Chloramphenicol acetyltransferase

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<StructureSection load='3cla' size='350' side='right' caption='E. coli chloramphenicol acetyltransferase III complex with chloramphenicol and Co+2 ions (PDB entry [[3cla]])' scene='44/449613/Cv/3'>
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<StructureSection load='3cla' size='350' side='right' caption='E. coli chloramphenicol acetyltransferase III complex with chloramphenicol and Co+2 ions (PDB entry [[3cla]])' scene='44/449613/Cv/9'>
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== Function ==
== Function ==
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[[Chloramphenicol acetyltransferase]] (CAT) is an enzyme which makes bacteria resistant to chloramphenicol. It attaches acetyl from acetyl-CoA to chloramphenicol thus preventing it from binding to the ribosome. Additional details in [[Chloramphenicol Acetyltransferase Type III]].<ref name="Ad">PMID:2187098</ref>
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[[Chloramphenicol acetyltransferase]] (CAT) is an enzyme which makes bacteria resistant to chloramphenicol. It attaches acetyl from acetyl-CoA to chloramphenicol thus preventing it from binding to the ribosome. <ref name="Ad">PMID:2187098</ref> Additional details in [[Chloramphenicol Acetyltransferase Type III]].
== Structural highlights ==
== Structural highlights ==
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<scene name='44/449613/Cv/4'>E. coli chloramphenicol acetyltransferase III is homotrimer</scene>. In <scene name='44/449613/Cv/7'>CAT III chloramphenicol binds in a deep pocket at the interface of 2 subunits</scene> (PDB entry [[3cla]]).<ref name="Ad">PMID:2187098</ref>
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<scene name='44/449613/Cv/8'>E. coli chloramphenicol acetyltransferase III is homotrimer</scene>. In <scene name='44/449613/Cv/7'>CAT III chloramphenicol binds in a deep pocket at the interface of 2 subunits</scene> (PDB entry [[3cla]]).<ref name="Ad">PMID:2187098</ref> Water molecules are shown as red spheres.
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</StructureSection>
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== 3D Structures of Chloramphenicol acetyltransferase ==
== 3D Structures of Chloramphenicol acetyltransferase ==
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[[Chloramphenicol acetyltransferase 3D structures]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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</StructureSection>
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*Chloramphenicol acetyltransferase
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**[[3eev]] – CAT – ''Vibrio cholerae''<br />
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**[[2i9d]] – CAT – ''Bacteroides thetaiotamicron''<br />
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*Chloramphenicol acetyltransferase I
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**[[1pd5]], [[1cia]], [[3u9b]] - EcCAT I – ''Escherichia coli''<br />
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**[[1q23]] – EcCAT I + fusidic acid <br />
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**[[1noc]] - EcCAT I + inducible nitric oxide synthase oxygenase domain<br />
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**[[3u9f]] - EcCAT I + chloramphenicol
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*Chloramphenicol acetyltransferase III
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**[[4cla]], [[3cla]], [[1cla]] – EcCAT III + chloramphenicol<br />
 
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**[[2cla]] - EcCAT III (mutant)<br />
 
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**[[1qca]] – CAT III (mutant) + fusidic acid – ''Shigella flexneri''<br />
 
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}}
 
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

E. coli chloramphenicol acetyltransferase III complex with chloramphenicol and Co+2 ions (PDB entry 3cla)

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References

  1. ↑ 1.0 1.1 Leslie AG. Refined crystal structure of type III chloramphenicol acetyltransferase at 1.75 A resolution. J Mol Biol. 1990 May 5;213(1):167-86. PMID:2187098

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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