Transthyretin

From Proteopedia

Revision as of 09:35, 22 May 2014

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Transthyretin (TTR) is a serum carrier of the thyroid hormone thyroxine (T4) and retinol through its association with retinol-binding protein (RBP). Many small molecules bind to TTR T4-binding site. TTR is known to be associated with amyloid diseases.

3D structures of transthyretin

Updated on 22-May-2014

2pab, 1tta, 1ttb, 1etb, 1bmz, 1f41, 1dvq, 1fh2, 1qwh, 2h4e, 2qgb, 3cbr, 3d7p, 3cfm, 3i9p, 3a4d, 3a4e, 3a4f, 3u2i, 3w3b, 4mrb – hTTR – human
3u2j – hTTR - neutron
1eta, 1ttc, 1tsh, 2trh, 2try, 1bzd, 1bze, 1fhn, 1g1o, 1x7s, 2qel, 3dgd, 3did, 3kgs, 3tfb – hTTR (amyloidogenic mutant)

1ttr – hTTR (cardiomyapatic mutant)

1bz8, 5ttr, 1f86, 1gko, 1iii, 1iik, 1ijn, 1sok, 1soq, 1x7t, 2g3x, 2g3z, 2g4e, 2g4g, 2noy, 3bt0, 3cxf, 3djr, 3djs, 3djt, 3djz, 3dk0, 3dk2, 3do4, 3gps, 3grb, 3grg, 3i9a, 3i9i, 4mrc – hTTR (mutant)

1tfp – TTR – chicken

2qpf – TTR - mouse

1oo2, 1sn2 – gsTTR – gilthead seabream

1gke – rTTR – rat

TTR binary complexes

1thc, 2h1x, 2h6u – hTTR + hydroxyaurone derivative

1tlm – hTTR + milrinone

1bm7, 3ozl – hTTR + flufenamic acid

1dvs, 1dvt, 1dvu, 1dvx, 1dvy, 1dvz, 1tt6, 1tz8, 2f8i, 2fbr, 2flm, 2g5u, 2g9k, 2gab, 2qgc, 2qgd, 2qge, 3cn0, 3cn1, 3cn2, 3cn3, 3cn4, 3esn, 3eso, 3esp, 3glz, 3gs0, 3gs4, 3gs7, 3imr, 3ims, 3imt, 3imu, 3imv, 3imw, 3ipb, 3ipe, 3m10, 2fbr, 2flm, 3m1o, 3tct, 4fi7, 4fi8, 4fi6 – hTTR + amyloid disease inhibitor
4his, 4hiq - hTTR (mutant) + amyloid disease inhibitor
4abq, 4abv, 4abw, 4ac2, 4ac4, 4act, 4ank, 4abu – hTTR + ligand
4des, 4det, 4der, 4dew, 4deu – hTTR + flavonoid
1u21, 3cfn, 3cfq, 3cft, 3hj0, 3nee, 3neo, 3p3r, 3p3s, 3p3t, 3p3u, 4ky2, 4mas – hTTR + inhibitor

1e3f, 1e4h, 1e5a, 2b15 – hTTR + phenol derivative
4l1s - hTTR + benzamide derivative
4l1t - hTTR + benzoate derivative
4n85, 4n86 - hTTR + glabridin
4n87 - hTTR (mutant) + glabridin
2b14, 2b16 – hTTR (mutant) + phenol derivative

3kgt, 3kgu – hTTR (mutant) + genistein

3ng5 – hTTR (mutant) + epigallocatechin gallate

3nes, 3nex – hTTR (mutant) + inhibitor

1tyr – hTTR + retinoic acid

1kgi – rTTR + tetraiodotyroacetic acid

1z7j - hTTR + tetraiodotyroacetic acid

1kgj – rTTR + dibromoflavone

1zcr, 1zd6 – hTTR + anion
3ssg – hTTR + Zn
1y1d, 2b77, 2b9a, 3d2t, 3fc8, 3fcb, 2f7i, 4ikl, 4ikk, 4ikl, 4iki, 4ik7, 4ik6, 4iiz, 4ikj – hTTR + anti-inflammatory drug
4i89 - hTTR (mutant) + anti-inflammatory drug
4i87, 4i85 - hTTR (mutant) + fibrillogenesis inhibitor
3b56 – hTTR + salicylic acid derivative
4hjs, 4hjt, 4hju – hTTR + covalent kinetic stabilizer

TTR complexes with retinol-binding protein

1rlb, 1qab – hTTR + RBP

2wqa – hTTR + RBP + oleic acid

3bsz – hTTR + RBP + antibody

TTR complexes with thyroxine

2rox, 1ict – hTTR + T4

3ozk – hTTR (mutant) + T4

1tha, 2roy – hTTR + T4 derivative

1ie4 – rTTR + T4

1sn0 – gsTTR + T4

1sn5 – gsTTR + T4 derivative