7e7a
From Proteopedia
(Difference between revisions)
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==Crystal structure of apo ENL YEATS domain T3 mutant== | ==Crystal structure of apo ENL YEATS domain T3 mutant== | ||
| - | <StructureSection load='7e7a' size='340' side='right'caption='[[7e7a]]' scene=''> | + | <StructureSection load='7e7a' size='340' side='right'caption='[[7e7a]], [[Resolution|resolution]] 2.64Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7E7A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7E7A FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7e7a]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7E7A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7E7A FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7e7a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7e7a OCA], [https://pdbe.org/7e7a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7e7a RCSB], [https://www.ebi.ac.uk/pdbsum/7e7a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7e7a ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.64Å</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7e7a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7e7a OCA], [https://pdbe.org/7e7a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7e7a RCSB], [https://www.ebi.ac.uk/pdbsum/7e7a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7e7a ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/ENL_HUMAN ENL_HUMAN] A chromosomal aberration involving MLLT1 is associated with acute leukemias. Translocation t(11;19)(q23;p13.3) with KMT2A/MLL1. The result is a rogue activator protein. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ENL_HUMAN ENL_HUMAN] Component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA.<ref>PMID:20159561</ref> <ref>PMID:20471948</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Li H]] | [[Category: Li H]] | ||
[[Category: Li Y]] | [[Category: Li Y]] | ||
Current revision
Crystal structure of apo ENL YEATS domain T3 mutant
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