Mitogen-activated protein kinase kinase kinase
From Proteopedia
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[[Mitogen-activated protein kinase kinase kinase]] or '''DLK''' (MAP3K) are serine/threonine kinases which regulate various cellular activities in response to extracellular stimuli by mitogens, heat shock and more. MAP3K is part of the MAPK cascade which consists also of [[Mitogen-activated protein kinase|MAPK]] and [[Mitogen-activated protein kinase kinase|MAP2K]] which are activated by phosphorylation. MAP3K activates [[Mitogen-activated protein kinase kinase|MAP2K]]<ref>PMID:9006902</ref>. | [[Mitogen-activated protein kinase kinase kinase]] or '''DLK''' (MAP3K) are serine/threonine kinases which regulate various cellular activities in response to extracellular stimuli by mitogens, heat shock and more. MAP3K is part of the MAPK cascade which consists also of [[Mitogen-activated protein kinase|MAPK]] and [[Mitogen-activated protein kinase kinase|MAP2K]] which are activated by phosphorylation. MAP3K activates [[Mitogen-activated protein kinase kinase|MAP2K]]<ref>PMID:9006902</ref>. | ||
*'''MAP3K1''' regulates cell migration and contributes to pro-survival signaling<ref>PMID:24386504</ref>. | *'''MAP3K1''' regulates cell migration and contributes to pro-survival signaling<ref>PMID:24386504</ref>. | ||
| + | *'''MAP3K10''' has a role in the tumorugenesis of pancreatic ductal adenocarcinoma<ref>PMID:23178452</ref>. | ||
== Disease == | == Disease == | ||
Revision as of 10:14, 11 July 2024
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3D Structures of Mitogen-activated protein kinase kinase kinase
Updated on 11-July-2024
References
- ↑ Ellinger-Ziegelbauer H, Brown K, Kelly K, Siebenlist U. Direct activation of the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by an inducible mitogen-activated protein Kinase/ERK kinase kinase 3 (MEKK) derivative. J Biol Chem. 1997 Jan 31;272(5):2668-74. PMID:9006902
- ↑ Pham TT, Angus SP, Johnson GL. MAP3K1: Genomic Alterations in Cancer and Function in Promoting Cell Survival or Apoptosis. Genes Cancer. 2013 Nov;4(11-12):419-26. PMID:24386504 doi:10.1177/1947601913513950
- ↑ An Y, Cai B, Chen J, Lv N, Yao J, Xue X, Tu M, Tang D, Wei J, Jiang K, Wu J, Li Q, Gao W, Miao Y. MAP3K10 promotes the proliferation and decreases the sensitivity of pancreatic cancer cells to gemcitabine by upregulating Gli-1 and Gli-2. Cancer Lett. 2013 Feb 28;329(2):228-35. PMID:23178452 doi:10.1016/j.canlet.2012.11.005
- ↑ Santen RJ, Song RX, McPherson R, Kumar R, Adam L, Jeng MH, Yue W. The role of mitogen-activated protein (MAP) kinase in breast cancer. J Steroid Biochem Mol Biol. 2002 Feb;80(2):239-56. PMID:11897507
