Tripeptidyl peptidase
From Proteopedia
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[[Image:2d5l.png|left|200px|thumb|Crystal Structure of Tripeptidyl peptidase ([[2d5l]])]] | [[Image:2d5l.png|left|200px|thumb|Crystal Structure of Tripeptidyl peptidase ([[2d5l]])]] | ||
| - | {{STRUCTURE_3ee6| PDB=3ee6 | SIZE=400| SCENE= |right|CAPTION= | + | {{STRUCTURE_3ee6| PDB=3ee6 | SIZE=400| SCENE= |right|CAPTION=Glycosylated tripeptidyl peptidase dimer complex with sulfate, Zn+2 (grey), Ca+2 (green) and Cl- (green) ions, [[3ee6]]}} |
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| - | [[Tripeptidyl peptidase]] (TPP) is an enzyme which cleaves N-terminal tripeptides from polypeptides. TPP-I functions in lysosomes | + | [[Tripeptidyl peptidase]] (TPP) is an enzyme which cleaves N-terminal tripeptides from polypeptides.<br /> |
| + | * '''TPP-I''' functions in lysosomes.<br /> | ||
| + | * '''TPP-II''' is part of the ubiquitin-proteasome pathway. <br /> | ||
| + | * '''TPP-IV''' is a serine exopeptidase which cleaves proline dipeptides from the N-terminus of polypeptides. | ||
== 3D Structures of Tripeptidyl peptidase == | == 3D Structures of Tripeptidyl peptidase == | ||
Revision as of 08:09, 21 August 2014
Image:2d5l.png
Crystal Structure of Tripeptidyl peptidase (2d5l)
Tripeptidyl peptidase (TPP) is an enzyme which cleaves N-terminal tripeptides from polypeptides.
- TPP-I functions in lysosomes.
- TPP-II is part of the ubiquitin-proteasome pathway.
- TPP-IV is a serine exopeptidase which cleaves proline dipeptides from the N-terminus of polypeptides.
Contents |
3D Structures of Tripeptidyl peptidase
TPP-I
3ee6 – TPP-I – human
3edy – hTPP-I precursor residues 20-563
TPP-II
3lxu – TPP-II residues 463-770 – Drosophila melanogaster
TPP-IV
2eep – PgPro-TPP-IV+inhibitor – Porphyromonas gingivalis
2d5l - PgPro-TPP-IV
2z3w - PgPro-TPP-IV (mutant)
2z3z, 2dcm - PgPro-TPP-IV (mutant)+inhibitor
