Collagenase (non-MMP)
From Proteopedia
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<StructureSection load='4arf' size='350' side='right' caption='Collagenase H peptidase domain (cyan) complex with peptidic inhibitor, isopentenyl phosphate, Ca+2 (green) and Zn+2 (grey) ions (PDB entry [[4arf]])' scene='47/477092/Cv/1'> | <StructureSection load='4arf' size='350' side='right' caption='Collagenase H peptidase domain (cyan) complex with peptidic inhibitor, isopentenyl phosphate, Ca+2 (green) and Zn+2 (grey) ions (PDB entry [[4arf]])' scene='47/477092/Cv/1'> | ||
| - | '''Collagenase''' (Col) catalyzes the breaking of peptide bonds in collagen. Col cleaves pro-collagen to create collagen. Some collagenases are part of the [[Matrix metalloproteinase]] family. | + | '''Collagenase''' (Col) catalyzes the breaking of peptide bonds in collagen. Col cleaves pro-collagen to create collagen. Some collagenases are part of the [[Matrix metalloproteinase]] family. |
== Relevance == | == Relevance == | ||
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== Structural highlights == | == Structural highlights == | ||
| - | ''Clostridium histolycum'' collagenase contains several domains among them: peptidase domain (residues 331-721), polycystic kidney disease domain (PKD residues 792-880), collagen-binding domain (CBD residues 1003-1118). The peptidase domain contains a <scene name='47/477092/Cv/3'>Zn+2 coordination site</scene>, a <scene name='47/477092/Cv/4'>substrate-recognition site</scene> and an <scene name='47/477092/Cv/6'>oxyanion hole</scene>. | + | ''Clostridium histolycum'' collagenase contains several domains among them: peptidase domain (residues 331-721), polycystic kidney disease domain (PKD residues 792-880), collagen-binding domain (CBD residues 1003-1118). The peptidase domain contains a <scene name='47/477092/Cv/3'>Zn+2 coordination site</scene>, a <scene name='47/477092/Cv/4'>substrate-recognition site</scene> and an <scene name='47/477092/Cv/6'>oxyanion hole</scene>.<ref>PMID:23703618</ref> <scene name='47/477092/Cv/7'>Click here to see surface of binding site</scene>. |
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Revision as of 11:30, 20 December 2015
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3D Structures of collagenase
Updated on 20-December-2015
References
- ↑ Eckhard U, Schonauer E, Brandstetter H. Structural basis for activity regulation and substrate preference of clostridial collagenases G, H, and T. J Biol Chem. 2013 May 23. PMID:23703618 doi:10.1074/jbc.M112.448548
