12-oxophytodienoate reductase
From Proteopedia
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| - | <StructureSection load='' size=' | + | <StructureSection load='' size='400' side='right' caption='Tomato OPR1 complex with FMN (cyan) and 12-oxophytodienoate (green), (PDB code [[1icq]])' scene='71/710043/Cv/6'> |
== Function == | == Function == | ||
| - | '''12-oxophytodienoate reductase''' (OPR) catalyzes the conversion of <scene name='71/710043/Cv/ | + | '''12-oxophytodienoate reductase''' (OPR) catalyzes the conversion of <scene name='71/710043/Cv/11'>12-oxophytodienoate</scene> <span style="color:lime;background-color:black;font-weight:bold;">(green)</span> to 3-oxo-pentenyl-cyclopentane octanoate. The expression of OPR is induced by stimuli like touch, wind, wounding, UV light and detergent. OPR uses the cofactor <scene name='71/710043/Cv/8'>flavin mononucleotide (FMN)</scene> <span style="color:cyan;background-color:black;font-weight:bold;">(cyan)</span> which is reduced by NADPH. <scene name='71/710043/Cv/10'>Click here to see active site</scene>. OPR exhibits self inhibition by dimerization.<ref>PMID:11377202</ref> Three isozymes of OPR are known – OPR1, OPR2, OPR3.<br /> |
* OPR1 cleaves olefinic bonds in α,β-unsaturated carbonyls.<br /> | * OPR1 cleaves olefinic bonds in α,β-unsaturated carbonyls.<br /> | ||
* OPR3 cleaves olefinic bonds in cyclic enones. | * OPR3 cleaves olefinic bonds in cyclic enones. | ||
== Relevance == | == Relevance == | ||
| - | OPR is part of the jasmonic acid synthesis pathway. | + | OPR is part of the jasmonic acid synthesis pathway. Jasmonic acid is regulating plant responses to abiotic and biotic stresses. |
</StructureSection> | </StructureSection> | ||
Revision as of 11:21, 21 March 2018
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3D Structures of 12-oxophytodienoate reductase
Updated on 21-March-2018
References
- ↑ Breithaupt C, Strassner J, Breitinger U, Huber R, Macheroux P, Schaller A, Clausen T. X-ray structure of 12-oxophytodienoate reductase 1 provides structural insight into substrate binding and specificity within the family of OYE. Structure. 2001 May 9;9(5):419-29. PMID:11377202
