Tyrosine phosphatase

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Line 45: Line 45:
**[[4dgp]] - hPTPN11 SH2+catalytic domains<br />
**[[4dgp]] - hPTPN11 SH2+catalytic domains<br />
**[[4dgx]], [[4gwf]], [[4h1o]], [[4h34]], [[4nwf]], [[4nwg]], [[4ohd]], [[4ohe]], [[4ohh]], [[4ohi]] - hPTPN11 SH2+catalytic domains (mutant)<br />
**[[4dgx]], [[4gwf]], [[4h1o]], [[4h34]], [[4nwf]], [[4nwg]], [[4ohd]], [[4ohe]], [[4ohh]], [[4ohi]] - hPTPN11 SH2+catalytic domains (mutant)<br />
 +
**[[5j8r]], [[5i6v]], [[5ibm]], [[5ibs]] - hPTPN11 catalytic domain (mutant)<br />
 +
**[[5glj]] - hPTPN13 PDZ1 domain <br />
**[[3lnx]] – hPTPN13 PDZ2 domain<br />
**[[3lnx]] – hPTPN13 PDZ2 domain<br />
**[[2m0z]] - hPTPN13 PDZ2 domain (mutant) – NMR<br />
**[[2m0z]] - hPTPN13 PDZ2 domain (mutant) – NMR<br />
Line 50: Line 52:
**[[2oc3]] – hPTPN18<br />
**[[2oc3]] – hPTPN18<br />
**[[2p6x]], [[2qcj]], [[3h2x]] – hPTPN22 catalytic domain<br />
**[[2p6x]], [[2qcj]], [[3h2x]] – hPTPN22 catalytic domain<br />
-
**[[3rau]] - hPTPN23 His domain
+
**[[3rau]] - hPTPN23 His domain<br />
 +
**[[5cru]] – hRPTP23 domain Bro<br />
**[[1xm2]] – hPTP PRL-1<br />
**[[1xm2]] – hPTP PRL-1<br />
**[[1r6h]], [[1v3a]], [[2mbc]] – hPTP IVA-3 – NMR<BR />
**[[1r6h]], [[1v3a]], [[2mbc]] – hPTP IVA-3 – NMR<BR />
Line 75: Line 78:
**[[1bzh]] - hPTP 1B catalytic domain + fluoromalonyl tyrosine peptide<br />
**[[1bzh]] - hPTP 1B catalytic domain + fluoromalonyl tyrosine peptide<br />
**[[1bzj]] - hPTP 1B catalytic domain + phosphotyrosine mimetic<br />
**[[1bzj]] - hPTP 1B catalytic domain + phosphotyrosine mimetic<br />
-
**[[3nfk]], [[3nfl]] - hPTPN4 PDZ domain + peptide<br />
+
**[[3nfk]], [[3nfl]], [[5eyz]], [[5ez0]] - hPTPN4 PDZ domain + peptide<br />
**[[2yu7]], [[2rmx]] – hPTPN6 SH2 domain + peptide – NMR<BR />
**[[2yu7]], [[2rmx]] – hPTPN6 SH2 domain + peptide – NMR<BR />
**[[4gs0]] – hPTPN6 catalytic domain + peptide<br />
**[[4gs0]] – hPTPN6 catalytic domain + peptide<br />
**[[3d42]], [[3d44]] – hPTPN7 catalytic domain (mutant) + peptide<br />
**[[3d42]], [[3d44]] – hPTPN7 catalytic domain (mutant) + peptide<br />
**[[4icz]] – hPTPN9 catalytic domain + peptide<br />
**[[4icz]] – hPTPN9 catalytic domain + peptide<br />
-
**[[3tl0]], [[3tkz]] – hPTPN11 SH2 domain + peptide<br />
+
**[[3tl0]], [[3tkz]],[[5df6]], [[4qsy]] – hPTPN11 SH2 domain + peptide<br />
**[[3lny]] - hPTPN13 PDZ2 domain + peptide<br />
**[[3lny]] - hPTPN13 PDZ2 domain + peptide<br />
**[[4gfu]], [[4gfv]] - hPTPN18 residues 6-300 + peptide<br />
**[[4gfu]], [[4gfv]] - hPTPN18 residues 6-300 + peptide<br />
Line 86: Line 89:
**[[3brh]], [[3olr]] - hPTPN22 catalytic domain + peptide<br />
**[[3brh]], [[3olr]] - hPTPN22 catalytic domain + peptide<br />
**[[3omh]] - hPTPN22 catalytic domain (mutant) + peptide<br />
**[[3omh]] - hPTPN22 catalytic domain (mutant) + peptide<br />
 +
**[[5crv]] – hRPTP23 domain Bro + STAM2 peptide<br />
**[[3rz2]] - rPTP 4A1 + peptide<br />
**[[3rz2]] - rPTP 4A1 + peptide<br />
**[[1fpr]] - hPTP SHP-1 catalytic domain + peptide<br />
**[[1fpr]] - hPTP SHP-1 catalytic domain + peptide<br />
Line 96: Line 100:
**[[1ptv]], [[1pty]] - hPTP-b catalytic domain (mutant) + phosphotyrosine<br />
**[[1ptv]], [[1pty]] - hPTP-b catalytic domain (mutant) + phosphotyrosine<br />
**[[1aax]] - hPTP-b catalytic domain (mutant) + bis-phosphophenyl methane<br />
**[[1aax]] - hPTP-b catalytic domain (mutant) + bis-phosphophenyl methane<br />
-
**[[1ecv]], [[1c83]], [[1c84]], [[1c85]], [[1c86]], [[1c87]], [[1c88]], [[1g7f]], [[1g7g]], [[1jf7]], [[1l8g]], [[1kak]], [[1kav]], [[1lqf]], [[1nl9]], [[1nny]], [[1no6]], [[1nz7]], [[1ony]], [[1onz]], [[1ph0]], [[1pxh]], [[1pyn]], [[1q1m]], [[1q6j]], [[1q6m]], [[1q6n]], [[1q6p]], [[1q6s]], [[1q6t]], [[1qxk]], [[1t48]], [[1t49]], [[1t4j]], [[1xbo]], [[1wax]], [[2bgd]], [[2bge]], [[2azr]], [[2b07]], [[2f6t]], [[2f6v]], [[2f6w]], [[2f6y]], [[2f6z]], [[2f70]], [[2f71]], [[2fjn]], [[2cm7]], [[2cm8]], [[2cma]], [[2cmb]], [[2cmc]], [[2h4g]], [[2h4k]], [[2hb1]], [[2cne]], [[2cnf]], [[2cng]], [[2cnh]], [[2cni]], [[2nt7]], [[2nta]], [[2veu]], [[2vev]], [[2vew]], [[2vex]], [[2vey]], [[2qbp]], [[2qbq]], [[2qbr]], [[2qbs]], [[3cwe]], [[3d9c]], [[2zmm]], [[2zn7]], [[3eax]], [[3eb1]], [[3sme]], [[4i8n]] - hPTP-b catalytic domain + inhibitor<br />
+
**[[1ecv]], [[1c83]], [[1c84]], [[1c85]], [[1c86]], [[1c87]], [[1c88]], [[1g7f]], [[1g7g]], [[1jf7]], [[1l8g]], [[1kak]], [[1kav]], [[1lqf]], [[1nl9]], [[1nny]], [[1no6]], [[1nz7]], [[1ony]], [[1onz]], [[1ph0]], [[1pxh]], [[1pyn]], [[1q1m]], [[1q6j]], [[1q6m]], [[1q6n]], [[1q6p]], [[1q6s]], [[1q6t]], [[1qxk]], [[1t48]], [[1t49]], [[1t4j]], [[1xbo]], [[1wax]], [[2bgd]], [[2bge]], [[2azr]], [[2b07]], [[2f6t]], [[2f6v]], [[2f6w]], [[2f6y]], [[2f6z]], [[2f70]], [[2f71]], [[2fjn]], [[2cm7]], [[2cm8]], [[2cma]], [[2cmb]], [[2cmc]], [[2h4g]], [[2h4k]], [[2hb1]], [[2cne]], [[2cnf]], [[2cng]], [[2cnh]], [[2cni]], [[2nt7]], [[2nta]], [[2veu]], [[2vev]], [[2vew]], [[2vex]], [[2vey]], [[2qbp]], [[2qbq]], [[2qbr]], [[2qbs]], [[3cwe]], [[3d9c]], [[2zmm]], [[2zn7]], [[3eax]], [[3eb1]], [[3sme]], [[4i8n]], [[4y14]] - hPTP-b catalytic domain + inhibitor<br />
**[[1nwl]], [[1nwe]], [[2fjm]] - hPTP-b catalytic domain (mutant) + inhibitor<br />
**[[1nwl]], [[1nwe]], [[2fjm]] - hPTP-b catalytic domain (mutant) + inhibitor<br />
**[[4bjo]] – hPTP1 catalytic domain + NO3<br />
**[[4bjo]] – hPTP1 catalytic domain + NO3<br />
Line 103: Line 107:
**[[2cjz]] - hPTPN5 catalytic domain (mutant) + phosphotyrosine<br />
**[[2cjz]] - hPTPN5 catalytic domain (mutant) + phosphotyrosine<br />
**[[4ge2]], [[4ge5]], [[4ge6]] – hPTP9 catalytic domain + inhibitor<br />
**[[4ge2]], [[4ge5]], [[4ge6]] – hPTP9 catalytic domain + inhibitor<br />
-
**[[3o5x]], [[4pvg]] – hPTPN11 catalytic domain + inhibitor<br />
+
**[[3o5x]], [[4pvg]], [[5ehp]], [[5ehr]], [[4rdd]] – hPTPN11 catalytic domain + inhibitor<br />
**[[3mow]] - hPTPN11 catalytic domain + tautomycetin analog<br />
**[[3mow]] - hPTPN11 catalytic domain + tautomycetin analog<br />
**[[2m10]] - hPTPN13 PDZ2 domain (mutant) + azobenzene derivative – NMR<br />
**[[2m10]] - hPTPN13 PDZ2 domain (mutant) + azobenzene derivative – NMR<br />
Line 127: Line 131:
*'''Yersinia tyrosine phosphatase Yop'''
*'''Yersinia tyrosine phosphatase Yop'''
-
**[[1yts]], [[2i42]], [[3f99]] - YePTP catalytic domain (mutant) – ''Yersinia enterocolitica''<br />
+
**[[1yts]], [[4yaa]], [[4z6b]], [[4zi4]], [[4zn5]] - YePTP catalytic domain (mutant) – ''Yersinia enterocolitica''<br />
**[[1xxp]], [[1xxv]] - YePTP catalytic domain (mutant) + peptide<br />
**[[1xxp]], [[1xxv]] - YePTP catalytic domain (mutant) + peptide<br />
**[[2i42]] – YePTP (mutant) + VO4<br />
**[[2i42]] – YePTP (mutant) + VO4<br />
-
**[[1ypt]], [[1ytw]] – YePTP catalytic domain + WO4<BR />
+
**[[1ypt]], [[1ytw]] – YePTP catalytic domain + WO4<br />
**[[1ytn]] - YePTP catalytic domain + NO3<br />
**[[1ytn]] - YePTP catalytic domain + NO3<br />
**[[1lyv]] - YePTP catalytic domain (mutant) + phosphate<br />
**[[1lyv]] - YePTP catalytic domain (mutant) + phosphate<br />
-
**[[3f9a]] – YeYop catalytic domain (mutant) + tungstate<br />
 
-
**[[3f9b]] – YeYop catalytic domain (mutant) + divanadate<br />
 
**[[1pa9]], [[3bm8]] - YePTP catalytic domain (mutant) + inhibitor<br />
**[[1pa9]], [[3bm8]] - YePTP catalytic domain (mutant) + inhibitor<br />
-
**[[3blu]], [[3blt]] - YeYopH catalytic domain + inhibitor<br />
+
**[[3u96]] - YePTP catalytic domain (mutant) + PNCS<br />
-
**[[3u96]] - YeYopH catalytic domain (mutant) + inhibitor<br />
+
**[[1huf]] – YpPTP - ''Yersinia pestis''<br />
-
**[[4gf3]] – YeYop residues 21-63 + YeYop targeting protein SYNCH<br />
+
**[[1qz0]] - YpPTP catalytic domain + peptide<br />
-
**[[1huf]] – YpYopH N terminal – ''Yersinia pestis''<br />
+
**[[2y2f]] - YpPTP catalytic domain + inhibitor<br />
-
**[[1qz0]] - YpYopH catalytic domain (mutant) + peptide<br />
+
**[[1k46]] - YpPTP N terminal domain<br />
-
**[[2y2f]] - YpYopH catalytic domain + inhibitor<br />
+
**[[1m0v]] - YpPTP N terminal domain + peptide – NMR<br />
-
**[[1k46]] - YptYopH N terminal – ''Yersinia pseudotuberculosis''<br />
+
**[[4gf3]] – YpPTP + Yop targeting protein<br />
-
**[[1m0v]] - YptYopH N terminal + phosphopeptide - NMR
+
*'''Receptor-type tyrosine phosphatase'''
*'''Receptor-type tyrosine phosphatase'''
Line 167: Line 168:
**[[3jxg]], [[3jxh]] - mRPTP-γ CA-like domain<br />
**[[3jxg]], [[3jxh]] - mRPTP-γ CA-like domain<br />
**[[3jxh]] - hRPTP-γ CA-like domain<br />
**[[3jxh]] - hRPTP-γ CA-like domain<br />
 +
**[[5fmv]] - hRPTP-γ domain D1-D4<br />
 +
**[[5fn6]] - hRPTP-γ domain D1-D3<br />
 +
**[[5fn7]] - hRPTP-γ domain D1-D2<br />
 +
**[[5fn8]] - rRPTP-γ domain D3-D4<br />
**[[1x5z]] - hRPTP-δ fibronectin type-III domain – NMR<BR />
**[[1x5z]] - hRPTP-δ fibronectin type-III domain – NMR<BR />
**[[4yfe]] - hRPTP-δ FN1-FN2 domain<br />
**[[4yfe]] - hRPTP-δ FN1-FN2 domain<br />
Line 189: Line 194:
**[[4pbx]] - hRPTP-σ residues 30-588<br />
**[[4pbx]] - hRPTP-σ residues 30-588<br />
**[[3jxf]] - hRPTP-ζ CA-like domain<br />
**[[3jxf]] - hRPTP-ζ CA-like domain<br />
 +
**[[5awx]] - hRPTP-ζ D1 domain<br />
**[[2qt7]], [[3n01]], [[3n4w]], [[3ng8]], [[3np5]] – hRPTP IA-2<br />
**[[2qt7]], [[3n01]], [[3n4w]], [[3ng8]], [[3np5]] – hRPTP IA-2<br />
**[[4n5u]] - hRPTP-F fibronectin type-III domain<br />
**[[4n5u]] - hRPTP-F fibronectin type-III domain<br />
Line 203: Line 209:
**[[3qce]], [[3qcf]], [[3qcg]], [[3qch]], [[3qci]], [[3qcj]], [[3qck]] - hRPTP-γ domain 1 + inhibitor<br />
**[[3qce]], [[3qcf]], [[3qcg]], [[3qch]], [[3qci]], [[3qcj]], [[3qck]] - hRPTP-γ domain 1 + inhibitor<br />
**[[3qcl]], [[3qcm]] - hRPTP-γ domain 1 (mutant) + inhibitor<br />
**[[3qcl]], [[3qcm]] - hRPTP-γ domain 1 (mutant) + inhibitor<br />
 +
**[[5e5r]] - hRPTP-γ domain CA + contactin 3<br />
 +
**[[5e5u]] - mRPTP-γ domain CA + contactin 6<br />
**[[3kld]] - mRPTP-γ CA-like domain + contactin 4<br />
**[[3kld]] - mRPTP-γ CA-like domain + contactin 4<br />
**[[4rca]], [[4y61]] - hRPTP-δ + SLITRK1<br />
**[[4rca]], [[4y61]] - hRPTP-δ + SLITRK1<br />
Line 214: Line 222:
**[[1t3k]] – DUSP (mutant) – ''Arabidopsis thaliana''<br />
**[[1t3k]] – DUSP (mutant) – ''Arabidopsis thaliana''<br />
**[[2g6z]] – hDUSP-5<br />
**[[2g6z]] – hDUSP-5<br />
 +
**[[4y2e]] – hDUSP-7 (mutant)<br />
**[[3lj8]] – hDUSP-9<br />
**[[3lj8]] – hDUSP-9<br />
**[[4jnb]], [[4ki9]] – hDUSP-12 catalytic domain (mutant)<br />
**[[4jnb]], [[4ki9]] – hDUSP-12 catalytic domain (mutant)<br />
-
**[[2wgp]] – hDUSP-14 residues 2-191
+
**[[2wgp]] – hDUSP-14 residues 2-191<br />
 +
**[[4yr8]] – hDUSP-16 + MAPK8<br />
 +
**[[4d3p]], [[4d3q]], [[4d3r]] – hDUSP-19 (mutant)<br />
 +
**[[4woh]] – hDUSP-22 (mutant) + nitrophenolphosphate<br />
 +
**[[5gtj]] – hDUSP-26<br />
*'''Class II'''
*'''Class II'''
-
*'''Low molecular weight tyrosine phosphatase'''
+
*'''Low molecular weight tyrosine phosphatase (LMW-PTP)'''
-
**[[1p8a]] – PTP (mutant) – ''Tritrichomonas foetus'' – NMR<BR />
+
**[[1p8a]] – LMW-PTP (mutant) – ''Tritrichomonas foetus'' – NMR<BR />
-
**[[2cwd]] – PTP – ''Thermus thermophilus''<br />
+
**[[2cwd]] – LMW-PTP – ''Thermus thermophilus''<br />
-
**[[1phr]] - bPTP<br />
+
**[[5got]] – LMW-PTP – ''Streptococcus pyogenes''<br />
-
**[[1xww]] - hPTP <br />
+
**[[1phr]] - bLMW-PTP<br />
-
**[[1z12]] - bPTP + VO4<br />
+
**[[1xww]], [[4z99]] - hLMW-PTP <br />
 +
**[[1u2p]], [[2luo]] – MtLMW-PTP – ''Mycobacterium tuberculosis''<br />
 +
**[[2oz5]] – MtLMW-PTP + inhibitor<br />
 +
**[[2fek]] – LMW-PTP – ''Escherichia coli''<br />
 +
**[[4eti]], [[4etm]], [[4kk3]] – BsLMW-PTP<br />
 +
**[[4etn]], [[4kk4]] – BsLMW-PTP (mutant)<br />
 +
 
 +
*LMW-PTP complex
 +
 
 +
**[[5kqg]], [[5kql]], [[5kqm]], [[5kqp]] – hLMW-PTP + inhibitor<br />
 +
**[[4z9a]] – hLMW-PTP + phenylmethanesulfonic acid<br />
 +
**[[4z9b]] – hLMW-PTP + benzylphosphonic acid<br />
 +
**[[1z12]] - bLMW-PTP + VO4<br />
**[[1z13]] - bPTP + MoO4<br />
**[[1z13]] - bPTP + MoO4<br />
-
**[[3rof]] – PTP-A + peptide – ''Staphylococcus aureus''<br />
+
**[[3rof]] – LMW-PTP-A + peptide – ''Staphylococcus aureus''<br />
-
**[[1u2p]], [[2luo]] – MtPTP – ''Mycobacterium tuberculosis''<br />
+
**[[1u2q]] – MtLMW-PTP + glycerol<br />
-
**[[1u2q]] – MtPTP + glycerol<br />
+
**[[2oz5]] – MtLMW-PTP + inhibitor<br />
-
**[[2oz5]] – MtPTP + inhibitor<br />
+
-
**[[2fek]] – PTP – ''Escherichia coli''<br />
+
-
**[[4eti]], [[4etm]], [[4kk3]] – BsPTP<br />
+
-
**[[4etn]], [[4kk4]] – BsPTP (mutant)<br />
+
-
*'''Class III'''
+
*'''Class III or M-phase inducer phosphatase 2'''
*'''CDC25'''
*'''CDC25'''
Line 243: Line 264:
**[[1qb0]], [[1cwr]], [[1ym9]], [[1ymd]], [[1ymk]], [[1yml]], [[1ys0]], [[2uzq]] - hCDC25B catalytic domain<br />
**[[1qb0]], [[1cwr]], [[1ym9]], [[1ymd]], [[1ymk]], [[1yml]], [[1ys0]], [[2uzq]] - hCDC25B catalytic domain<br />
**[[2a2k]], [[2ifd]], [[2ifv]] - hCDC25B catalytic domain (mutant) <br />
**[[2a2k]], [[2ifd]], [[2ifv]] - hCDC25B catalytic domain (mutant) <br />
 +
**[[4wh7]] - hCDC25B catalytic domain (mutant) + ligand<br />
 +
**[[4wh9]] - hCDC25B catalytic domain (mutant) + inhibitor<br />
**[[1cwr]], [[1cws]] - hCDC25B catalytic domain + WO4<BR />
**[[1cwr]], [[1cws]] - hCDC25B catalytic domain + WO4<BR />
**[[1cwt]] - hCDC25B catalytic domain + Methyl-Hg<br />
**[[1cwt]] - hCDC25B catalytic domain + Methyl-Hg<br />

Revision as of 09:31, 29 November 2016

Human tyrosine phosphatase 1B catalytic domain (grey) complex with EGFR peptide (in green), VO4, glycerol, Tris, 2-amino-2-hydroxymethyl-1,3-diol, 3i7z

Drag the structure with the mouse to rotate

3D Structures of tyrosine phosphatase

Updated on 29-November-2016

References

  1. ↑ Paul S, Lombroso PJ. Receptor and nonreceptor protein tyrosine phosphatases in the nervous system. Cell Mol Life Sci. 2003 Nov;60(11):2465-82. PMID:14625689 doi:http://dx.doi.org/10.1007/s00018-003-3123-7
  2. ↑ Caselli A, Paoli P, Santi A, Mugnaioni C, Toti A, Camici G, Cirri P. Low molecular weight protein tyrosine phosphatase: Multifaceted functions of an evolutionarily conserved enzyme. Biochim Biophys Acta. 2016 Oct;1864(10):1339-55. doi:, 10.1016/j.bbapap.2016.07.001. Epub 2016 Jul 13. PMID:27421795 doi:http://dx.doi.org/10.1016/j.bbapap.2016.07.001
  3. ↑ Ostman A, Hellberg C, Bohmer FD. Protein-tyrosine phosphatases and cancer. Nat Rev Cancer. 2006 Apr;6(4):307-20. PMID:16557282 doi:http://dx.doi.org/10.1038/nrc1837

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman

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