Guanylate kinase

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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
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[[1ex6]], [[4f4j]] – yGK – yeast<br />
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*Guanylate kinase
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[[3sqk]] – yGK (mutant)<br />
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[[1s4q]], [[1znw]] – MtGK – ''Mycobacterium tuberculosis''<br />
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-
[[1z8f]] – MtGK (mutant)<br />
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-
[[1s96]], [[2anc]] – EcGK – ''Escherichia coli''<br />
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[[1z6g]] – GK – ''Plasmodium falciparum''
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===Guanylate kinase binary complex===
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**[[1ex6]], [[4f4j]] – yGK – yeast<br />
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**[[3sqk]] – yGK (mutant)<br />
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**[[1s4q]], [[1znw]] – MtGK – ''Mycobacterium tuberculosis''<br />
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**[[1z8f]] – MtGK (mutant)<br />
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**[[1s96]], [[2anc]] – EcGK – ''Escherichia coli''<br />
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**[[1z6g]] – GK – ''Plasmodium falciparum''
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[[1gky]], [[1ex7]] – yGK + GMP <br />
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*Guanylate kinase binary complex
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[[1lvg]] – GK + ADP + GMP – mouse<br />
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-
[[2an9]] – EcGK + guanosine + GDP<br />
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[[2anb]] – EcGK + GMP<br />
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[[2f3t]] – EcGK + GMP derivative<br />
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[[2f3r]] – EcGK + adenosyl-guanosyl pentaphosphate<br />
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[[1znx]] – MtGK + GMP<br />
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[[1zny]], [[1znz]] – MtGK + GDP<br />
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[[2j41]] – GK + GMP – ''Staphylococcus aureus''<br />
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-
[[2qor]] - GK + GMP – ''Plasmodium vivax''<br />
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-
[[3lnc]] - GK + GMP – ''Anaplasma phagocytophilum''<br />
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[[3tr0]] – GK residues 1-202 + GMP – ''Coxiella burnetii''
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===Membrane-associated guanylate kinase===
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**[[1gky]], [[1ex7]] – yGK + GMP <br />
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**[[1lvg]] – GK + ADP + GMP – mouse<br />
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**[[2an9]] – EcGK + guanosine + GDP<br />
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**[[2anb]] – EcGK + GMP<br />
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**[[2f3t]] – EcGK + GMP derivative<br />
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**[[2f3r]] – EcGK + adenosyl-guanosyl pentaphosphate<br />
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**[[1znx]] – MtGK + GMP<br />
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**[[1zny]], [[1znz]] – MtGK + GDP<br />
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**[[2j41]] – GK + GMP – ''Staphylococcus aureus''<br />
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**[[2qor]] - GK + GMP – ''Plasmodium vivax''<br />
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**[[3lnc]] - GK + GMP – ''Anaplasma phagocytophilum''<br />
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**[[3tr0]] – GK residues 1-202 + GMP – ''Coxiella burnetii''
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[[1uep]] – hMAGUK PDZ domain 3 – human – NMR<BR />
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*Membrane-associated guanylate kinase
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[[1ueq]], [[2kpk]] - hMAGUK PDZ domain 1 – NMR<BR />
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[[1ujv]] - hMAGUK PDZ domain 2 – NMR<BR />
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[[3bpu]] - hMAGUK PDZ domain 3 (mutant)<br />
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[[3soe]] - hMAGUK PDZ domain 3<br />
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[[2q9v]] - hMAGUK PDZ domain 4<br />
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[[1uew]] - hMAGUK PDZ domain 4 – NMR<BR />
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[[1wfv]] - hMAGUK PDZ domain 5 – NMR<BR />
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[[2r4h]] - hMAGUK PDZ domain 6 (mutant)<br />
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[[2i04]] - hMAGUK PDZ domain 1 + papillomavirus peptide<br />
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[[2kpl]] - hMAGUK PDZ domain 1 + protein E6 peptide]] - NMR<BR />
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[[2ysd]], [[2yse]] - hMAGUK WW domain – NMR<BR />
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-
[[2zaj]] - hMAGUK WW 2 domain – NMR<BR />
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**[[1uep]] – hMAGUK PDZ domain 3 – human – NMR<BR />
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**[[1ueq]], [[2kpk]] - hMAGUK PDZ domain 1 – NMR<BR />
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**[[1ujv]] - hMAGUK PDZ domain 2 – NMR<BR />
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**[[3bpu]] - hMAGUK PDZ domain 3 (mutant)<br />
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**[[3soe]] - hMAGUK PDZ domain 3<br />
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**[[2q9v]] - hMAGUK PDZ domain 4<br />
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**[[1uew]] - hMAGUK PDZ domain 4 – NMR<BR />
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**[[1wfv]] - hMAGUK PDZ domain 5 – NMR<BR />
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**[[2r4h]] - hMAGUK PDZ domain 6 (mutant)<br />
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**[[2i04]] - hMAGUK PDZ domain 1 + papillomavirus peptide<br />
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**[[2kpl]] - hMAGUK PDZ domain 1 + protein E6 peptide]] - NMR<BR />
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**[[2ysd]], [[2yse]] - hMAGUK WW domain – NMR<BR />
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**[[2zaj]] - hMAGUK WW 2 domain – NMR<BR />
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}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 07:12, 27 November 2014

Template:STRUCTURE 1gky

Guanylate kinase (GK) catalyzes the transfer of phosphate from GMP to GDP using ATP as a phosphate source. GK is essential for recycling GMP and cGMP. GK also forms a domain in the membrane-associated GK (MAGUK) which functions in mitotic spindle orientation and cell adhesion. There is a single mutation in GK which converts it to a GK domain. The GK domain has no catalytic activity. The MAGUK contain PDZ, WW, SH3 and GK domains.

3D structures of guanylate kinase

Updated on 27-November-2014

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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