User:Kristen Russo/Sandbox2 1N25
From Proteopedia
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==Introduction== | ==Introduction== | ||
| - | Large T-antigen (LTag) is a viral [http://www.merriam-webster.com/medical/oncoprotein oncoprotein] derived from the polyomavirus SV40 (Simian virus 40). | + | Large T-antigen (LTag) is a viral [http://www.merriam-webster.com/medical/oncoprotein oncoprotein] derived from the polyomavirus SV40 (Simian virus 40). SV40 was first identified in the cultures of Asian rhesus monkeys in 1960. SV40 infects primate cells by forcing its way into the cells and releasing its DNA. Once inside, the DNA replicates and packages it in new viral capsids. SV40 uses the T-antigen protein to control both of these processes. There are three functional parts to the T-antigen. The first part is the LTag, which forms a six-fold ring by assembling with several other copies of the protein. The hole in the middle encircles a DNA double helix. |
Revision as of 06:36, 24 April 2012
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Introduction
Large T-antigen (LTag) is a viral oncoprotein derived from the polyomavirus SV40 (Simian virus 40). SV40 was first identified in the cultures of Asian rhesus monkeys in 1960. SV40 infects primate cells by forcing its way into the cells and releasing its DNA. Once inside, the DNA replicates and packages it in new viral capsids. SV40 uses the T-antigen protein to control both of these processes. There are three functional parts to the T-antigen. The first part is the LTag, which forms a six-fold ring by assembling with several other copies of the protein. The hole in the middle encircles a DNA double helix.
