Tyrosine phosphatase

====Non-receptor type PTP====

[[1a5y]], [[2hnp]], [[2hnq]], [[1oem]], [[1oeo]], [[1oes]], [[1oet]], [[1oeu]], [[1oev]], [[1sug]], [[2cm2]], [[2cm3]], [[3eu0]], [[3i80]], [[3a5j]], [[1bzc]] - hPTP-b catalytic domain – human<br />

[[1gfy]], [[1i57]], [[1pa1]], [[2f6f]], [[3a5k]], [[3zv2]], [[3qkp]], [[3qkq]] - hPTP-b catalytic domain (mutant) <br />

[[1wch]] – hPTP-e<br />

[[3pdz]] - hPTP-e PDZ2 domain – NMR<BR />

[[1gm1]] - mPTP-BL PDZ2 domain – mouse – NMR<BR />

[[1ozi]] - mPTP-BL PDZ2 domain (mutant) – NMR<BR />

[[3rgo]] – mPTP-1<br />

[[2yz1]] – mPTP SHPS-1 catalytic domain<br />

[[1gwz]], [[2b3o]] – hPTP SHP-1 catalytic domain<br />

[[1x6c]] - hPTP SHP-1 SH2 domain – NMR<BR />

[[2shp]] - hPTP SHP-2 (mutant)<br />

[[2b49]] – hPTPN3 catalytic domain<br />

[[2i75]] – hPTPN4<br />

[[2cs5]] – hPTPN4 PDZ domain – NMR<BR />

[[2vph]] - hPTPN4 PDZ domain<br />

[[2bij]] – hPTPN5 catalytic domain<br />

[[2bv5]] - hPTPN5 catalytic domain (mutant) <br />

[[3ps5]] – hPTPN6 (mutant) <br />

[[4hjp]] – hPTPN6 catalytic domain <br />

[[4gry]], [[4grz]], [[4hjq]] – hPTPN6 catalytic domain (mutant)<br />

[[2dn7]] - hPTPN6 FN3 #6 domain - NMR<br />

[[2dju]], [[2edy]] - hPTPN6 FN3 domain - NMR<br />

[[2a3k]], [[1zc0]] – hPTPN7 catalytic domain<br />

[[2gp0]], [[2hvl]], [[2qdc]], [[2qdm]], [[2qdp]], [[2qds]], [[2qdt]], [[2qdu]], [[3o4s]], [[3o4t]], [[3o4u]] – hPTPN7 catalytic domain (mutant) <br />

[[2pa5]] – hPTPN9 catalytic domain<br />

[[3b7o]], [[3zm0]], [[3zm1]], [[3zm2]], [[3zm3]] - hPTPN11 catalytic domain<br />

[[4dgp]] - hPTPN11 SH2+catalytic domains<br />

[[4dgx]], [[4gwf]], [[4h1o]], [[4h34]] - hPTPN11 SH2+catalytic domains (mutant)<br />

[[3lnx]] – hPTPN13 PDZ2 domain<br />

[[2m0z]] - hPTPN13 PDZ2 domain (mutant) – NMR<br />

[[2bzl]] – hPTPN14 catalytic domain<br />

[[2oc3]] – hPTPN18<br />

[[2p6x]], [[2qcj]], [[3h2x]] – hPTPN22 catalytic domain<br />

[[3rau]] - hPTPN23 His domain

[[1xm2]] – hPTP PRL-1<br />

[[1r6h]], [[1v3a]], [[2mbc]] – hPTP IVA-3 – NMR<BR />

[[1rxd]] - hPTP IVA-1<br />

[[1zck]], [[1x24]] – rPTP 4A1 – rat<br />

[[3i36]] – rPTP-η catalytic domain<br />

[[1c0e]] – bPTP (mutant) – bovine<br />

[[1d1p]], [[2j16]] – yPTP - yeast<br />

[[2j17]] - yPTP (mutant)<br />

[[1g4w]] – StPTP – ''Salmonella typhimurium''<br />

[[2i6i]], [[3ro1]] – SsPTP – ''Sulfolobus solfataricus''<br />

[[2pi7]] – cPTP CRYP-2 catalytic domain <br />

[[2z72]], [[1v73]], [[2zbm]] – PTP residues 22-361 – ''Shewanella''<br />

[[3js5]], [[3jvi]] – EhPTP – ''Entamoeba histolytica''<br />

[[2wjd]], [[2wje]], [[2wjf]] – PTP – ''Streptococcus pneumonia''<br />

[[3qy6]], [[3qy7]], [[3qy8]] – BsPTP – ''Bacillus subtilis''

''Non-receptor type PTP complex with peptide''

[[1ptt]], [[1ptu]], [[1g1f]], [[1g1g]], [[1g1h]], [[1een]], [[1eeo ]] - hPTP-b catalytic domain (mutant) + peptide<br />

[[3i7z]] - hPTP-b catalytic domain + peptide<br />

[[3zmp]], [[3zmq]] – hPTPN1 catalytic domain + peptide<br />

[[1bzh]] - hPTP 1B catalytic domain + fluoromalonyl tyrosine peptide<br />

[[1bzj]] - hPTP 1B catalytic domain + phosphotyrosine mimetic<br />

[[3nfk]], [[3nfl]] - hPTPN4 PDZ domain + peptide<br />

[[2yu7]], [[2rmx]] – hPTPN6 SH2 domain + peptide – NMR<BR />

[[4gs0]] – hPTPN6 catalytic domain + peptide<br />

[[3d42]], [[3d44]] – hPTPN7 catalytic domain (mutant) + peptide<br />

[[4icz]] – hPTPN9 catalytic domain + peptide<br />

[[3tl0]], [[3tkz]] – hPTPN11 SH2 domain + peptide<br />

[[3lny]] - hPTPN13 PDZ2 domain + peptide<br />

[[4gfu]], [[4gfv]] - hPTPN18 residues 6-300 + peptide<br />

[[3brh]], [[3olr]] - hPTPN22 catalytic domain + peptide<br />

[[3omh]] - hPTPN22 catalytic domain (mutant) + peptide<br />

[[3rz2]] - rPTP 4A1 + peptide<br />

[[1fpr]] - hPTP SHP-1 catalytic domain + peptide<br />

[[1aya]], [[1ayb]], [[1ayc]], [[1ayd]] – mPTP Syp N terminal SH2 domain + peptide<br />

[[1vj6]] – mPTP PDZ2 domain + APC C terminal – NMR<br />

[[2dxp]], [[2i6o]] – SsPTP (mutant) + peptide<br />

''Non-receptor type PTP complex with small molecule''

[[1ptv]], [[1pty]] - hPTP-b catalytic domain (mutant) + phosphotyrosine<br />

[[1aax]] - hPTP-b catalytic domain (mutant) + bis-phosphophenyl methane<br />

[[1ecv]], [[1c83]], [[1c84]], [[1c85]], [[1c86]], [[1c87]], [[1c88]], [[1g7f]], [[1g7g]], [[1jf7]], [[1l8g]], [[1kak]], [[1kav]], [[1lqf]], [[1nl9]], [[1nny]], [[1no6]], [[1nz7]], [[1ony]], [[1onz]], [[1ph0]], [[1pxh]], [[1pyn]], [[1q1m]], [[1q6j]], [[1q6m]], [[1q6n]], [[1q6p]], [[1q6s]], [[1q6t]], [[1qxk]], [[1t48]], [[1t49]], [[1t4j]], [[1xbo]], [[1wax]], [[2bgd]], [[2bge]], [[2azr]], [[2b07]], [[2f6t]], [[2f6v]], [[2f6w]], [[2f6y]], [[2f6z]], [[2f70]], [[2f71]], [[2fjn]], [[2cm7]], [[2cm8]], [[2cma]], [[2cmb]], [[2cmc]], [[2h4g]], [[2h4k]], [[2hb1]], [[2cne]], [[2cnf]], [[2cng]], [[2cnh]], [[2cni]], [[2nt7]], [[2nta]], [[2veu]], [[2vev]], [[2vew]], [[2vex]], [[2vey]], [[2qbp]], [[2qbq]], [[2qbr]], [[2qbs]], [[3cwe]], [[3d9c]], [[2zmm]], [[2zn7]], [[3eax]], [[3eb1]], [[3sme]], [[4i8n]] - hPTP-b catalytic domain + inhibitor<br />

[[1nwl]], [[1nwe]], [[2fjm]] - hPTP-b catalytic domain (mutant) + inhibitor<br />

[[4bjo]] – hPTP1 catalytic domain + NO3<br />

[[3rgq]] – mPTP-1 + Pi(5)P<br />

[[2cjz]] - hPTPN5 catalytic domain (mutant) + phosphotyrosine<br />

[[4ge2]], [[4ge5]], [[4ge6]] – hPTP9 catalytic domain + inhibitor<br />

[[3o5x]] – hPTPN11 catalytic domain + inhibitor<br />

[[3mow]] - hPTPN11 catalytic domain + tautomycetin analog<br />

[[2m10]] - hPTPN13 PDZ2 domain (mutant) + azobenzene derivative – NMR<br />

[[2qct]], [[4j51]] – hPTPN22 catalytic domain + inhibitor<br />

[[1zcl]] - rPTP 4A1 (mutant) + sulfate<br />

[[1dg9]] – bPTP + HEPES<br />

[[1d2a]] – yPTP + adenine <br />

[[1d1q]] – yPTP (mutant) + PNPP<br />

[[2i6p]] - SsPTP (mutant) + PNPP<br />

[[2i6j]] – SsPTP + phosphate<br />

[[2i6m]] – SsPTP + WO4<BR />

[[3ido]] – EhPTP + HEPES<br />

''Non-receptor type PTP complex with protein''

[[2b4s]] - hPTP-b catalytic domain + insulin receptor<br />

[[2gph]] - hPTPN7 catalytic domain (mutant) + MAPK2<br />

[[1g4u]] – StPTP + RAS-related C3 botulinum toxin substrate <br />

[[1jyo]] – StPTP + secretion chaperone SICP<br />

[[4je4]], [[4jeg]] – hPTPN11 catalytic domain + monobody<br />

====Yersinia PTP Yop====

[[1yts]], [[2i42]], [[3f99]] - YePTP catalytic domain (mutant) – ''Yersinia enterocolitica''<br />

[[1xxp]], [[1xxv]] - YePTP catalytic domain (mutant) + peptide<br />

[[2i42]] – YePTP (mutant) + VO4<br />

[[1ypt]], [[1ytw]] – YePTP catalytic domain + WO4<BR />

[[1ytn]] - YePTP catalytic domain + NO3<br />

[[1lyv]] - YePTP catalytic domain (mutant) + phosphate<br />

[[3f9a]] – YeYop catalytic domain (mutant) + tungstate<br />

[[3f9b]] – YeYop catalytic domain (mutant) + divanadate<br />

[[1pa9]], [[3bm8]] - YePTP catalytic domain (mutant) + inhibitor<br />

[[3blu]], [[3blt]] - YeYopH catalytic domain + inhibitor<br />

[[3u96]] - YeYopH catalytic domain (mutant) + inhibitor<br />

[[4gf3]] – YeYop residues 21-63 + YeYop targeting protein SYNCH<br />

[[1huf]] – YpYopH N terminal – ''Yersinia pestis''<br />

[[1qz0]] - YpYopH catalytic domain (mutant) + peptide<br />

[[2y2f]] - YpYopH catalytic domain + inhibitor<br />

[[1k46]] - YptYopH N terminal – ''Yersinia pseudotuberculosis''<br />

[[1m0v]] - YptYopH N terminal + phosphopeptide - NMR

====Receptor-type PTP====

[[1yfo]], [[2i1y]] – mRPTP-α catalytic domain<br />

[[1p15]] - mRPTP-α D2 domain<br />

[[3pxh]] - mRPTP Ig domains<br />

[[2nv5]] – RPRP - rat<br />

[[2ahs]] – hRPTP-β<br />

[[2i3r]], [[2i5x]] - hRPTP-β catalytic domain<br />

[[2hc1]], [[2hc2]] - hRPTP-β catalytic domain (mutant) <br />

[[2h4v]], [[2pbn]] – hRPTP-γ domain 1<br />

[[3qcn]] - hRPTP-γ domain 1 (mutant) <br />

[[2nlk]] - hRPTP-γ catalytic domain<br />

[[3jxg]], [[3jxh]] - mRPTP-γ CA-like domain<br />

[[3jxh]] - hRPTP-γ CA-like domain<br />

[[1x5z]] - hRPTP-δ fibronectin type-III domain – NMR<BR />

[[2dlh]] - hRPTP-δ FN3 domain – NMR<BR />

[[2yd6]], [[2yd7]] - hRPTP-δ Ig1-2 domain<br />

[[2jjd]] - hRPTP-ε residues 107-697<br />

[[2c7s]] - hRPTP-κ residues 865-1154<br />

[[1rpm]] - hRPTP-μ catalytic domain<br />

[[2c9a]] - hRPTP-μ MAM-IG module<br />

[[2v5y]] - hRPTP-μ extracellular region<br />

[[2g59]], [[2gjt]] - hRPTP-ο catalytic domain<br />

[[2cfv]] – hRPTP-η residues 1019-1311<br />

[[2nz6]] - hRPTP-η residues 1019-1311 (mutant) <br />

[[2dle]] - hRPTP-η FN3 domain – NMR<BR />

[[2qep]] – hRPTP-ν2 D1 domain<br />

[[4hti]], [[4htj]] – hRPTP-ν2 membrane proximal ectodomain<br />

[[2ooq]] – hRPTP-ρ<br />

[[2fh7]], [[4bpc]] - hRPTP-σ catalytic domain (mutant) <br />

[[2yd9]] - hRPTP-σ Ig1-3 domain (mutant) <br />

[[2yd3]], [[2yd5]] - hRPTP-σ Ig1-2 domain<br />

[[2yd4]] - cRPTP-σ Ig1-2 domain – chicken<br />

[[3jxf]] - hRPTP-ζ CA-like domain<br />

[[2qt7]], [[3n01]], [[3n4w]], [[3ng8]], [[3np5]] – hRPTP IA-2<br />

[[1jln]], [[2a8b]] - mRPTP-R catalytic domain<br />

[[3sr9]] - mRPTP-σ residues 1326 – 1901<br />

[[2edx]] - hRPTP-F fibronectin type-III domain – NMR<BR />

[[2yd1]], [[2yd2]], [[3pxj]] – DmRPTP Ig1-2 domain – ''Drosophila melanogaster''<br />

[[3s3e]] – DmRPTP-10D catalytic domain<br />

''Receptor type PTP complexes''

[[3s3f]] - DmRPTP-10D catalytic domain + VO4<BR />

[[3s3h]] - DmRPTP-10D catalytic domain + peptide<br />

[[3s3k]] - DmRPTP-10D catalytic domain + inhibitor<br />

[[2h02]], [[2h04]], [[2i3u]], [[2i4e]], [[2i4g]], [[2i4h]] - hRPTP-β catalytic domain + inhibitor<br />

[[2h03]] - hRPTP-β catalytic domain (mutant) + inhibitor<br />

[[2hy3]], [[3qcb]], [[3qcc]], [[3qcd]] - hRPTP-γ domain 1 + VO4<BR />

[[3qce]], [[3qcf]], [[3qcg]], [[3qch]], [[3qci]], [[3qcj]], [[3qck]] - hRPTP-γ domain 1 + inhibitor<br />

[[3qcl]], [[3qcm]] - hRPTP-γ domain 1 (mutant) + inhibitor<br />

[[3kld]] - mRPTP-γ CA-like domain + contactin 4<br />

[[2yd8]] - hRPTP-σ Ig1-2 domain + sucrose octasulfate<br />

[[3s97]] - hRPTP-ζ CA-like domain + congtactin Ig domains<br />

[[1ygr]] – hRPTP CD45 cytoplasmic domain (mutant) + T-cell receptor peptide<br />

====Dual-specificity PTP====

[[1t3k]] – DUSP (mutant) – ''Arabidopsis thaliana''<br />

[[2g6z]] – DUSP-5<br />

[[3lj8]] – DUSP-9<br />

[[2wgp]] – hDUSP-14 residues 2-191

===Class II – Low molecular weight PTP===

[[1p8a]] – PTP (mutant) – ''Tritrichomonas foetus'' – NMR<BR />

[[2cwd]] – PTP – ''Thermus thermophilus''<br />

===Class III – CDC25===

[[1l8k]] – hTC-PTP

[[4az1]] – PTP – ''Trypanosoma cruzi''<br />