Tyrosine phosphatase

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Line 23: Line 23:
**[[1x6c]] - hPTP SHP-1 SH2 domain – NMR<BR />
**[[1x6c]] - hPTP SHP-1 SH2 domain – NMR<BR />
**[[2shp]] - hPTP SHP-2 (mutant)<br />
**[[2shp]] - hPTP SHP-2 (mutant)<br />
 +
**[[4qah]], [[4qap]], [[4qbe]], [[4qbw]] – hPTPN1 (mutant)<br />
**[[2b49]] – hPTPN3 catalytic domain<br />
**[[2b49]] – hPTPN3 catalytic domain<br />
 +
**[[4qun]] – hPTPN3 catalytic domain (mutant) <br />
**[[2i75]] – hPTPN4<br />
**[[2i75]] – hPTPN4<br />
**[[2cs5]] – hPTPN4 PDZ domain – NMR<BR />
**[[2cs5]] – hPTPN4 PDZ domain – NMR<BR />
Line 39: Line 41:
**[[3b7o]], [[3zm0]], [[3zm1]], [[3zm2]], [[3zm3]] - hPTPN11 catalytic domain<br />
**[[3b7o]], [[3zm0]], [[3zm1]], [[3zm2]], [[3zm3]] - hPTPN11 catalytic domain<br />
**[[4dgp]] - hPTPN11 SH2+catalytic domains<br />
**[[4dgp]] - hPTPN11 SH2+catalytic domains<br />
-
**[[4dgx]], [[4gwf]], [[4h1o]], [[4h34]] - hPTPN11 SH2+catalytic domains (mutant)<br />
+
**[[4dgx]], [[4gwf]], [[4h1o]], [[4h34]], [[4nwf]], [[4nwg]], [[4ohd]], [[4ohe]], [[4ohh]], [[4ohi]] - hPTPN11 SH2+catalytic domains (mutant)<br />
**[[3lnx]] – hPTPN13 PDZ2 domain<br />
**[[3lnx]] – hPTPN13 PDZ2 domain<br />
**[[2m0z]] - hPTPN13 PDZ2 domain (mutant) – NMR<br />
**[[2m0z]] - hPTPN13 PDZ2 domain (mutant) – NMR<br />
Line 66: Line 68:
**[[1ptt]], [[1ptu]], [[1g1f]], [[1g1g]], [[1g1h]], [[1een]], [[1eeo ]] - hPTP-b catalytic domain (mutant) + peptide<br />
**[[1ptt]], [[1ptu]], [[1g1f]], [[1g1g]], [[1g1h]], [[1een]], [[1eeo ]] - hPTP-b catalytic domain (mutant) + peptide<br />
**[[3i7z]] - hPTP-b catalytic domain + peptide<br />
**[[3i7z]] - hPTP-b catalytic domain + peptide<br />
-
**[[3zmp]], [[3zmq]] – hPTPN1 catalytic domain + peptide<br />
+
**[[3zmp]], [[3zmq]], [[4zrt]] – hPTPN1 catalytic domain + peptide<br />
 +
**[[4qum]], [[4rh5]], [[4rh9]], [[4rhg]], [[4s0g]] – hPTPN3 catalytic domain (mutant) + peptide<br />
**[[1bzh]] - hPTP 1B catalytic domain + fluoromalonyl tyrosine peptide<br />
**[[1bzh]] - hPTP 1B catalytic domain + fluoromalonyl tyrosine peptide<br />
**[[1bzj]] - hPTP 1B catalytic domain + phosphotyrosine mimetic<br />
**[[1bzj]] - hPTP 1B catalytic domain + phosphotyrosine mimetic<br />
Line 77: Line 80:
**[[3lny]] - hPTPN13 PDZ2 domain + peptide<br />
**[[3lny]] - hPTPN13 PDZ2 domain + peptide<br />
**[[4gfu]], [[4gfv]] - hPTPN18 residues 6-300 + peptide<br />
**[[4gfu]], [[4gfv]] - hPTPN18 residues 6-300 + peptide<br />
 +
**[[4nnd]] - hPTPN18 residues 6-300 (mutant) + ERBB-2<br />
**[[3brh]], [[3olr]] - hPTPN22 catalytic domain + peptide<br />
**[[3brh]], [[3olr]] - hPTPN22 catalytic domain + peptide<br />
**[[3omh]] - hPTPN22 catalytic domain (mutant) + peptide<br />
**[[3omh]] - hPTPN22 catalytic domain (mutant) + peptide<br />
Line 92: Line 96:
**[[1nwl]], [[1nwe]], [[2fjm]] - hPTP-b catalytic domain (mutant) + inhibitor<br />
**[[1nwl]], [[1nwe]], [[2fjm]] - hPTP-b catalytic domain (mutant) + inhibitor<br />
**[[4bjo]] – hPTP1 catalytic domain + NO3<br />
**[[4bjo]] – hPTP1 catalytic domain + NO3<br />
 +
**[[4ri4]], [[4ri5]] – hPTPN3 catalytic domain (mutant) + VO4<br />
**[[3rgq]] – mPTP-1 + Pi(5)P<br />
**[[3rgq]] – mPTP-1 + Pi(5)P<br />
**[[2cjz]] - hPTPN5 catalytic domain (mutant) + phosphotyrosine<br />
**[[2cjz]] - hPTPN5 catalytic domain (mutant) + phosphotyrosine<br />
**[[4ge2]], [[4ge5]], [[4ge6]] – hPTP9 catalytic domain + inhibitor<br />
**[[4ge2]], [[4ge5]], [[4ge6]] – hPTP9 catalytic domain + inhibitor<br />
-
**[[3o5x]] – hPTPN11 catalytic domain + inhibitor<br />
+
**[[3o5x]], [[4pvg]] – hPTPN11 catalytic domain + inhibitor<br />
**[[3mow]] - hPTPN11 catalytic domain + tautomycetin analog<br />
**[[3mow]] - hPTPN11 catalytic domain + tautomycetin analog<br />
**[[2m10]] - hPTPN13 PDZ2 domain (mutant) + azobenzene derivative – NMR<br />
**[[2m10]] - hPTPN13 PDZ2 domain (mutant) + azobenzene derivative – NMR<br />
Line 115: Line 120:
**[[1jyo]] – StPTP + secretion chaperone SICP<br />
**[[1jyo]] – StPTP + secretion chaperone SICP<br />
**[[4je4]], [[4jeg]] – hPTPN11 catalytic domain + monobody<br />
**[[4je4]], [[4jeg]] – hPTPN11 catalytic domain + monobody<br />
 +
**[[4zj7]] – yPTPN CDC14 C terminal + importin<br />
*'''Yersinia tyrosine phosphatase Yop'''
*'''Yersinia tyrosine phosphatase Yop'''
Line 141: Line 147:
**[[1p15]] - mRPTP-α D2 domain<br />
**[[1p15]] - mRPTP-α D2 domain<br />
**[[3pxh]] - mRPTP Ig domains<br />
**[[3pxh]] - mRPTP Ig domains<br />
 +
**[[1jln]], [[2a8b]] - mRPTP-R catalytic domain<br />
 +
**[[3sr9]] - mRPTP-σ residues 1326 – 1901<br />
**[[2nv5]] – RPRP - rat<br />
**[[2nv5]] – RPRP - rat<br />
 +
**[[2yd4]] - cRPTP-σ Ig1-2 domain – chicken<br />
 +
**[[2yd1]], [[2yd2]], [[3pxj]] – DmRPTP Ig1-2 domain – ''Drosophila melanogaster''<br />
 +
**[[3s3e]] – DmRPTP-10D catalytic domain<br />
 +
 +
*'''Human receptor-type tyrosine phosphatase'''
 +
**[[2ahs]] – hRPTP-β<br />
**[[2ahs]] – hRPTP-β<br />
**[[2i3r]], [[2i5x]] - hRPTP-β catalytic domain<br />
**[[2i3r]], [[2i5x]] - hRPTP-β catalytic domain<br />
Line 151: Line 165:
**[[3jxh]] - hRPTP-γ CA-like domain<br />
**[[3jxh]] - hRPTP-γ CA-like domain<br />
**[[1x5z]] - hRPTP-δ fibronectin type-III domain – NMR<BR />
**[[1x5z]] - hRPTP-δ fibronectin type-III domain – NMR<BR />
 +
**[[4yfe]] - hRPTP-δ FN1-FN2 domain<br />
 +
**[[4yfg]] - hRPTP-δ Ig1-FN1 domain<br />
**[[2dlh]] - hRPTP-δ FN3 domain – NMR<BR />
**[[2dlh]] - hRPTP-δ FN3 domain – NMR<BR />
**[[2yd6]], [[2yd7]] - hRPTP-δ Ig1-2 domain<br />
**[[2yd6]], [[2yd7]] - hRPTP-δ Ig1-2 domain<br />
Line 168: Line 184:
**[[2yd9]] - hRPTP-σ Ig1-3 domain (mutant) <br />
**[[2yd9]] - hRPTP-σ Ig1-3 domain (mutant) <br />
**[[2yd3]], [[2yd5]] - hRPTP-σ Ig1-2 domain<br />
**[[2yd3]], [[2yd5]] - hRPTP-σ Ig1-2 domain<br />
-
**[[2yd4]] - cRPTP-σ Ig1-2 domain – chicken<br />
+
**[[4pbx]] - hRPTP-σ residues 30-588<br />
**[[3jxf]] - hRPTP-ζ CA-like domain<br />
**[[3jxf]] - hRPTP-ζ CA-like domain<br />
**[[2qt7]], [[3n01]], [[3n4w]], [[3ng8]], [[3np5]] – hRPTP IA-2<br />
**[[2qt7]], [[3n01]], [[3n4w]], [[3ng8]], [[3np5]] – hRPTP IA-2<br />
-
**[[1jln]], [[2a8b]] - mRPTP-R catalytic domain<br />
+
**[[4n5u]] - hRPTP-F fibronectin type-III domain<br />
-
**[[3sr9]] - mRPTP-σ residues 1326 – 1901<br />
+
**[[2edx]] - hRPTP-F fibronectin type-III domain – NMR<BR />
**[[2edx]] - hRPTP-F fibronectin type-III domain – NMR<BR />
-
**[[2yd1]], [[2yd2]], [[3pxj]] – DmRPTP Ig1-2 domain – ''Drosophila melanogaster''<br />
 
-
**[[3s3e]] – DmRPTP-10D catalytic domain<br />
 
*Receptor type tyrosine phosphatase complexes
*Receptor type tyrosine phosphatase complexes
Line 188: Line 201:
**[[3qcl]], [[3qcm]] - hRPTP-γ domain 1 (mutant) + inhibitor<br />
**[[3qcl]], [[3qcm]] - hRPTP-γ domain 1 (mutant) + inhibitor<br />
**[[3kld]] - mRPTP-γ CA-like domain + contactin 4<br />
**[[3kld]] - mRPTP-γ CA-like domain + contactin 4<br />
 +
**[[4rca]], [[4y61]] - hRPTP-δ + SLITRK1<br />
 +
**[[4yfc]], [[4yfd]], [[4yh7]] - hRPTP-δ + IL1RAPL1<br />
**[[2yd8]] - hRPTP-σ Ig1-2 domain + sucrose octasulfate<br />
**[[2yd8]] - hRPTP-σ Ig1-2 domain + sucrose octasulfate<br />
**[[3s97]] - hRPTP-ζ CA-like domain + congtactin Ig domains<br />
**[[3s97]] - hRPTP-ζ CA-like domain + congtactin Ig domains<br />
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**[[1t3k]] – DUSP (mutant) – ''Arabidopsis thaliana''<br />
**[[1t3k]] – DUSP (mutant) – ''Arabidopsis thaliana''<br />
-
**[[2g6z]] – DUSP-5<br />
+
**[[2g6z]] – hDUSP-5<br />
-
**[[3lj8]] – DUSP-9<br />
+
**[[3lj8]] – hDUSP-9<br />
 +
**[[4jnb]], [[4ki9]] – hDUSP-12 catalytic domain (mutant)<br />
**[[2wgp]] – hDUSP-14 residues 2-191
**[[2wgp]] – hDUSP-14 residues 2-191
Line 231: Line 247:
**[[1l8k]] – hTC-PTP
**[[1l8k]] – hTC-PTP
 +
 +
*'''Other tyrosine phosphatases'''
**[[4az1]] – PTP – ''Trypanosoma cruzi''<br />
**[[4az1]] – PTP – ''Trypanosoma cruzi''<br />
 +
**[[4r0s]] – PaPTP – ''Pseudomonas aeruginosa''<br />
 +
**[[4r0t]] – PaPTP (mutant) + tyrosine<br />
 +
}}
}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 07:58, 24 June 2015

Template:STRUCTURE 3i7z

Tyrosine phosphatase (PTP) is an enzyme which removes phosphate from phosphorylated tyrosine residues. It is a key regulatory component of signal transduction pathways. PTPs are divided to 4 subfamilies. PTP class I contains receptor PTPs (RPTP) and dual-specificity PTP which removes phosphate from Ser/Thr and tyrosine. PTP class III contains CDC25 which removes phosphate from Thr and tyrosine. PTP containing SH2 domains are called PTP SHP. For details on Yersinia PTP see Yersinia YopH.

3D Structures of tyrosine phosphatase

Updated on 24-June-2015

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman

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