This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
Phosphodiesterase
From Proteopedia
(Difference between revisions)
| Line 179: | Line 179: | ||
**[[3qvq]] – PDE + glycerol-3-phosphate – ''Oleispira antarctica''<br /> | **[[3qvq]] – PDE + glycerol-3-phosphate – ''Oleispira antarctica''<br /> | ||
**[[4b2o]] – PDE – ''Bacillus subtilis''<br /> | **[[4b2o]] – PDE – ''Bacillus subtilis''<br /> | ||
| - | **[[4g75]], [[4g76]] – | + | **[[4g75]], [[4g76]] – PaPDE <br /> |
}} | }} | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 08:35, 12 May 2015
- 3'5'-cyclic nucleotide phosphodiesterases (PDE) are enzymes that hydrolyze the 3',5'-phosphodiester bond in cyclic nucleotides (e.g., cAMP, cGMP). PDEs operate in concert with cyclases (adenylate cyclase or guanylate cyclase) to regulate the cellular concentration of cyclic nucleotides. cAMP and cGMP serve as intracellular second messengers for a multitude of signaling pathways, including sensory transduction, hormone signaling, and neurotransmitter signaling. In mammals, 11 distinct families of PDEs have been identified which share a highly homologous catalytic domain (pfam:00233, PDEase_I). See details on PDE 6 in User:Rick H. Cote/PDE6.
- Tyrosyl-DNA PDE hydrolyzes phosphodiester bond at the 3’-end of DNA linked to a tyrosyl moiety.
- Glycerophosphodiester PDE hydrolyzes various glycerophosphodiesters to release glycerol-3-phosphate and alcohol.
Specific phosphodiesterases are in C-di-GMP specific phosphodiesterases.
3D Structures of phosphodiesterase
Updated on 12-May-2015
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Alexander Berchansky, Joel L. Sussman, Rick H. Cote
