Rho-associated protein kinase
From Proteopedia
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ROCK contains several domains including (in ROCK1) a kinase domain (residues 76-338); a coiled-coil region (residues 339-1103) which contains a Rho-binding domain (residues 934-1015) and a pleckstrin homology and cysteine-rich domain (residues 1103-1320) at the C-terminal. <scene name='75/752224/Cv/4'>ROCK1 inhibitor binds in a pocket</scene> making interactions with a <scene name='75/752224/Cv/5'>glycine-rich loop</scene><ref>PMID:26039570</ref>. | ROCK contains several domains including (in ROCK1) a kinase domain (residues 76-338); a coiled-coil region (residues 339-1103) which contains a Rho-binding domain (residues 934-1015) and a pleckstrin homology and cysteine-rich domain (residues 1103-1320) at the C-terminal. <scene name='75/752224/Cv/4'>ROCK1 inhibitor binds in a pocket</scene> making interactions with a <scene name='75/752224/Cv/5'>glycine-rich loop</scene><ref>PMID:26039570</ref>. | ||
| - | </StructureSection> | ||
==3D structures of Rho-associated protein kinase== | ==3D structures of Rho-associated protein kinase== | ||
| - | + | [[Rho-associated protein kinase 3D structures]] | |
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| - | *Rho-associated protein kinase 1; domains – kinase 6-415; coiled-coil 535-700; Shroom-binding 834-914; Rho-binding 947-1015 | ||
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| - | **[[4l2w]] – hROCK1 Shroom-binding domain - human<br /> | ||
| - | **[[3o0z]] – hROCK1 coiled-coil domain <br /> | ||
| - | **[[5wne]], [[5wnf]], [[5wng]], [[5wnh]], [[6e9w]], [[5hvu]], [[4yvc]], [[4yve]], [[5bml]], [[4w7p]], [[3twj]], [[3tv7]], [[3v8s]], [[3ncz]], [[3ndm]], [[3d9v]], [[2esm]], [[2etk]], [[2etr]], [[5uzj]], [[7jou]] – hROCK1 kinase domain + anti-cancer inhibitor <br /> | ||
| - | **[[5f5p]] – hROCK1 Shroom-binding domain + Shroom2 <br /> | ||
| - | **[[2v55]] – hROCK1 kinase domain + RhoE + GDP + ANP <br /> | ||
| - | **[[1s1c]] – hROCK1 Rho-binding domain + RhoA + GNP<br /> | ||
| - | **[[1uix]] – bROCK1 coiled-coil domain 979-1047 - bovine<br /> | ||
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| - | *Rho-associated protein kinase 2 | ||
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| - | **[[2f2u]] – hROCK2 kinase domain <br /> | ||
| - | **[[4wot]], [[4l6q]], [[2h9v]], [[5u7q]], [[5u7r]], [[6ed6]], [[7jnt]], [[7jov]] – hROCK2 kinase domain + inhibitor <br /> | ||
| - | **[[6p5m]], [[6p5p]] – hROCK2 kinase domain + anti-cancer inhibitor <br /> | ||
| - | **[[2rov]] – hROCK2 split PH domain - NMR<br /> | ||
| - | **[[2row]] – hROCK2 C1 domain - NMR<br /> | ||
| - | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
| + | </StructureSection> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
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