User:Eric Martz/MHC Quiz

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==Antibody Quiz==
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==MHC Quiz==
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You will get immediate feedback when you click ''Submit'' (at the bottom of the quiz). This quiz is offered to accompany the MHC structure tutorial at [http://molviz.org MolviZ.Org].
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You will get immediate feedback when you click ''Submit'' (at the bottom of the quiz). This quiz is offered to accompany the MHC structure tutorial at [http://molviz.org MolviZ.Org]. All the information needed to answer this quiz correctly is covered in that tutorial.
<!-- (i) = case Insensitive. _7 = width of slot (number of characters) for answer. -->
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- Removes worn out proteins.
- Removes worn out proteins.
- It makes antibody.
- It makes antibody.
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+ It remains bound to the cell membrane.
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- It is released from cells to float freely and bind to CD8.
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{Which kinds of cells express MHC class I?
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|type="[]"}
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+ B lymphocytes.
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+ T lymphocytes.
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- Red blood cells.
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+ Liver cells.
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+ Macrophages.
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+ Dendritic cells.
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{Which kinds of cells express MHC class II?
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|type="[]"}
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- T lymphocytes.
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- Red blood cells.
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- Liver cells.
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+ Macrophages.
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+ Dendritic cells.
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{Why do some viruses impair the expression of MHC class I on their host cells?
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|type="[]"}
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- To hide from Natural Killer Cells.
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+ To hide from CD8 cytotoxic T cells.
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- To attract CD4 helper T cells.
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- To conserve virus peptides.
{What happens to cells that express little or no MHC class I?
{What happens to cells that express little or no MHC class I?
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+ They lose their ability to activate CD8 T lymphocytes.
+ They lose their ability to activate CD8 T lymphocytes.
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{Beta-2 microglobulin
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|type="[]"}
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- Binds to CD8.
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- Has a peptide-binding cleft.
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+ Is part of the MHC class I protein.
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- Is part of the MHC class II protein.
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- Activates T cytotoxic cells.
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- Is an anchor residue.
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{The peptide-binding cleft
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|type="[]"}
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+ Has closed ends in MHC class I.
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- Has closed ends in MHC class II.
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- Has open ends in MHC class I.
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+ Has open ends in MHC class II.
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+ In MHC class I, binds only peptides with specific anchor residues.
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{T lymphocytes examine
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|type="[]"}
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- Peptide amino acid side chains that are buried in the cleft.
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+ Peptide amino acid side chains that are exposed in the cleft.
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+ Both MHC classes I and II.
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- Intact protein antigens.
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{Foreign peptides are distinguished from self peptides by:
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|type="[]"}
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- MHC class I.
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+ CD4 T lymphocytes.
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+ CD8 T lymphocytes.
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- The proteasome.
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- The lysosome.
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{How many polypeptide chains make up an MHC Class I molecule, not counting the antigenic peptide?
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{How many polypeptide chains make up an MHC class I molecule, not counting the antigenic peptide?
|type="{}"}
|type="{}"}
{ 2|two (i)|two. (i) _7 }
{ 2|two (i)|two. (i) _7 }
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||
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{How many polypeptide chains make up the MHC I peptide-binding cleft, not counting the antigenic peptide?
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{How many polypeptide chains make up the MHC class I peptide-binding cleft, not counting the antigenic peptide?
|type="{}"}
|type="{}"}
{ 1|one (i)|one. (i) _7 }
{ 1|one (i)|one. (i) _7 }
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||
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{How many polypeptide chains make up an MHC class II molecule, not counting the antigenic peptide?
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{<hr>'''An IgG1 molecule has a molecular weight of 150 kilo Daltons.'''}
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{
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|type="{}"}
|type="{}"}
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What is the approximate molecular weight of one immunoglobulin domain in kD?
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{ 2|two (i)|two. (i) _7 }
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{ 10-13 _7 } kD.
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||Twelve Ig domains in one IgG1 molecule. 150/12 = 12.5 kD.
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{<hr>
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'''Questions below may have <font color="red">more than one</font> correct answer.'''}
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{Antibody
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|type="[]"}
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+ Binds to antigen.
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+ When bound to a microbe, recruits macrophages and other leukocytes to kill the microbes.
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+ Defends us against infections.
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- Carries oxygen to tissues.
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- Is a hormone.
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- Strengthens bones.
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{How many polypeptide chains make up the MHC class II peptide-binding cleft, not counting the antigenic peptide?
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+
|type="{}"}
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{ 2|two (i)|two. (i) _7 }
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||

Current revision

MHC Quiz

You will get immediate feedback when you click Submit (at the bottom of the quiz). This quiz is offered to accompany the MHC structure tutorial at MolviZ.Org. All the information needed to answer this quiz correctly is covered in that tutorial.


In some cases, more than one answer may be correct.

1. What does "MHC" stand for?

Multiple Histocompatibility Complex.
Manifest Hybridoma Catalyst.
Major Histological Crevice.
Major Histocompatibility Complex.
Minor Histocompatibility Complex.

2. What does MHC class I do?

Presents peptides to CD4 "helper" T lymphocytes.
Presents peptides to CD8 "cytotoxic" T lymphocytes.
Brings peptides from the proteasome to the cell surface.
Brings peptides from the lysosome to the cell surface.
Presents shorter peptides than class II MHC.
Presents longer peptides than class II MHC.
Removes worn out proteins.
It makes antibody.
It remains bound to the cell membrane.
It is released from cells to float freely and bind to CD8.

3. Which kinds of cells express MHC class I?

B lymphocytes.
T lymphocytes.
Red blood cells.
Liver cells.
Macrophages.
Dendritic cells.

4. Which kinds of cells express MHC class II?

T lymphocytes.
Red blood cells.
Liver cells.
Macrophages.
Dendritic cells.

5. Why do some viruses impair the expression of MHC class I on their host cells?

To hide from Natural Killer Cells.
To hide from CD8 cytotoxic T cells.
To attract CD4 helper T cells.
To conserve virus peptides.

6. What happens to cells that express little or no MHC class I?

They are attacked by Natural Killer Cells.
They are attacked by Cytotoxic T Lymphocytes.
Nothing.
They are recycled by the lymphatic system.
They lose their ability to activate CD8 T lymphocytes.

7. Beta-2 microglobulin

Binds to CD8.
Has a peptide-binding cleft.
Is part of the MHC class I protein.
Is part of the MHC class II protein.
Activates T cytotoxic cells.
Is an anchor residue.

8. The peptide-binding cleft

Has closed ends in MHC class I.
Has closed ends in MHC class II.
Has open ends in MHC class I.
Has open ends in MHC class II.
In MHC class I, binds only peptides with specific anchor residues.

9. T lymphocytes examine

Peptide amino acid side chains that are buried in the cleft.
Peptide amino acid side chains that are exposed in the cleft.
Both MHC classes I and II.
Intact protein antigens.

10. Foreign peptides are distinguished from self peptides by:

MHC class I.
CD4 T lymphocytes.
CD8 T lymphocytes.
The proteasome.
The lysosome.

11. How many polypeptide chains make up an MHC class I molecule, not counting the antigenic peptide?

→

12. How many polypeptide chains make up the MHC class I peptide-binding cleft, not counting the antigenic peptide?

→

13. How many polypeptide chains make up an MHC class II molecule, not counting the antigenic peptide?

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14. How many polypeptide chains make up the MHC class II peptide-binding cleft, not counting the antigenic peptide?

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Eric Martz

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