User:Karina Latsko/Sandbox 1
From Proteopedia
< User:Karina Latsko(Difference between revisions)
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==Introduction== | ==Introduction== | ||
| - | + | <StructureSection load='6vz1' size='350' frame='true' side='right' caption='DGAT1 and 6vz1' scene=''> | |
== Structure == | == Structure == | ||
| - | [[Image: | + | [[Image:DGAT_inhibitor.png|200px|right|thumb|Fig 1]] |
| + | |||
| + | <scene name='87/877557/Transmembrane_domain_1/1'>transmembrane domain 1</scene> | ||
| + | This is the reference for our structure <ref name="Sui">PMID:32433611</ref>. | ||
=== Substrates === | === Substrates === | ||
=== Binding Tunnel === | === Binding Tunnel === | ||
=== Catalytic Histidine === | === Catalytic Histidine === | ||
| + | |||
| + | The catalytic residue in DGAT is<scene name='87/877557/Active_site/3'> His415</scene> which is located in the transmembrane region of the L tunnel. | ||
== Disease == | == Disease == | ||
| - | [ | + | [http://en.wikipedia.org/wiki/Disease disease] |
=== Mutations === | === Mutations === | ||
== Relevance == | == Relevance == | ||
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</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
| + | <ref name="Ransey">PMID:28504306</ref>. | ||
| + | <ref name="Sui">PMID:32433611</ref>. | ||
| + | |||
| + | hello <ref name="Ransey">PMID:28504306</ref>. | ||
<references/> | <references/> | ||
Current revision
Contents |
DGAT1: Diglycerol Acyltransferase
Introduction
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References
hello [2].
- ↑ 1.0 1.1 Sui X, Wang K, Gluchowski NL, Elliott SD, Liao M, Walther TC, Farese RV Jr. Structure and catalytic mechanism of a human triacylglycerol-synthesis enzyme. Nature. 2020 May;581(7808):323-328. doi: 10.1038/s41586-020-2289-6. Epub 2020 May, 13. PMID:32433611 doi:http://dx.doi.org/10.1038/s41586-020-2289-6
- ↑ 2.0 2.1 Ransey E, Paredes E, Dey SK, Das SR, Heroux A, Macbeth MR. Crystal structure of the Entamoeba histolytica RNA lariat debranching enzyme EhDbr1 reveals a catalytic Zn(2+) /Mn(2+) heterobinucleation. FEBS Lett. 2017 Jul;591(13):2003-2010. doi: 10.1002/1873-3468.12677. Epub 2017, Jun 14. PMID:28504306 doi:http://dx.doi.org/10.1002/1873-3468.12677
Student Contributors
- Karina Latsko
- Grace Hall
- Megan Leaman
