Sialyltransferase
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
The biological assembly of α-2,3-sialyltransferase is <scene name='74/748880/Cv/8'>homotetramer</scene> ([[2x61]]). The <scene name='74/748880/Cv/9'>trisaccharide acceptor binds to the open cleft</scene> at the C-terminal of SIT<ref>PMID:21832050</ref>. <scene name='74/748880/Cv/10'>Trisaccharide binding site</scene>. Water molecules are shown as red spheres. | The biological assembly of α-2,3-sialyltransferase is <scene name='74/748880/Cv/8'>homotetramer</scene> ([[2x61]]). The <scene name='74/748880/Cv/9'>trisaccharide acceptor binds to the open cleft</scene> at the C-terminal of SIT<ref>PMID:21832050</ref>. <scene name='74/748880/Cv/10'>Trisaccharide binding site</scene>. Water molecules are shown as red spheres. | ||
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| + | ==3D structures of sialyltransferase== | ||
| + | [[Sialyltransferase 3D structures]] | ||
</StructureSection> | </StructureSection> | ||
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*Alpha-2,6-sialyltransferase | *Alpha-2,6-sialyltransferase | ||
| - | + | **[[4js1]] – hSIT 1 catalytic domain + cytidine + Pi - human<BR /> | |
| - | **[[4js1]] – hSIT 1 catalytic domain + cytidine + Pi<BR /> | + | |
**[[4js2]] – hSIT 1 catalytic domain + CMP<BR /> | **[[4js2]] – hSIT 1 catalytic domain + CMP<BR /> | ||
| + | **[[6apj]], [[6apl]] – hSIT 2<BR /> | ||
| + | **[[4mps]] – SIT – rat <BR /> | ||
*Alpha-2,8-sialyltransferase | *Alpha-2,8-sialyltransferase | ||
| - | **[[5bo8]] – hSIT | + | **[[5bo8]] – hSIT<br /> |
**[[5cxy]] – hSIT + inhibitor <br /> | **[[5cxy]] – hSIT + inhibitor <br /> | ||
**[[5bo6]] – hSIT + CDP<br /> | **[[5bo6]] – hSIT + CDP<br /> | ||
Revision as of 09:55, 5 February 2020
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3D structures of sialyltransferase
Updated on 05-February-2020
References
- ↑ Schwartz-Albiez R, Merling A, Martin S, Haas R, Gross HJ. Cell surface sialylation and ecto-sialyltransferase activity of human CD34 progenitors from peripheral blood and bone marrow. Glycoconj J. 2004;21(8-9):451-9. PMID:15750786 doi:http://dx.doi.org/10.1007/s10719-004-5535-5
- ↑ Harduin-Lepers A, Vallejo-Ruiz V, Krzewinski-Recchi MA, Samyn-Petit B, Julien S, Delannoy P. The human sialyltransferase family. Biochimie. 2001 Aug;83(8):727-37. PMID:11530204
- ↑ Wang L, Liu Y, Wu L, Sun XL. Sialyltransferase inhibition and recent advances. Biochim Biophys Acta. 2016 Jan;1864(1):143-53. doi: 10.1016/j.bbapap.2015.07.007., Epub 2015 Jul 18. PMID:26192491 doi:http://dx.doi.org/10.1016/j.bbapap.2015.07.007
- ↑ Lee HJ, Lairson LL, Rich JR, Lameignere E, Wakarchuk WW, Withers SG, Strynadka NC. Structural and kinetic analysis of substrate binding to the sialyltransferase CST-II from Campylobacter Jejuni. J Biol Chem. 2011 Aug 8. PMID:21832050 doi:10.1074/jbc.M111.261172
