Calcium/Calmodulin-dependent protein kinase

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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
{{#tree:id=OrganizedByTopic|openlevels=0|
- 
-
* CaMKK – CaM kinase kinase
 
- 
-
**[[1iq5]] – CeCaMK CBD+XlCaM – ''Xenopus laevis''<br />
 
* CaMKI – specialized CaM kinase
* CaMKI – specialized CaM kinase
-
**[[1mxe]] – rCaMKI CBD+CaM – rat<br />
+
**[[1a06]] – rCaMK - rat<br />
-
**[[1ckk]] – rCaMK CBD chain B+XlCaM<br />
+
**[[3nyv]], [[3n51]], [[3i7b]], [[3i7c]], [[3hzt]] – TgCaMK + inhibitor – ''Toxoplasma gondii''<br />
-
**[[1a06]] – rCaMK chain A<br />
+
**[[3ku2]], [[3i79]] - TgCaMK <br />
 +
**[[3khe]] – TgCaMK residues 345-535 + Ca<br />
 +
**[[3hx4]] – TgCaMK+Ca<br />
 +
**[[3dxn]], [[3is5]] – TgCaMK kinase domain + Ca<br />
 +
**[[3mwu]] – CpCaMK (mutant)+ inhibitor + Ca – ''Cryptosporidium parvum''<br />
 +
**[[3ncg]] - CpCaMK + inhibitor + Ca <br />
 +
**[[3igo]] - CpCaMK +Ca <br />
 +
**[[3hko]] - CpCaMK kinase domain residues 125-452 + Zn<br />
 +
**[[2qg5]], [[3dfa]] – CpCaMK kinase domain<br />
 +
**[[3f3z]] – CpCaMK kinase domain+indirubin_E804<br />
 +
**[[2aao]] – CaMK C terminal + Ca – ''Arabidopsis thaliana''<br />
 +
**[[1s6j]], [[1s6i]] – sCaMK α residues 329-402 + Ca – soybean - NMR<br />
* CASK – membrane-associated CaMK
* CASK – membrane-associated CaMK
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**[[3kl8]] – CeCaMKII (mutant)+inhibitor<br />
**[[3kl8]] – CeCaMKII (mutant)+inhibitor<br />
**[[3ksp]] – CaMKII ASD – ''Exiguobacterium sibiricum''<br />
**[[3ksp]] – CaMKII ASD – ''Exiguobacterium sibiricum''<br />
 +
**[[3pm8]] – PfCaMKII CBD + Ca – ''Plasmodium falciparum'' <br />
 +
**[[4mvf]] – PfCaMKII + Ca + staurosporine <br />
 +
 +
*CaMKIII
 +
 +
**[[3lij]] – CpCaMKIII +Ca<br />
 +
**[[3l19]], [[3hko]] – CpCaMKIII CBD + Ca<br />
 +
**[[3k21]] – PfCaMKIII C terminal + Ca <br />
 +
**[[3jwq]] – CaMKIII C terminal + Ca – ''Plasmodium berhei'' <br />
 +
**[[3o4y]] – CaMKIII C terminal + Ca – ''Plasmodium vivax'' <br />
* CaMKIV
* CaMKIV
**[[2w4o]] – hCaMKIV+inhibitor<br />
**[[2w4o]] – hCaMKIV+inhibitor<br />
 +
**[[4rgj]] – PfCaMKIV <br />
 +
**[[4qox]] – PfCaMKIV + Mg <br />
 +
}}
}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 11:13, 15 November 2015

Template:STRUCTURE 3mfr

Contents

Function

Ca2+/Calmodulin dependent protein kinase (CaMK) are activated by elevation of Ca+2 and calmodulin concentration to phosphorylate Ser and Thr.

  • CaMKI is a specialized CaM kinase.
  • CaMKII is multifunctional kinase.
  • CASK is a membrane associated CaMK.
  • DAPK is a death-associated CaMK which protects cells from some programmed cell death.

Structural highlights

CAMKII contains an N-terminal catalytic domain which binds ATP and substrate protein, regulatory domain (CBD) and association domain (ASD). DAPK contains a regulatory (RD) and autoinhibitory (AD) domains.

3D Structures of Ca2+/Calmodulin dependent protein kinase

Updated on 15-November-2015

See also

Calcium-dependent protein kinase, a member of the CaM kinase family

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Alice Harmon, Jaime Prilusky

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