Guanylate kinase
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
The biological assembly of ''E. coli'' guanylate kinase is <scene name='48/487529/Cv/9'>homohexamer</scene>. The <scene name='48/487529/Cv/10'>GMP binding site</scene> of GK is <scene name='48/487529/Cv/8'>located between its nucleoside monophosphate-binding domain and the LID domain</scene><ref>PMID:16140325</ref>. | The biological assembly of ''E. coli'' guanylate kinase is <scene name='48/487529/Cv/9'>homohexamer</scene>. The <scene name='48/487529/Cv/10'>GMP binding site</scene> of GK is <scene name='48/487529/Cv/8'>located between its nucleoside monophosphate-binding domain and the LID domain</scene><ref>PMID:16140325</ref>. | ||
| + | |||
| + | ==3D structures of guanylate kinase== | ||
| + | [[Guanylate kinase 3D structures]] | ||
| + | |||
</StructureSection> | </StructureSection> | ||
==3D structures of guanylate kinase== | ==3D structures of guanylate kinase== | ||
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*Guanylate kinase | *Guanylate kinase | ||
| + | **[[6nui]] - hGK - human<br /> | ||
**[[1ex6]], [[4f4j]] – yGK – yeast<br /> | **[[1ex6]], [[4f4j]] – yGK – yeast<br /> | ||
**[[1s4q]], [[1znw]] – MtGK – ''Mycobacterium tuberculosis''<br /> | **[[1s4q]], [[1znw]] – MtGK – ''Mycobacterium tuberculosis''<br /> | ||
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**[[1z6g]] – GK – ''Plasmodium falciparum'' | **[[1z6g]] – GK – ''Plasmodium falciparum'' | ||
| - | *Guanylate kinase | + | *Guanylate kinase complex |
| + | **[[1lvg]] – mGK + ADP + GMP – mouse<br /> | ||
**[[1gky]], [[1ex7]] – yGK + GMP <br /> | **[[1gky]], [[1ex7]] – yGK + GMP <br /> | ||
| - | **[[1lvg]] – GK + ADP + GMP – mouse<br /> | ||
**[[2an9]] – EcGK + guanosine + GDP<br /> | **[[2an9]] – EcGK + guanosine + GDP<br /> | ||
**[[2anb]] – EcGK + GMP<br /> | **[[2anb]] – EcGK + GMP<br /> | ||
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**[[2qor]] - GK + GMP – ''Plasmodium vivax''<br /> | **[[2qor]] - GK + GMP – ''Plasmodium vivax''<br /> | ||
**[[3lnc]] - GK + GMP – ''Anaplasma phagocytophilum''<br /> | **[[3lnc]] - GK + GMP – ''Anaplasma phagocytophilum''<br /> | ||
| - | **[[3tr0]] – GK residues 1-202 + GMP – ''Coxiella burnetii'' | + | **[[3tr0]] – GK residues 1-202 + GMP – ''Coxiella burnetii''<br /> |
| + | **[[6mfu]] - GK + GMP + ADP – ''Cryprococcus neoformans''<br /> | ||
| + | |||
| + | *Membrane-associated guanylate kinase WW and PDZ domain-containing protein 1; Domains – WW 295-388; PDZ1 455-580; PDZ3 640-721; PDZ4 839-922; PDZ6 1149-1233 | ||
| + | |||
| + | **[[2kpk]] – hMAGI-1 PDZ1 – NMR<br /> | ||
| + | **[[3bpu]] – hMAGI-1 PDZ3 (mutant) <br /> | ||
| + | **[[2q9v]] - hMAGI-1 PDZ4 (mutant) <br /> | ||
| + | **[[2r4h]] – hMAGI-1 PDZ6 (mutant) <br /> | ||
| + | **[[2i04]] – hMAGI-1 PDZ1 + papillomavirus peptide<br /> | ||
| + | **[[5n7d]], [[5n7f]], [[5n7g]] - hMAGI-1 PDZ1 + RSK1 peptide<br /> | ||
| + | **[[2kpl]] – hMAGI-1 PDZ1 + protein E6 peptide - NMR<br /> | ||
| + | **[[2ysd]], [[2yse]] – hMAGI-1 WW domain – NMR<br /> | ||
| + | **[[2zaj]] – hMAGI-1 WW domain – NMR<br /> | ||
| + | **[[5zys]] – mMAGI-1 PDZ4 + nephrin<br /> | ||
| + | |||
| + | *Membrane-associated guanylate kinase inverted-2; Domains – PDZ1 454-564; PDZ2 642-724; PDZ3 802-981; PDZ4 943-1043; PDZ5 1169-1258 | ||
| + | |||
| + | **[[1ueq]] – hMAGI-2 PDZ1 – NMR<br /> | ||
| + | **[[1ujv]] – hMAGI-2 PDZ2 – NMR<br /> | ||
| + | **[[1uep]] – hMAGI-2 PDZ3 – NMR<br /> | ||
| + | **[[1uew]] – hMAGI-2 PDZ4 – NMR<br /> | ||
| + | **[[1wfv]] – hMAGI-2 PDZ5 – NMR<br /> | ||
| + | |||
| + | *Membrane-associated guanylate kinase WW and PDZ domain-containing protein 3 | ||
| - | * | + | **[[3soe]] – hMAGI-3 PDZ3 residues 601-691<br /> |
| - | **[[1uep]] – hMAGUK PDZ domain 3 – human – NMR<BR /> | ||
| - | **[[1ueq]], [[2kpk]] - hMAGUK PDZ domain 1 – NMR<BR /> | ||
| - | **[[1ujv]] - hMAGUK PDZ domain 2 – NMR<BR /> | ||
| - | **[[3bpu]] - hMAGUK PDZ domain 3 (mutant)<br /> | ||
| - | **[[3soe]] - hMAGUK PDZ domain 3<br /> | ||
| - | **[[2q9v]] - hMAGUK PDZ domain 4<br /> | ||
| - | **[[1uew]] - hMAGUK PDZ domain 4 – NMR<BR /> | ||
| - | **[[1wfv]] - hMAGUK PDZ domain 5 – NMR<BR /> | ||
| - | **[[2r4h]] - hMAGUK PDZ domain 6 (mutant)<br /> | ||
| - | **[[2i04]] - hMAGUK PDZ domain 1 + papillomavirus peptide<br /> | ||
| - | **[[2kpl]] - hMAGUK PDZ domain 1 + protein E6 peptide]] - NMR<BR /> | ||
| - | **[[2ysd]], [[2yse]] - hMAGUK WW domain – NMR<BR /> | ||
| - | **[[2zaj]] - hMAGUK WW 2 domain – NMR<BR /> | ||
}} | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 09:16, 21 July 2019
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3D structures of guanylate kinase
Updated on 21-July-2019
References
- ↑ Johnston CA, Whitney DS, Volkman BF, Doe CQ, Prehoda KE. Conversion of the enzyme guanylate kinase into a mitotic-spindle orienting protein by a single mutation that inhibits GMP-induced closing. Proc Natl Acad Sci U S A. 2011 Nov 1;108(44):E973-8. Epub 2011 Oct 11. PMID:21990344 doi:10.1073/pnas.1104365108
- ↑ Hible G, Renault L, Schaeffer F, Christova P, Zoe Radulescu A, Evrin C, Gilles AM, Cherfils J. Calorimetric and crystallographic analysis of the oligomeric structure of Escherichia coli GMP kinase. J Mol Biol. 2005 Oct 7;352(5):1044-59. PMID:16140325 doi:10.1016/j.jmb.2005.07.042
