NADH:ubiquinone oxidoreductase
From Proteopedia
(Difference between revisions)
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Complex I is the first enzyme of the electron transport chain. This enzyme is one of the three large chains of protein complexes that electrons are transferred through. For every molecule of oxidized NADH, this complex translocates four protons across the inner membrane. This helps build the electrochemical potential used to produce ATP. The reaction of this complex is NADH + Q + 5H+matrix → NAD+ + QH2 + 4H+cytoplasm | Complex I is the first enzyme of the electron transport chain. This enzyme is one of the three large chains of protein complexes that electrons are transferred through. For every molecule of oxidized NADH, this complex translocates four protons across the inner membrane. This helps build the electrochemical potential used to produce ATP. The reaction of this complex is NADH + Q + 5H+matrix → NAD+ + QH2 + 4H+cytoplasm | ||
| - | == | + | == Structure == |
| + | NADH-Q oxidoreductase consists of approximately 46 polypeptide chains (>900kd). The genes encoding this proton pump resides in both the mitochondria and the nucleus. This enzyme is L-shaped, with a horizontal arm lying the membrane and a vertical arm that projects into the matrix. | ||
| - | == | + | == Disease == |
== Structural highlights == | == Structural highlights == | ||
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</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
| - | < | + | <Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644/> |
Revision as of 04:10, 21 April 2014
Structure
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References
<Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644/>
