Collagenase (non-MMP)

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<StructureSection load='4arf' size='350' side='right' caption='Collagenase H peptidase domain (grey) complex with peptidic inhibitor (green), isopentenyl phosphate, Ca+2 (green) and Zn+2 (grey) ions (PDB entry [[4arf]])' scene=''>
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<StructureSection load='4arf' size='350' side='right' caption='Collagenase H peptidase domain (cyan) complex with peptidic inhibitor, isopentenyl phosphate, Ca+2 (green) and Zn+2 (grey) ions (PDB entry [[4arf]])' scene='47/477092/Cv/1'>
'''Collagenase''' (Col) catalyzes the breaking of peptide bonds in collagen. Col cleaves pro-collagen to create collagen. Some collagenases are part of the [[Matrix metalloproteinase]] family. <ref>PMID:23703618</ref>
'''Collagenase''' (Col) catalyzes the breaking of peptide bonds in collagen. Col cleaves pro-collagen to create collagen. Some collagenases are part of the [[Matrix metalloproteinase]] family. <ref>PMID:23703618</ref>

Revision as of 10:12, 20 December 2015

Collagenase H peptidase domain (cyan) complex with peptidic inhibitor, isopentenyl phosphate, Ca+2 (green) and Zn+2 (grey) ions (PDB entry 4arf)

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3D Structures of collagenase

Updated on 20-December-2015

References

  1. Eckhard U, Schonauer E, Brandstetter H. Structural basis for activity regulation and substrate preference of clostridial collagenases G, H, and T. J Biol Chem. 2013 May 23. PMID:23703618 doi:10.1074/jbc.M112.448548

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Michal Harel, Alexander Berchansky

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