Collagenase (non-MMP)

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'''Collagenase''' (Col) catalyzes the breaking of peptide bonds in collagen. Col cleaves pro-collagen to create collagen. Some collagenases are part of the [[Matrix metalloproteinase]] family.
'''Collagenase''' (Col) catalyzes the breaking of peptide bonds in collagen. Col cleaves pro-collagen to create collagen. Some collagenases are part of the [[Matrix metalloproteinase]] family.
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*'''Collagenase G''' recognises and unravels collagen microfibrils into triple helices and unwind them<ref>PMID:21947205</ref>.
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*'''Collagenase H''' targets collagen III<ref>PMID:23768818</ref>.
== Relevance ==
== Relevance ==
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__NOTOC__
__NOTOC__
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</StructureSection>
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== 3D Structures of collagenase ==
== 3D Structures of collagenase ==
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[[Collagenase 3D structures]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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</StructureSection>
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*Collagenase G
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**[[2y3u]], [[2y50]] – ChColG residues 119-880 – ''Clostridium histolycum''<br />
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**[[4are]] - ChColG residues 119-790<br />
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**[[2y6i]] - ChColG residues 119-880 + peptide<br />
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**[[4jrw]], [[4tn9]], [[4aqo]], [[2y72]] - ChColG PKD domain<br />
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**[[1nqj]] - ChColG CBD domain <br />
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**[[1nqd]], [[2o8o]], [[4hpk]], [[5iku]] - ChColG CBD domain + Ca<br />
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*Collagenase H
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**[[4u6t]] - ChColH PKD domain<br />
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**[[4jgu]], [[4u7k]] - ChColH PKD domain + Ca<br />
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**[[3jqw]], [[3jqx]] - ChColH CBD domain + Ca<br />
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**[[4ar1]] – ChColH peptidase domain <br />
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**[[4arf]] – CtColH peptidase domain + peptide inhibitor <br />
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*Collagenase T
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**[[4ar9]] – CtColT peptidase domain - ''Clostridium tetani''<br />
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**[[4ar8]] – CtColT peptidase domain + peptide inhibitor <br />
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*Collagenase
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**[[1azz]] – Col + ecotin – fiddler crab<br />
 
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**[[1hyl]], [[2hlc]] – Col – ''Hypoderma lineatum''<br />
 
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**[[5sv5]] – Col C-terminal – ''Bacillus anthracis''<br />
 
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}}
 
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Collagenase H peptidase domain (cyan) complex with peptidic inhibitor, isopentenyl phosphate, Ca+2 (green) and Zn+2 (grey) ions (PDB entry 4arf)

Drag the structure with the mouse to rotate

References

  1. ↑ Eckhard U, Schonauer E, Nuss D, Brandstetter H. Structure of collagenase G reveals a chew-and-digest mechanism of bacterial collagenolysis. Nat Struct Mol Biol. 2011 Sep 25;18(10):1109-14. doi: 10.1038/nsmb.2127. PMID:21947205 doi:10.1038/nsmb.2127
  2. ↑ Fujio A, Murayama K, Yamagata Y, Watanabe K, Imura T, Inagaki A, Ohbayashi N, Shima H, Sekiguchi S, Fujimori K, Igarashi K, Ohuchi N, Satomi S, Goto M. Collagenase H is crucial for isolation of rat pancreatic islets. Cell Transplant. 2014;23(10):1187-98. PMID:23768818 doi:10.3727/096368913X668654
  3. ↑ Eckhard U, Schonauer E, Brandstetter H. Structural basis for activity regulation and substrate preference of clostridial collagenases G, H, and T. J Biol Chem. 2013 May 23. PMID:23703618 doi:10.1074/jbc.M112.448548

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