBR – ''Candida parapsilosis''<br /> | ||
| - | **[[4oaq]] – CpCBR + Zn<br /> | ||
| - | **[[3wle]], [[4c4o]] – CpCBR + NAD + Zn<br /> | ||
| - | **[[3wlf]] – CpCBR + phenylethane diol + Zn<br /> | ||
| - | **[[3wnq]] – CpCBR (mutant) + hydroxyacetophenone + Zn<br /> | ||
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| - | *Carbonyl reductase binary complex with NADPH | ||
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| - | **[[3bhi]] - hCBR1 + NADPH - human<BR /> | ||
| - | **[[2hrb]] – hCBR3 + NADPH<BR /> | ||
| - | **[[3afn]] – SpCBR + NADP<br /> | ||
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| - | *Carbonyl reductase ternary complex with NADPH | ||
| - | + | == References == | |
| - | + | <references/> | |
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[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
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References
- ↑ Forrest GL, Gonzalez B. Carbonyl reductase. Chem Biol Interact. 2000 Dec 1;129(1-2):21-40. PMID:11154733
- ↑ Tanaka N, Nonaka T, Nakanishi M, Deyashiki Y, Hara A, Mitsui Y. Crystal structure of the ternary complex of mouse lung carbonyl reductase at 1.8 A resolution: the structural origin of coenzyme specificity in the short-chain dehydrogenase/reductase family. Structure. 1996 Jan 15;4(1):33-45. PMID:8805511
