Tyrosine phosphatase
From Proteopedia
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<StructureSection load='3i7z' size='340' side='right' caption='Human tyrosine phosphatase 1B catalytic domain (grey) complex with EGFR peptide (in green), VO4, glycerol, Tris, 2-amino-2-hydroxymethyl-1,3-diol, [[3i7z]]' scene='' > | <StructureSection load='3i7z' size='340' side='right' caption='Human tyrosine phosphatase 1B catalytic domain (grey) complex with EGFR peptide (in green), VO4, glycerol, Tris, 2-amino-2-hydroxymethyl-1,3-diol, [[3i7z]]' scene='' > | ||
| - | '''Tyrosine phosphatase''' (PTP) is an enzyme which removes phosphate from phosphorylated tyrosine residues. It is a key regulatory component of signal transduction pathways. PTPs are divided to 4 subfamilies. PTP class I contains receptor PTPs (RPTP) and dual-specificity PTP which removes phosphate from Ser/Thr and tyrosine. PTP class III contains CDC25 which removes phosphate from Thr and tyrosine. PTP containing SH2 domains are called PTP SHP.<br />For details on ''Yersinia'' PTP see [[Yersinia YopH]].<br />For details of PTP complex with inhibitor see [[Student Projects for UMass Chemistry 423 Spring 2012-9]]. | + | '''Tyrosine phosphatase''' (PTP) is an enzyme which removes phosphate from phosphorylated tyrosine residues. It is a key regulatory component of signal transduction pathways<ref>PMID:14625689</ref>. PTPs are divided to 4 subfamilies. '''PTP class I''' contains receptor PTPs (RPTP) and dual-specificity PTP which removes phosphate from Ser/Thr and tyrosine. '''PTP class III''' contains CDC25 which removes phosphate from Thr and tyrosine. PTP containing SH2 domains are called PTP SHP.<br />For details on ''Yersinia'' PTP see [[Yersinia YopH]].<br />For details of PTP complex with inhibitor see [[Student Projects for UMass Chemistry 423 Spring 2012-9]]. |
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| + | == Disease == | ||
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| + | PTP mutations are involved in cancers<ref>PMID:16557282</ref>. | ||
</StructureSection> | </StructureSection> | ||
== 3D Structures of tyrosine phosphatase == | == 3D Structures of tyrosine phosphatase == | ||
Revision as of 10:18, 28 November 2016
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3D Structures of tyrosine phosphatase
Updated on 28-November-2016
References
- ↑ Paul S, Lombroso PJ. Receptor and nonreceptor protein tyrosine phosphatases in the nervous system. Cell Mol Life Sci. 2003 Nov;60(11):2465-82. PMID:14625689 doi:http://dx.doi.org/10.1007/s00018-003-3123-7
- ↑ Ostman A, Hellberg C, Bohmer FD. Protein-tyrosine phosphatases and cancer. Nat Rev Cancer. 2006 Apr;6(4):307-20. PMID:16557282 doi:http://dx.doi.org/10.1038/nrc1837
