Beta-N-acetylhexosaminidase

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<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''>
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<StructureSection load='5y0v' size='340' side='right' caption='Glycosylated beta-N-acetylhexosaminidase complex with inhibitor berberine (PDB ID [[5y0v]])' scene='91/917472/Cv/1'>
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== Function ==
== Function ==
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'''Beta-N-acetylhexosaminidase''' or '''Beta-hexosaminidase'''.or '''chitobiase''' (BNAHEX) is a glycoside hydrolase catalysing the cleavage of GlcNAc and GalNAc <ref>PMID:20438826</ref>. BNAHEX serves as a biosynthetic tool for the preparation of hexosaminides under mild conditions.
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'''Beta-N-acetylhexosaminidase''' or '''Beta-hexosaminidase''' or '''chitobiase''' (BNAHEX) is a glycoside hydrolase catalysing the cleavage of GlcNAc and GalNAc <ref>PMID:20438826</ref>. BNAHEX serves as a biosynthetic tool for the preparation of hexosaminides under mild conditions. See also [[Beta-Hexosaminidase]].
== Disease ==
== Disease ==
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Elevated levels of BNAHEX were found in patients wit hay-Sachs disease<ref>PMID:2959149</ref>.
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Elevated levels of BNAHEX were found in patients wit Tay-Sachs disease<ref>PMID:2959149</ref>.
== Relevance ==
== Relevance ==
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BVAHEX is a target for the design of agricultural fungicides<ref>PMID:9535180</ref>.
== Structural highlights ==
== Structural highlights ==
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This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
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The 3D structure of beta-N-acetylhexosaminidase complex with the inhibitor berberine shows the berberine forming <scene name='91/917472/Cv/2'>π-π stacking interaction</scene> interaction with W490. The active site includes a <scene name='91/917472/Cv/3'>hydrophobic recess</scene> interacting with berberine<ref>PMID:30135205</ref>. <scene name='91/917472/Cv/4'>Whole active site</scene>. Water molecules are shown as red spheres.
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==3D structures of beta-N-acetylhexosaminidase ==
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[[Beta-N-acetylhexosaminidase 3D structures]]
</StructureSection>
</StructureSection>
== References ==
== References ==
<references/>
<references/>
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[[Category:Topic Page]]

Current revision

Glycosylated beta-N-acetylhexosaminidase complex with inhibitor berberine (PDB ID 5y0v)

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References

  1. ↑ Slamova K, Bojarova P, Petraskova L, Kren V. beta-N-acetylhexosaminidase: what's in a name...? Biotechnol Adv. 2010 Nov-Dec;28(6):682-93. doi: 10.1016/j.biotechadv.2010.04.004., Epub 2010 May 9. PMID:20438826 doi:http://dx.doi.org/10.1016/j.biotechadv.2010.04.004
  2. ↑ Bayleran J, Hechtman P, Kolodny E, Kaback M. Tay-Sachs disease with hexosaminidase A: characterization of the defective enzyme in two patients. Am J Hum Genet. 1987 Oct;41(4):532-48. PMID:2959149
  3. ↑ Horsch M, Mayer C, Sennhauser U, Rast DM. Beta-N-acetylhexosaminidase: a target for the design of antifungal agents. Pharmacol Ther. 1997 Oct-Dec;76(1-3):187-218. doi: 10.1016/s0163-7258(97)00110-1. PMID:9535180 doi:http://dx.doi.org/10.1016/s0163-7258(97)00110-1
  4. ↑ Duan Y, Liu T, Zhou Y, Dou T, Yang Q. Glycoside hydrolase family 18 and 20 enzymes are novel targets of the traditional medicine berberine. J Biol Chem. 2018 Oct 5;293(40):15429-15438. doi: 10.1074/jbc.RA118.004351. Epub , 2018 Aug 22. PMID:30135205 doi:http://dx.doi.org/10.1074/jbc.RA118.004351

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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