1r0p

(Difference between revisions)

Revision as of 09:20, 11 March 2013

1r0p, resolution 1.80Å ()

Ligands:

Gene:

MET (Homo sapiens)

Activity:

Structural annotation:
Resources:	CATH : 1R0Pa01, 1R0Pa02 InterPro : Ipr001245, Ipr002165, Ipr001627, Ipr000719, Ipr014756, Ipr008266, Ipr011009, Ipr002909, Ipr003659 Pfam : PF07714 SCOP : d1r0pa_ UniProt : P08581

Functional annotation:
Cellular component:	membrane fraction integral to plasma membrane membrane integral to membrane basal plasma membrane
Biological process:	myoblast proliferation muscle development hepatocyte growth factor receptor signaling pathway cell proliferation protein amino acid phosphorylation signal transduction activation of MAPK activity adult behavior brain development multicellular organismal development protein amino acid autophosphorylation cell surface receptor linked signal transduction
Molecular function:	hepatocyte growth factor receptor activity receptor activity nucleotide binding protein-tyrosine kinase activity kinase activity protein kinase activity protein binding transferase activity ATP binding

Evolutionary conservation:

Toggle Conservation Colors:	Rows = identical sequences:
Further Information:	Caveats, Explanation, Complete Results at ConSurfDB

Resources:

FirstGlance, OCA, RCSB, PDBsum

Coordinates:

save as pdb, mmCIF, xml

1r0p is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Schiering N, Knapp S, Marconi M, Flocco MM, Cui J, Perego R, Rusconi L, Cristiani C. Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-Met and its complex with the microbial alkaloid K-252a. Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):12654-9. Epub 2003 Oct 14. PMID:14559966 doi:10.1073/pnas.1734128100

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-[[Image:1r0p.png|left|200px]]
 {{STRUCTURE_1r0p|  PDB=1r0p  |  SCENE=  }}
 ===Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-Met in complex with the microbial alkaloid K-252a===
 {{ABSTRACT_PUBMED_14559966}}