Chloramphenicol acetyltransferase

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (10:06, 8 May 2019) (edit) (undo)
 
(10 intermediate revisions not shown.)
Line 1: Line 1:
-
<StructureSection load='3cla' size='350' side='right' caption='E. coli chloramphenicol acetyltransferase III complex with chloramphenicol and Co+2 ions (PDB entry [[3cla]])' scene='44/449613/Cv/2'>
+
<StructureSection load='3cla' size='350' side='right' caption='E. coli chloramphenicol acetyltransferase III complex with chloramphenicol and Co+2 ions (PDB entry [[3cla]])' scene='44/449613/Cv/9'>
__TOC__
__TOC__
== Function ==
== Function ==
-
[[Chloramphenicol acetyltransferase]] (CAT) is an enzyme which makes bacteria resistant to chloramphenicol. It attaches acetyl from acetyl-CoA to chloramphenicol thus preventing it from binding to the ribosome. Additional details in [[Chloramphenicol Acetyltransferase Type III]].<ref>PMID:2187098</ref>
+
[[Chloramphenicol acetyltransferase]] (CAT) is an enzyme which makes bacteria resistant to chloramphenicol. It attaches acetyl from acetyl-CoA to chloramphenicol thus preventing it from binding to the ribosome. <ref name="Ad">PMID:2187098</ref> Additional details in [[Chloramphenicol Acetyltransferase Type III]].
== Structural highlights ==
== Structural highlights ==
-
In CAT III chloramphenicol binds in a deep pocket at the interface of 2 subunits.
+
<scene name='44/449613/Cv/8'>E. coli chloramphenicol acetyltransferase III is homotrimer</scene>. In <scene name='44/449613/Cv/7'>CAT III chloramphenicol binds in a deep pocket at the interface of 2 subunits</scene> (PDB entry [[3cla]]).<ref name="Ad">PMID:2187098</ref> Water molecules are shown as red spheres.
-
</StructureSection>
+
 
== 3D Structures of Chloramphenicol acetyltransferase ==
== 3D Structures of Chloramphenicol acetyltransferase ==
 +
[[Chloramphenicol acetyltransferase 3D structures]]
-
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+
</StructureSection>
-
{{#tree:id=OrganizedByTopic|openlevels=0|
+
-
 
+
-
*Chloramphenicol acetyltransferase
+
-
 
+
-
**[[3eev]] – CAT – ''Vibrio cholerae''<br />
+
-
**[[2i9d]] – CAT – ''Bacteroides thetaiotamicron''<br />
+
-
 
+
-
*Chloramphenicol acetyltransferase I
+
-
 
+
-
**[[1pd5]], [[1cia]], [[3u9b]] - EcCAT I – ''Escherichia coli''<br />
+
-
**[[1q23]] – EcCAT I + fusidic acid <br />
+
-
**[[1noc]] - EcCAT I + inducible nitric oxide synthase oxygenase domain<br />
+
-
**[[3u9f]] - EcCAT I + chloramphenicol
+
-
 
+
-
*Chloramphenicol acetyltransferase III
+
-
**[[4cla]], [[3cla]], [[1cla]] – EcCAT III + chloramphenicol<br />
 
-
**[[2cla]] - EcCAT III (mutant)<br />
 
-
**[[1qca]] – CAT III (mutant) + fusidic acid – ''Shigella flexneri''<br />
 
-
}}
 
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

E. coli chloramphenicol acetyltransferase III complex with chloramphenicol and Co+2 ions (PDB entry 3cla)

Drag the structure with the mouse to rotate

References

  1. ↑ 1.0 1.1 Leslie AG. Refined crystal structure of type III chloramphenicol acetyltransferase at 1.75 A resolution. J Mol Biol. 1990 May 5;213(1):167-86. PMID:2187098

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

Retrieved from "http://52.214.119.220/wiki/index.php/Chloramphenicol_acetyltransferase"
Personal tools