5nvj
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 5nvj is ON HOLD Authors: Twafra, S., Dessau, M. Description: SH3 domain from Mouse cortactin (C 2 2 21 crystal form) [[Category: Unreleased Structu...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==SH3 domain from Mouse cortactin (C 1 2 1 crystal form)== | |
| - | + | <StructureSection load='5nvj' size='340' side='right'caption='[[5nvj]], [[Resolution|resolution]] 1.18Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5nvj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NVJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5NVJ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.18Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BEN:BENZAMIDINE'>BEN</scene>, <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5nvj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nvj OCA], [https://pdbe.org/5nvj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5nvj RCSB], [https://www.ebi.ac.uk/pdbsum/5nvj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5nvj ProSAT]</span></td></tr> |
| - | [[Category: Dessau | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/SRC8_MOUSE SRC8_MOUSE] Contributes to the organization of the actin cytoskeleton and cell structure. In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in the regulation of cell migration. Plays a role in the invasiveness of cancer cells, and the formation of metastases.<ref>PMID:17403031</ref> <ref>PMID:22262902</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Dessau M]] | ||
| + | [[Category: Twafra S]] | ||
Current revision
SH3 domain from Mouse cortactin (C 1 2 1 crystal form)
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