Sandbox TATA Binding Protein Austin McCauley

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Function

TATA binding protein(TBP) is one of several proteins which make up the RNA polymerase complex used in transcription. Specifically the TBP belongs to the TFIID complex containing a variety of transcription factors contributing to success of transcription for the RNA polymerase complex. TBP is involved in all three RNA polymerase complexes, making TBP an essential initiation factor in transcription. (BIOCHEMISTRY AND STRUCTURAL BIOLOGY OF TRANSCRIPTION FACTOR IID (TFIID)) The TFIID focuses on binding to the DNA used in transcription. The TBP's main function is to bind with the TATA box of the DNA in order to anchor the protein to the TFIID complex, thus allowing for RNA II polymerase to carry out transcription. (TATA element recognition by the TATA box-binding protein has been conserved throughout evolution) The importance of the TBP in the RNA polymerase complex stems from the RNA polymerase complex's inability to recognize the target promoter directly. The TBP binds to the TATA sequence approximately 25 base pairs upstream the start site of the DNA.(BIOCHEMISTRY AND STRUCTURAL BIOLOGY OF TRANSCRIPTION FACTOR IID (TFIID))

Interaction with DNA

Key Structures

Structural highlights