Monoamine oxidase
From Proteopedia
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{{STRUCTURE_2bxr| PDB=2bxr | SIZE=300| SCENE= |right| CAPTION=Human MAO-A complex with FAD and inhibitor clorgyline, [[2bxr]] }} | {{STRUCTURE_2bxr| PDB=2bxr | SIZE=300| SCENE= |right| CAPTION=Human MAO-A complex with FAD and inhibitor clorgyline, [[2bxr]] }} | ||
| - | '''Monoamine oxidas'''e (MAO) are enzymes which catalyze the oxidation of monoamines. MAO contains FAD as co-factor. MAO-A and MAO-C are human enzymes which oxidize adrenaline, noradrenaline, serotonin and dopamine. MAO-B is a human enzyme which oxidizes benzylamine and phenylethylamine. | + | '''Monoamine oxidas'''e (MAO) are enzymes which catalyze the oxidation of monoamines. MAO contains FAD as co-factor. MAO-A and MAO-C are human enzymes which oxidize adrenaline, noradrenaline, serotonin and dopamine. MAO-B is a human enzyme which oxidizes benzylamine and phenylethylamine. For details on MAO-B see [[Monoamine oxidase b]]. |
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Revision as of 10:28, 20 July 2011
Template:STRUCTURE 2bxr
Monoamine oxidase (MAO) are enzymes which catalyze the oxidation of monoamines. MAO contains FAD as co-factor. MAO-A and MAO-C are human enzymes which oxidize adrenaline, noradrenaline, serotonin and dopamine. MAO-B is a human enzyme which oxidizes benzylamine and phenylethylamine. For details on MAO-B see Monoamine oxidase b.
3D structures of monoamine oxidase
MAO-A
2z5x, 2bxr, 2bxs – hMAO-A + inhibitor + FAD – human
2z5y - hMAO-A (mutant) + inhibitor + FAD
1o5w - MAO-A + inhibitor + FAD – rat
MAO-B
1gos – hMAO-B
3po7, 2xcg, 2xfn, 2xfp, 2xfq, 2xfu, 2vz2, 2vrl, 2vrm, 2v5z, 2v60, 2v61, 2c64, 2c65, 2c66, 2c67, 2byb, 2bk3, 1s2q, 1s2y, 1s3b, 1s3e, 1oj9, 1oja, 1ojc, 1ojd – hMAO-B + inhibitor + FAD
2xfo, 2bk4, 2bk5 - hMAO-B (mutant) + inhibitor + FAD
2c72, 2c73, 2c75, 2c76 - hMAO-B (mutant) + FAD
2c70 - hMAO-B + FAD
MAO-C
3qj4 – hMAO-C + FAD
MAO-N
2vvl, 2vvm – MAO-N (mutant) + FAD – Aspergillus niger
