1z7k

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[[Image:1z7k.gif|left|200px]]
 
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{{Structure
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==Crystal Structure of Trypsin- Ovomucoid turkey egg white inhibitor complex==
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|PDB= 1z7k |SIZE=350|CAPTION= <scene name='initialview01'>1z7k</scene>, resolution 1.90&Aring;
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<StructureSection load='1z7k' size='340' side='right'caption='[[1z7k]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>
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<table><tr><td colspan='2'>[[1z7k]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Meleagris_gallopavo Meleagris gallopavo] and [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1r0t 1r0t]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z7K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z7K FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Trypsin Trypsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.4 3.4.21.4] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z7k OCA], [https://pdbe.org/1z7k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z7k RCSB], [https://www.ebi.ac.uk/pdbsum/1z7k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z7k ProSAT]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z7k OCA], [http://www.ebi.ac.uk/pdbsum/1z7k PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1z7k RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/TRYP_PIG TRYP_PIG]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z7/1z7k_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1z7k ConSurf].
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<div style="clear:both"></div>
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'''Crystal Structure of Trypsin- Ovomucoid turkey egg white inhibitor complex'''
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==See Also==
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*[[Trypsin 3D structures|Trypsin 3D structures]]
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__TOC__
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==Overview==
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</StructureSection>
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Crystal structure of the complex between porcine beta-trypsin and the second domain of the Kazal-type ovomucoid turkey egg white trypsin inhibitor (OMTKY2) has been determined at 1.9A resolution. A peptide fragment from the first domain has been crystallized with the complex. Restrained-refinement of the structure led to an R-factor of 0.19 for the 32206 reflections. OMTKY2 exhibits the canonical Kazal-type fold with a central alpha-helix and a short two-stranded anti-parallel beta-sheet. The carbonyl carbon of the reactive site prefers trigonal geometry. The reactive site loop geometry of the inhibitor is complementary to the surface and charge of the binding site in beta-trypsin.
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[[Category: Large Structures]]
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==About this Structure==
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1Z7K is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Meleagris_gallopavo Meleagris gallopavo] and [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. This structure supersedes the now removed PDB entry 1R0T. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z7K OCA].
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==Reference==
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Crystal structure of trypsin-turkey egg white inhibitor complex., Ibrahim BS, Pattabhi V, Biochem Biophys Res Commun. 2004 Jan 2;313(1):8-16. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14672690 14672690]
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[[Category: Meleagris gallopavo]]
[[Category: Meleagris gallopavo]]
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[[Category: Protein complex]]
 
[[Category: Sus scrofa]]
[[Category: Sus scrofa]]
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[[Category: Trypsin]]
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[[Category: Pattabhi V]]
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[[Category: Ibrahim, B Syed.]]
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[[Category: Syed Ibrahim B]]
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[[Category: Pattabhi, V.]]
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[[Category: di-nag]]
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[[Category: hydrolase]]
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[[Category: protease inhibitor]]
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[[Category: serine protease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:31:08 2008''
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Current revision

Crystal Structure of Trypsin- Ovomucoid turkey egg white inhibitor complex

PDB ID 1z7k

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