Rho-associated protein kinase

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<StructureSection load='' size='450' side='right' caption='Human ROCK1 kinase domain complex with thiazole inhibitor (PDB code [[4yve]])' scene='75/752224/C/1' pspeed='8'>
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<StructureSection load='' size='350' side='right' caption='Human ROCK1 kinase domain complex with thiazole inhibitor (PDB code [[4yve]])' scene='75/752224/C/1' pspeed='8'>
== Function ==
== Function ==
'''Rho-associated protein kinase''' (ROCK) is a Rho GTPase effector. ROCK has been shown to regulate cadherin function and thus cell-cell adhesion<ref>PMID:22031287</ref>. ROCKs phosphorylate a large number of actin-binding proteins to modulate their functions.
'''Rho-associated protein kinase''' (ROCK) is a Rho GTPase effector. ROCK has been shown to regulate cadherin function and thus cell-cell adhesion<ref>PMID:22031287</ref>. ROCKs phosphorylate a large number of actin-binding proteins to modulate their functions.
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{{#tree:id=OrganizedByTopic|openlevels=0|
{{#tree:id=OrganizedByTopic|openlevels=0|
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*Rho-associated protein kinase 1
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*Rho-associated protein kinase 1; domains – kinase 6-415; coiled-coil 535-700; Shroom-binding 834-914; Rho-binding 947-1015
**[[4l2w]] – hROCK1 Shroom-binding domain - human<br />
**[[4l2w]] – hROCK1 Shroom-binding domain - human<br />
**[[3o0z]] – hROCK1 coiled-coil domain <br />
**[[3o0z]] – hROCK1 coiled-coil domain <br />
**[[1uix]] – hROCK1 Rho-binding domain <br />
**[[1uix]] – hROCK1 Rho-binding domain <br />
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**[[5hvu]], [[4yvc]], [[4yve]], [[5bml]], [[4w7p]], [[3twj]], [[3tv7]], [[3v8s]], [[3ncz]], [[3ndm]], [[3d9v]], [[2esm]], [[2etk]], [[2etr]], [[5hvu]], [[5kks]], [[5kkt]], [[4w7p]] – hROCK1 kinase domain + inhibitor <br />
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**[[5hvu]], [[4yvc]], [[4yve]], [[5bml]], [[4w7p]], [[3twj]], [[3tv7]], [[3v8s]], [[3ncz]], [[3ndm]], [[3d9v]], [[2esm]], [[2etk]], [[2etr]], [[5hvu]], [[5kks]], [[5kkt]], [[4w7p]], [[5uzj]], [[5wne]], [[5wnf]], [[5wng]], [[5wnh]] – hROCK1 kinase domain + inhibitor <br />
**[[5f5p]] – hROCK1 Shroom-binding domain + Shroom2 <br />
**[[5f5p]] – hROCK1 Shroom-binding domain + Shroom2 <br />
**[[2v55]] – hROCK1 kinase domain + RhoE + GDP + ANP <br />
**[[2v55]] – hROCK1 kinase domain + RhoE + GDP + ANP <br />

Revision as of 09:02, 6 September 2018

Human ROCK1 kinase domain complex with thiazole inhibitor (PDB code 4yve)

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3D structures of Rho-associated protein kinase

Updated on 06-September-2018

References

  1. ↑ Smith AL, Dohn MR, Brown MV, Reynolds AB. Association of Rho-associated protein kinase 1 with E-cadherin complexes is mediated by p120-catenin. Mol Biol Cell. 2012 Jan;23(1):99-110. doi: 10.1091/mbc.E11-06-0497. Epub 2011 Oct, 26. PMID:22031287 doi:http://dx.doi.org/10.1091/mbc.E11-06-0497
  2. ↑ Schofield AV, Bernard O. Rho-associated coiled-coil kinase (ROCK) signaling and disease. Crit Rev Biochem Mol Biol. 2013 Jul-Aug;48(4):301-16. doi:, 10.3109/10409238.2013.786671. Epub 2013 Apr 19. PMID:23601011 doi:http://dx.doi.org/10.3109/10409238.2013.786671
  3. ↑ Honjo M, Tanihara H, Inatani M, Kido N, Sawamura T, Yue BY, Narumiya S, Honda Y. Effects of rho-associated protein kinase inhibitor Y-27632 on intraocular pressure and outflow facility. Invest Ophthalmol Vis Sci. 2001 Jan;42(1):137-44. PMID:11133858
  4. ↑ Green J, Cao J, Bandarage UK, Gao H, Court J, Marhefka C, Jacobs M, Taslimi P, Newsome D, Nakayama T, Shah S, Rodems S. Design, Synthesis, and Structure-Activity Relationships of Pyridine-Based Rho Kinase (ROCK) Inhibitors. J Med Chem. 2015 Jun 12. PMID:26039570 doi:http://dx.doi.org/10.1021/acs.jmedchem.5b00424

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