Thiol peroxidase
From Proteopedia
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{{STRUCTURE_3hvs| PDB=3hvs | SIZE=400| SCENE= |right|CAPTION=E. coli thiol peroxidase dimer complex with citric acid, [[3hvs]] }} | {{STRUCTURE_3hvs| PDB=3hvs | SIZE=400| SCENE= |right|CAPTION=E. coli thiol peroxidase dimer complex with citric acid, [[3hvs]] }} | ||
| - | + | '''Thiol peroxidase''' (TPX) is part of an oxidative stress defense system that uses thioredoxin and thioredoxin reductase to reduce alkyl hydroperoxides. TPX is an antioxidant which reduces peroxides and inhibits hydrogen peroxide response. TPX is also implicated in activation of transcription factors and signaling<ref>PMID:20649470</ref>. | |
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| - | '''Thiol peroxidase''' (TPX) is part of an oxidative stress defense system that uses thioredoxin and thioredoxin reductase to reduce alkyl hydroperoxides. TPX is an antioxidant which reduces peroxides and inhibits hydrogen peroxide response. TPX is also implicated in activation of transcription factors and signaling. | + | |
==3D structures of thiol peroxidase== | ==3D structures of thiol peroxidase== | ||
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[[2yjh]] - YpTPX (mutant)<br /> | [[2yjh]] - YpTPX (mutant)<br /> | ||
[[4gqc]], [[4gqf]] – TPX – ''Aeropyrum pernix''<br /> | [[4gqc]], [[4gqf]] – TPX – ''Aeropyrum pernix''<br /> | ||
| - | + | == References == | |
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[[Category: Topic Page]] | [[Category: Topic Page]] | ||
Revision as of 08:56, 12 September 2016
Thiol peroxidase (TPX) is part of an oxidative stress defense system that uses thioredoxin and thioredoxin reductase to reduce alkyl hydroperoxides. TPX is an antioxidant which reduces peroxides and inhibits hydrogen peroxide response. TPX is also implicated in activation of transcription factors and signaling[1].
3D structures of thiol peroxidase
Updated on 12-September-2016
1q98 – TPX – Haemophilus influenzae
1qxh, 3hvs, 3i43, 4af2 – EcTPX – Escherichia coli
3hvv, 3hvx - EcTPX (mutant)
1xvq – TPX – Mycobacterium tuberculosis
2xpd, 2xpe, 3zrd, 3zre – YpTPX – Yersinia pseudotuberculosis
2yjh - YpTPX (mutant)
4gqc, 4gqf – TPX – Aeropyrum pernix
References
- ↑ Flohe L, Toppo S, Cozza G, Ursini F. A comparison of thiol peroxidase mechanisms. Antioxid Redox Signal. 2011 Aug 1;15(3):763-80. doi: 10.1089/ars.2010.3397. Epub , 2010 Nov 1. PMID:20649470 doi:http://dx.doi.org/10.1089/ars.2010.3397
