6um1

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'''Unreleased structure'''
 
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The entry 6um1 is ON HOLD until Paper Publication
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==Structure of M-6-P/IGFII Receptor at pH 4.5==
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<StructureSection load='6um1' size='340' side='right'caption='[[6um1]], [[Resolution|resolution]] 3.46&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6um1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UM1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6UM1 FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6um1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6um1 OCA], [http://pdbe.org/6um1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6um1 RCSB], [http://www.ebi.ac.uk/pdbsum/6um1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6um1 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/MPRI_BOVIN MPRI_BOVIN]] Acts as a positive regulator of T-cell coactivation, by binding DPP4 (By similarity). Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2.
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__TOC__
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</StructureSection>
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[[Category: Bos taurus]]
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[[Category: Large Structures]]
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[[Category: Li, X]]
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[[Category: Qi, X]]
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[[Category: Wang, R]]
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[[Category: Igfii]]
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[[Category: M-6-p]]
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[[Category: Receptor]]
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[[Category: Sugar binding protein]]

Revision as of 09:26, 26 February 2020

Structure of M-6-P/IGFII Receptor at pH 4.5

PDB ID 6um1

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