Tyrosine phosphatase

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Line 26: Line 26:
**[[1x6c]] - hPTP SHP-1 SH2 domain – NMR<BR />
**[[1x6c]] - hPTP SHP-1 SH2 domain – NMR<BR />
**[[2shp]] - hPTP SHP-2 (mutant)<br />
**[[2shp]] - hPTP SHP-2 (mutant)<br />
-
**[[4qah]], [[4qap]], [[4qbe]], [[4qbw]] – hPTPN1 (mutant)<br />
+
**[[5k9v]] – hPTPN1<br />
 +
**[[4qah]], [[4qap]], [[4qbe]], [[4qbw]], [[5kaa]], [[5ka8]], [[5ka4]], [[5ka2]], [[5ka1]], [[5ka0]] – hPTPN1 (mutant)<br />
**[[2b49]] – hPTPN3 catalytic domain<br />
**[[2b49]] – hPTPN3 catalytic domain<br />
**[[4qun]] – hPTPN3 catalytic domain (mutant) <br />
**[[4qun]] – hPTPN3 catalytic domain (mutant) <br />
Line 44: Line 45:
**[[3b7o]], [[3zm0]], [[3zm1]], [[3zm2]], [[3zm3]] - hPTPN11 catalytic domain<br />
**[[3b7o]], [[3zm0]], [[3zm1]], [[3zm2]], [[3zm3]] - hPTPN11 catalytic domain<br />
**[[4dgp]] - hPTPN11 SH2+catalytic domains<br />
**[[4dgp]] - hPTPN11 SH2+catalytic domains<br />
-
**[[4dgx]], [[4gwf]], [[4h1o]], [[4h34]], [[4nwf]], [[4nwg]], [[4ohd]], [[4ohe]], [[4ohh]], [[4ohi]] - hPTPN11 SH2+catalytic domains (mutant)<br />
+
**[[4dgx]], [[4gwf]], [[4h1o]], [[4h34]], [[4nwf]], [[4nwg]], [[4ohd]], [[4ohe]], [[4ohh]], [[4ohi]], [[4ohl]] - hPTPN11 SH2+catalytic domains (mutant)<br />
**[[5j8r]], [[5i6v]], [[5ibm]], [[5ibs]] - hPTPN11 catalytic domain (mutant)<br />
**[[5j8r]], [[5i6v]], [[5ibm]], [[5ibs]] - hPTPN11 catalytic domain (mutant)<br />
 +
**[[5hde]] - hPTPN12 catalytic domain <br />
**[[5glj]] - hPTPN13 PDZ1 domain <br />
**[[5glj]] - hPTPN13 PDZ1 domain <br />
**[[3lnx]] – hPTPN13 PDZ2 domain<br />
**[[3lnx]] – hPTPN13 PDZ2 domain<br />
Line 52: Line 54:
**[[2oc3]] – hPTPN18<br />
**[[2oc3]] – hPTPN18<br />
**[[2p6x]], [[2qcj]], [[3h2x]] – hPTPN22 catalytic domain<br />
**[[2p6x]], [[2qcj]], [[3h2x]] – hPTPN22 catalytic domain<br />
-
**[[3rau]] - hPTPN23 His domain<br />
+
**[[5cru]], [[5mjz]], [[3rau]] – hRPTP23 domain Bro residues 1-361<br />
-
**[[5cru]] – hRPTP23 domain Bro<br />
+
**[[5lm2]] – hRPTP23 residues 362-713<br />
-
**[[1xm2]] – hPTP PRL-1<br />
+
**[[1xm2]], [[1rxd]] – hPTP PRL-1<br />
-
**[[1r6h]], [[1v3a]], [[2mbc]] – hPTP IVA-3 – NMR<BR />
+
**[[1r6h]], [[1v3a]], [[2mbc]] – hPTP PRL-3 – NMR<BR />
**[[1rxd]] - hPTP IVA-1<br />
**[[1rxd]] - hPTP IVA-1<br />
**[[1zck]], [[1x24]] – rPTP 4A1 – rat<br />
**[[1zck]], [[1x24]] – rPTP 4A1 – rat<br />
Line 62: Line 64:
**[[1d1p]], [[2j16]] – yPTP - yeast<br />
**[[1d1p]], [[2j16]] – yPTP - yeast<br />
**[[2j17]] - yPTP (mutant)<br />
**[[2j17]] - yPTP (mutant)<br />
 +
**[[5xw4]] – yPTPN CDC14 <br />
**[[1g4w]] – StPTP – ''Salmonella typhimurium''<br />
**[[1g4w]] – StPTP – ''Salmonella typhimurium''<br />
**[[2i6i]], [[3ro1]] – SsPTP – ''Sulfolobus solfataricus''<br />
**[[2i6i]], [[3ro1]] – SsPTP – ''Sulfolobus solfataricus''<br />
Line 83: Line 86:
**[[3d42]], [[3d44]] – hPTPN7 catalytic domain (mutant) + peptide<br />
**[[3d42]], [[3d44]] – hPTPN7 catalytic domain (mutant) + peptide<br />
**[[4icz]] – hPTPN9 catalytic domain + peptide<br />
**[[4icz]] – hPTPN9 catalytic domain + peptide<br />
-
**[[3tl0]], [[3tkz]],[[5df6]], [[4qsy]] – hPTPN11 SH2 domain + peptide<br />
+
**[[3tl0]], [[3tkz]],[[5df6]], [[4qsy]],[[5x94]], [[5x7b]] – hPTPN11 SH2 domain + peptide<br />
 +
**[[5o2p]] – hPTPN12 SH3 domain/peptide<br />
**[[3lny]] - hPTPN13 PDZ2 domain + peptide<br />
**[[3lny]] - hPTPN13 PDZ2 domain + peptide<br />
**[[4gfu]], [[4gfv]] - hPTPN18 residues 6-300 + peptide<br />
**[[4gfu]], [[4gfv]] - hPTPN18 residues 6-300 + peptide<br />
Line 89: Line 93:
**[[3brh]], [[3olr]] - hPTPN22 catalytic domain + peptide<br />
**[[3brh]], [[3olr]] - hPTPN22 catalytic domain + peptide<br />
**[[3omh]] - hPTPN22 catalytic domain (mutant) + peptide<br />
**[[3omh]] - hPTPN22 catalytic domain (mutant) + peptide<br />
-
**[[5crv]] – hRPTP23 domain Bro + STAM2 peptide<br />
+
**[[5crv]], [[5mk3]], [[5mk2]], [[5mk1]], [[5mk0]], [[5mjy]] – hRPTP23 domain Bro + STAM2 peptide<br />
 +
**[[5lm2]] – hRPTP23 residues 362-713 + UBAP-1 peptide<br />
**[[3rz2]] - rPTP 4A1 + peptide<br />
**[[3rz2]] - rPTP 4A1 + peptide<br />
**[[1fpr]] - hPTP SHP-1 catalytic domain + peptide<br />
**[[1fpr]] - hPTP SHP-1 catalytic domain + peptide<br />
Line 95: Line 100:
**[[1vj6]] – mPTP PDZ2 domain + APC C terminal – NMR<br />
**[[1vj6]] – mPTP PDZ2 domain + APC C terminal – NMR<br />
**[[2dxp]], [[2i6o]] – SsPTP (mutant) + peptide<br />
**[[2dxp]], [[2i6o]] – SsPTP (mutant) + peptide<br />
 +
**[[5xw5]] – yPTPN CDC14 + SWI6 peptide<br />
*Non-receptor type PTP complex with small molecule
*Non-receptor type PTP complex with small molecule
Line 103: Line 109:
**[[1nwl]], [[1nwe]], [[2fjm]] - hPTP-b catalytic domain (mutant) + inhibitor<br />
**[[1nwl]], [[1nwe]], [[2fjm]] - hPTP-b catalytic domain (mutant) + inhibitor<br />
**[[4bjo]] – hPTP1 catalytic domain + NO3<br />
**[[4bjo]] – hPTP1 catalytic domain + NO3<br />
 +
**[[5t19]], [[5k9w]] – hPTPN1b + inhibitor<br />
 +
**[[5kad]], [[5kac]], [[5kab]], [[5ka9]], [[5ka7]], [[5ka3]] – hPTPN1b (mutant) + inhibitor<br />
**[[4ri4]], [[4ri5]] – hPTPN3 catalytic domain (mutant) + VO4<br />
**[[4ri4]], [[4ri5]] – hPTPN3 catalytic domain (mutant) + VO4<br />
**[[3rgq]] – mPTP-1 + Pi(5)P<br />
**[[3rgq]] – mPTP-1 + Pi(5)P<br />
Line 111: Line 119:
**[[2m10]] - hPTPN13 PDZ2 domain (mutant) + azobenzene derivative – NMR<br />
**[[2m10]] - hPTPN13 PDZ2 domain (mutant) + azobenzene derivative – NMR<br />
**[[2qct]], [[4j51]] – hPTPN22 catalytic domain + inhibitor<br />
**[[2qct]], [[4j51]] – hPTPN22 catalytic domain + inhibitor<br />
 +
**[[5h08]] – hPTP ζ D1 domain + inhibitor<br />
 +
**[[5bx1]] – hPTP PRL-1 + inhibitor<br />
**[[1zcl]] - rPTP 4A1 (mutant) + sulfate<br />
**[[1zcl]] - rPTP 4A1 (mutant) + sulfate<br />
**[[1dg9]] – bPTP + HEPES<br />
**[[1dg9]] – bPTP + HEPES<br />
Line 127: Line 137:
**[[1jyo]] – StPTP + secretion chaperone SICP<br />
**[[1jyo]] – StPTP + secretion chaperone SICP<br />
**[[4je4]], [[4jeg]] – hPTPN11 catalytic domain + monobody<br />
**[[4je4]], [[4jeg]] – hPTPN11 catalytic domain + monobody<br />
 +
**[[5lxq]] – mPTP + CNNM2<br />
 +
**[[5k25]], [[5k24]], [[5k23]] – hPTP PRL-2 + CNNM3<br />
 +
**[[5k22]] – hPTP PRL-2 (mutant) + CNNM3<br />
 +
**[[5tsr]] – hPTP PRL-3 (mutant) + CNNM3<br />
 +
**[[5mmz]] – mPTP 4A1 + CNNM2<br />
**[[4zj7]] – yPTPN CDC14 C terminal + importin<br />
**[[4zj7]] – yPTPN CDC14 C terminal + importin<br />
Line 221: Line 236:
**[[1t3k]] – DUSP (mutant) – ''Arabidopsis thaliana''<br />
**[[1t3k]] – DUSP (mutant) – ''Arabidopsis thaliana''<br />
 +
**[[6apx]] – hDUSP-1/MBP + monobody<br />
**[[2g6z]] – hDUSP-5<br />
**[[2g6z]] – hDUSP-5<br />
**[[4y2e]] – hDUSP-7 (mutant)<br />
**[[4y2e]] – hDUSP-7 (mutant)<br />
Line 253: Line 269:
**[[1z12]] - bLMW-PTP + VO4<br />
**[[1z12]] - bLMW-PTP + VO4<br />
**[[1z13]] - bPTP + MoO4<br />
**[[1z13]] - bPTP + MoO4<br />
 +
**[[5jnw]] – bLMW-PTP + inhibitor <br />
**[[3rof]] – LMW-PTP-A + peptide – ''Staphylococcus aureus''<br />
**[[3rof]] – LMW-PTP-A + peptide – ''Staphylococcus aureus''<br />
**[[1u2q]] – MtLMW-PTP + glycerol<br />
**[[1u2q]] – MtLMW-PTP + glycerol<br />
Line 269: Line 286:
**[[1cwt]] - hCDC25B catalytic domain + Methyl-Hg<br />
**[[1cwt]] - hCDC25B catalytic domain + Methyl-Hg<br />
**[[3op3]] – hCDC25C residues 270-462
**[[3op3]] – hCDC25C residues 270-462
 +
 +
*'''Class IV'''
 +
 +
**[[4tvv]] – PTP – ''Legionella pneumophila''<br />
*'''T-cell tyrosine phosphatase'''
*'''T-cell tyrosine phosphatase'''
Line 279: Line 300:
**[[4r0s]] – PaPTP – ''Pseudomonas aeruginosa''<br />
**[[4r0s]] – PaPTP – ''Pseudomonas aeruginosa''<br />
**[[4r0t]] – PaPTP (mutant) + tyrosine<br />
**[[4r0t]] – PaPTP (mutant) + tyrosine<br />
 +
**[[5ncr]] – PTP (mutant) – ORF virus<br />
}}
}}

Revision as of 11:44, 14 November 2017

Human tyrosine phosphatase 1B catalytic domain (grey) complex with EGFR peptide (in green), VO4, glycerol, Tris, 2-amino-2-hydroxymethyl-1,3-diol, 3i7z

Drag the structure with the mouse to rotate

3D Structures of tyrosine phosphatase

Updated on 14-November-2017

References

  1. ↑ Paul S, Lombroso PJ. Receptor and nonreceptor protein tyrosine phosphatases in the nervous system. Cell Mol Life Sci. 2003 Nov;60(11):2465-82. PMID:14625689 doi:http://dx.doi.org/10.1007/s00018-003-3123-7
  2. ↑ Caselli A, Paoli P, Santi A, Mugnaioni C, Toti A, Camici G, Cirri P. Low molecular weight protein tyrosine phosphatase: Multifaceted functions of an evolutionarily conserved enzyme. Biochim Biophys Acta. 2016 Oct;1864(10):1339-55. doi:, 10.1016/j.bbapap.2016.07.001. Epub 2016 Jul 13. PMID:27421795 doi:http://dx.doi.org/10.1016/j.bbapap.2016.07.001
  3. ↑ Ostman A, Hellberg C, Bohmer FD. Protein-tyrosine phosphatases and cancer. Nat Rev Cancer. 2006 Apr;6(4):307-20. PMID:16557282 doi:http://dx.doi.org/10.1038/nrc1837

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman

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