Thioredoxin Glutathione Reductase

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== Relevance ==
== Relevance ==
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TGR is a therpeutic drug target against schistosomiasis<ref>PMID:22384025</ref>.
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TGR is a therpeutic drug target against the parasitic disease schistosomiasis<ref>PMID:22384025</ref>.
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== Structural highlights ==
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The active site of TGR contains CXXC and CXXXXC motifs and FAD<ref>PMID:20659890</ref>.
== 3D Structures of Thioredoxin Glutathione Reductase ==
== 3D Structures of Thioredoxin Glutathione Reductase ==

Revision as of 10:01, 13 September 2016

Image:2v6o.png
Crystal Structure of Thioredoxin Glutathione Reductase (2v6o)

Template:STRUCTURE 2x8c










Contents

Function

Thioredoxin Glutathione Reductase (TGR) is an enzyme which bridges two detoxification pathways[1]. It is composed of a small glutaredoxin domain at the N-terminal and a large thioredoxin reductase one at the C-terminal.

Relevance

TGR is a therpeutic drug target against the parasitic disease schistosomiasis[2].

Structural highlights

The active site of TGR contains CXXC and CXXXXC motifs and FAD[3].

3D Structures of Thioredoxin Glutathione Reductase

2v6o, 2x8c, 2x8g, 2x8h – SmTGR+FAD – Schistosoma mansoni
2x99 - SmTGR+FAD+NADPH
3h4k - SmTGR+FAD+auranofin
4la1 - TGR+FAD – Schistosoma japonicum

References

  1. ↑ Prast-Nielsen S, Huang HH, Williams DL. Thioredoxin glutathione reductase: its role in redox biology and potential as a target for drugs against neglected diseases. Biochim Biophys Acta. 2011 Dec;1810(12):1262-71. doi:, 10.1016/j.bbagen.2011.06.024. Epub 2011 Jul 14. PMID:21782895 doi:http://dx.doi.org/10.1016/j.bbagen.2011.06.024
  2. ↑ Song L, Li J, Xie S, Qian C, Wang J, Zhang W, Yin X, Hua Z, Yu C. Thioredoxin glutathione reductase as a novel drug target: evidence from Schistosoma japonicum. PLoS One. 2012;7(2):e31456. doi: 10.1371/journal.pone.0031456. Epub 2012 Feb 22. PMID:22384025 doi:http://dx.doi.org/10.1371/journal.pone.0031456
  3. ↑ Angelucci F, Dimastrogiovanni D, Boumis G, Brunori M, Miele AE, Saccoccia F, Bellelli A. Mapping the catalytic cycle of Schistosoma mansoni thioredoxin glutathione reductase by x-ray crystallography. J Biol Chem. 2010 Jul 21. PMID:20659890 doi:10.1074/jbc.M110.141960

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Marcin Jozef Suskiewicz

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