Rhodopsin kinase
From Proteopedia
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| - | <StructureSection load='' size=' | + | <StructureSection load='' size='350' side='right' caption='Bovine rhodopsin kinase complex with ATP, Mg+2 and Cl- ions (PDB code [[3c4x]])' scene='70/706261/Cv/1'> |
== Function == | == Function == | ||
'''Rhodopsin kinase''' (RK) is an enzyme which catalyzes the conversion of rhodopsin and ATP to phosphorhodopsin and ADP. RK is retina-specific and the phosphorylation of rhodopsin initiates the phototransduction cascade<ref>PMID:3040978</ref>. The rapid desensitization permits rapid adaptation to changes in illumination. RK is inhibited by the neuronal calcium-binding protein recoverin. | '''Rhodopsin kinase''' (RK) is an enzyme which catalyzes the conversion of rhodopsin and ATP to phosphorhodopsin and ADP. RK is retina-specific and the phosphorylation of rhodopsin initiates the phototransduction cascade<ref>PMID:3040978</ref>. The rapid desensitization permits rapid adaptation to changes in illumination. RK is inhibited by the neuronal calcium-binding protein recoverin. | ||
Revision as of 22:00, 13 September 2018
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3D Structures of rhodopsin kinase
Updated on 13-September-2018
3c4y – bRK – bovine
3t8o – bRK (mutant)
3c4w, 3c4x – bRK + ATP
3c4z, 3c50, 3c51 – bRK + ADP
3qc9 – bRK (mutant) + ADP
4l9i – bRK + paroxetine
4pni – bRK + inhibitor
4wbo – bRK + almexanox
2i94 – bRK + recoverin - NMR
References
- ↑ Kuhn H, Wilden U. Deactivation of photoactivated rhodopsin by rhodopsin-kinase and arrestin. J Recept Res. 1987;7(1-4):283-98. PMID:3040978
- ↑ Yamamoto S, Sippel KC, Berson EL, Dryja TP. Defects in the rhodopsin kinase gene in the Oguchi form of stationary night blindness. Nat Genet. 1997 Feb;15(2):175-8. PMID:9020843 doi:http://dx.doi.org/10.1038/ng0297-175
- ↑ Singh P, Wang B, Maeda T, Palczewski K, Tesmer JJ. Structures of rhodopsin kinase in different ligand states reveal key elements involved in G protein-coupled receptor kinase activation. J Biol Chem. 2008 May 16;283(20):14053-62. Epub 2008 Mar 13. PMID:18339619 doi:10.1074/jbc.M708974200
