Sialyltransferase

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(New page: <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> == Function == Sialyltransferase (SIT) is involved in maintaining or increasing cell ...)
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<StructureSection load='2x61' size='340' side='right' caption='Caption for this structure' scene=''>
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<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''>
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== Function ==
== Function ==
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Sialyltransferase (SIT) is involved in maintaining or increasing cell surface sialysation which contribute to adhesive cellular interactions and thus to the growth and differentiation of hematopoietic progenitor cells<ref>PMID:15750786</ref>.
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Sialyltransferase (SIT) is involved in maintaining or increasing cell surface sialysation which contributes to adhesive cellular interactions and thus to the growth and differentiation of hematopoietic progenitor cells<ref>PMID:15750786</ref>.
== Disease ==
== Disease ==
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
{{#tree:id=OrganizedByTopic|openlevels=0|
{{#tree:id=OrganizedByTopic|openlevels=0|
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*Sialyltransferase
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**[[5bo8]] – hSIT - human<br />
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**[[5cxy]] – hSIT + inhibitor <br />
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**[[5bo6]] – hSIT + CDP<br />
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**[[5bo7]] – hSIT + CTP<br />
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**[[5bo9]] – hSIT + sialic acid derivative<br />
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**[[4r83]] – PhdSIT – ''Photobacterium damsela''<br />
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**[[4r84]] – PhdSIT + CMP derivative<br />
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**[[4r9v]] – PhdSIT + gt-b domain<br />
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*Alpha-2,3-sialyltransferase
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**[[4v2u]], [[4v38]], [[4v39]] – PdSIT – ''Pasteurella dagmatis''<br />
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**[[4v3b]], [[4v3c]] – PdSIT + CMP<br />
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**[[2ex0]] – PmSIT - ''Pasteurella multocida''<br />
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**[[3s44]], [[2iy7]], [[2ihj]], [[2ihk]], [[2ex1]] – PmSIT + CMP derivative <br />
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**[[2c84]] – PmSIT + CMP <br />
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**[[2iy8]], [[2ihz]], [[2ilv]] – PmSIT + CMP derivative + lactose<br />
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**[[2ii6]], [[2iib]], [[2iiq]] – PmSIT (mutant) + CMP derivative <br />
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**[[2p2v]], [[2p56]] – CjSIT – ''Campylobacter jejuni''<br />
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**[[2x61]] – CjSIT + sialic acid + CMP <br />
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**[[2x62]], [[2x63]], [[2wqq]], [[2drj]] – CjSIT (mutant) + CMP <br />
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**[[1ro7]], [[1ro8]] – CjSIT + CMP derivative<br />
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}}
== References ==
== References ==
<references/>
<references/>

Revision as of 11:14, 22 December 2016

Caption for this structure

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3D structures of sialyltransferase

Updated on 22-December-2016

References

  1. Schwartz-Albiez R, Merling A, Martin S, Haas R, Gross HJ. Cell surface sialylation and ecto-sialyltransferase activity of human CD34 progenitors from peripheral blood and bone marrow. Glycoconj J. 2004;21(8-9):451-9. PMID:15750786 doi:http://dx.doi.org/10.1007/s10719-004-5535-5
  2. Wang L, Liu Y, Wu L, Sun XL. Sialyltransferase inhibition and recent advances. Biochim Biophys Acta. 2016 Jan;1864(1):143-53. doi: 10.1016/j.bbapap.2015.07.007., Epub 2015 Jul 18. PMID:26192491 doi:http://dx.doi.org/10.1016/j.bbapap.2015.07.007

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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