Gramicidin Channel in Lipid Bilayer
From Proteopedia
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* A detailed explanation and tutorial about [http://biomodel.uah.es/en/model2/bilayer Lipid Bilayers and the Gramicidin Channel]. | * A detailed explanation and tutorial about [http://biomodel.uah.es/en/model2/bilayer Lipid Bilayers and the Gramicidin Channel]. | ||
| - | * [http://firstglance.jmol.org/fg.htm?mol= | + | * [http://firstglance.jmol.org/fg.htm?mol=bilagram.pdb.gz This model in FirstGlance in Jmol]. Be sure to click the ''Ligands+'' and ''Water'' buttons! |
* [http://bme3d.molviz.org/ BioMolecular Explorer 3D], a resource for high school teachers that includes a section on gramicidin in a lipid bilayer. | * [http://bme3d.molviz.org/ BioMolecular Explorer 3D], a resource for high school teachers that includes a section on gramicidin in a lipid bilayer. | ||
* [[High school teachers' resources]] | * [[High school teachers' resources]] | ||
Revision as of 23:29, 29 September 2014
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The scenes on this page have been repaired. Eric Martz 00:37, 30 September 2014 (IST) |
Two copies of the 15-amino-acid gramicidin peptide are shown here () arranged as they are believed to be when they form a channel through a lipid bilayer membrane[1]. The shape of the protein is shown with tiny dots, inside of which is a ribbon backbone trace connecting the alpha carbon atoms of each amino acid chain.
- Show of the gramicidin protein chains. The chains are covalently linked with dioxane in this experiment (C, O),
- (Most hydrogen atoms are omitted.)
C, H, O, N, P. - Show . Notice how the hydrophobic lipid "tails" exclude water.
- Water passes .
-
Show .
-
Show only .
C, H, O, N, P.
For an explanation of their structure, see the detailed tutorial, also disponible en español.
| Remember to use the popup button and then resize the popup window to enlarge the molecular scenes. |
See Also
- A detailed explanation and tutorial about Lipid Bilayers and the Gramicidin Channel.
- This model in FirstGlance in Jmol. Be sure to click the Ligands+ and Water buttons!
- BioMolecular Explorer 3D, a resource for high school teachers that includes a section on gramicidin in a lipid bilayer.
- High school teachers' resources
- The Spanish version of this page: Canal de gramicidina en bicapa lipídica (Spanish)
- For additional information, see: Membrane Channels & Pumps
Notes
- The PDB file shown here, Image:Gramicidin in bilayer.pdb.gz, was kindly provided by Serge Crouzy[1].
- To load the scenes on this page into the SAT, change the page name to User:Eric_Martz/Sandbox_10, where these scenes were developed.
References
- ↑ 1.0 1.1 1.2 Crouzy S, Woolf TB, Roux B. A molecular dynamics study of gating in dioxolane-linked gramicidin A channels. Biophys J. 1994 Oct;67(4):1370-86. PMID:7529578 doi:http://dx.doi.org/10.1016/S0006-3495(94)80618-6
