Tyrosine phosphatase

{{STRUCTURE_3i7z| PDB=3i7z | SIZE=400| SCENE= |right|CAPTION=Human tyrosine phosphatase 1B catalytic domain (grey) complex with EGFR peptide (in green), VO4, glycerol, Tris, 2-amino-2-hydroxymethyl-1,3-diol, [[3i7z]] }}

{{STRUCTURE_3i7z| PDB=3i7z | SIZE=400| SCENE= |right|CAPTION=Human tyrosine phosphatase 1B catalytic domain (grey) complex with EGFR peptide (in green), VO4, glycerol, Tris, 2-amino-2-hydroxymethyl-1,3-diol, [[3i7z]] }}

'''Tyrosine phosphatase''' (PTP) is an enzyme which removes phosphate from phosphorylated tyrosine residues. It is a key regulatory component of signal transduction pathways. PTPs are divided to 4 subfamilies. PTP class I contains receptor PTPs (RPTP) and dual-specificity PTP which removes phosphate from Ser/Thr and tyrosine. PTP class III contains CDC25 which removes phosphate from Thr and tyrosine. PTP containing SH2 domains are called PTP SHP.<br />For details on ''Yersinia'' PTP see [[Yersinia YopH]].<br />For details of PTP complex with inhibitor see [[Student Projects for UMass Chemistry 423 Spring 2012-9]].

'''Tyrosine phosphatase''' (PTP) is an enzyme which removes phosphate from phosphorylated tyrosine residues. It is a key regulatory component of signal transduction pathways. PTPs are divided to 4 subfamilies. PTP class I contains receptor PTPs (RPTP) and dual-specificity PTP which removes phosphate from Ser/Thr and tyrosine. PTP class III contains CDC25 which removes phosphate from Thr and tyrosine. PTP containing SH2 domains are called PTP SHP.<br />For details on ''Yersinia'' PTP see [[Yersinia YopH]].<br />For details of PTP complex with inhibitor see [[Student Projects for UMass Chemistry 423 Spring 2012-9]].

== 3D Structures of tyrosine phosphatase ==

== 3D Structures of tyrosine phosphatase ==

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[[Category:Topic Page]]