12-oxophytodienoate reductase
From Proteopedia
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<StructureSection load='1icq' size='340' side='right' caption='Tomato OPR1 complex with FMN (cyan) and 12-oxophytodienoate (green), (PDB code [[1icq]])' scene='71/710043/Cv/1'> | <StructureSection load='1icq' size='340' side='right' caption='Tomato OPR1 complex with FMN (cyan) and 12-oxophytodienoate (green), (PDB code [[1icq]])' scene='71/710043/Cv/1'> | ||
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| + | == Function == | ||
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'''12-oxophytodienoate reductase''' (OPR) catalyzes the conversion of <scene name='71/710043/Cv/2'>12-oxophytodienoate</scene> <span style="color:lime;background-color:black;font-weight:bold;">(green)</span> to 3-oxo-pentenyl-cyclopentane octanoate. The expression of OPR is induced by stimuli like touch, wind, wounding, UV light and detergent. OPR uses the cofactor <scene name='71/710043/Cv/4'>flavin mononucleotide (FMN)</scene> <span style="color:cyan;background-color:black;font-weight:bold;">(cyan)</span> which is reduced by NADPH. <scene name='71/710043/Cv/5'>Click here to see active site</scene>. OPR exhibits self inhibition by dimerization. Three isozymes of OPR are known – OPR1, OPR2, OPR3.<br /> | '''12-oxophytodienoate reductase''' (OPR) catalyzes the conversion of <scene name='71/710043/Cv/2'>12-oxophytodienoate</scene> <span style="color:lime;background-color:black;font-weight:bold;">(green)</span> to 3-oxo-pentenyl-cyclopentane octanoate. The expression of OPR is induced by stimuli like touch, wind, wounding, UV light and detergent. OPR uses the cofactor <scene name='71/710043/Cv/4'>flavin mononucleotide (FMN)</scene> <span style="color:cyan;background-color:black;font-weight:bold;">(cyan)</span> which is reduced by NADPH. <scene name='71/710043/Cv/5'>Click here to see active site</scene>. OPR exhibits self inhibition by dimerization. Three isozymes of OPR are known – OPR1, OPR2, OPR3.<br /> | ||
* OPR1 cleaves olefinic bonds in α,β-unsaturated carbonyls.<br /> | * OPR1 cleaves olefinic bonds in α,β-unsaturated carbonyls.<br /> | ||
* OPR3 cleaves olefinic bonds in cyclic enones. | * OPR3 cleaves olefinic bonds in cyclic enones. | ||
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| - | == Function == | ||
| - | OPR is part of the jasmonic acid synthesis pathway. Jasmonic acid is regulating plant responses to abiotic and biotic stresses. | ||
| - | == Disease == | ||
== Relevance == | == Relevance == | ||
| - | + | OPR is part of the jasmonic acid synthesis pathway. Jasmonic acid is regulating plant responses to abiotic and biotic stresses. | |
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</StructureSection> | </StructureSection> | ||
Revision as of 07:32, 25 October 2015
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3D Structures of 12-oxophytodienoate reductase
Updated on 25-October-2015
