Poly (ADP-ribose) polymerase
From Proteopedia
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{{STRUCTURE_3l3l| PDB=3l3l | SIZE=400| SCENE= |right|CAPTION=Poly (ADP-ribose) polymerase complex with inhibitor [[3l3l]] }} | {{STRUCTURE_3l3l| PDB=3l3l | SIZE=400| SCENE= |right|CAPTION=Poly (ADP-ribose) polymerase complex with inhibitor [[3l3l]] }} | ||
== Function == | == Function == | ||
| - | [[Poly (ADP-ribose) polymerase]] '''(PARP)''' is involved in DNA repair and programmed cell death. The PARP family contains 17 members. PARP is composed of 4 domains. Among them are the N terminal DNA-binding domain which contains 2 zinc fingers; auto modification domain which contains a WGR-rich domain; C terminal which includes the catalytic domain (or PARP domain). PARP-10 contains a RNA recognition motif (RRM). '''Tankyrase (Tank)''' is a PARP which contains ankyrin repeats (a 33-residue repeat with 2 α-helices separated by loops). | + | [[Poly (ADP-ribose) polymerase]] '''(PARP)''' is involved in DNA repair and programmed cell death. The PARP family contains 17 members. PARP is composed of 4 domains. Among them are the N terminal DNA-binding domain which contains 2 zinc fingers; auto modification domain which contains a WGR-rich domain; C terminal which includes the catalytic domain (or PARP domain). |
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| + | *'''PARP-1''' and '''PARP-2''' recognize and is activated by DNA breaks<ref>PMID:10856830</ref>, <ref>PMID:14749375</ref>.<br /> | ||
| + | *'''PARP-3''' prevents from extensive end resection to promote double-strand DNA repair <ref>PMID:25017100</ref>.<br /> | ||
| + | *'''PARP-10''' contains a RNA recognition motif (RRM).<br /> | ||
| + | *'''Tankyrase (Tank)''' is a PARP which contains ankyrin repeats (a 33-residue repeat with 2 α-helices separated by loops). | ||
== 3D Structures of Poly (ADP-ribose) polymerase == | == 3D Structures of Poly (ADP-ribose) polymerase == | ||
Revision as of 10:15, 5 July 2016
Function
Poly (ADP-ribose) polymerase (PARP) is involved in DNA repair and programmed cell death. The PARP family contains 17 members. PARP is composed of 4 domains. Among them are the N terminal DNA-binding domain which contains 2 zinc fingers; auto modification domain which contains a WGR-rich domain; C terminal which includes the catalytic domain (or PARP domain).
- PARP-1 and PARP-2 recognize and is activated by DNA breaks[1], [2].
- PARP-3 prevents from extensive end resection to promote double-strand DNA repair [3].
- PARP-10 contains a RNA recognition motif (RRM).
- Tankyrase (Tank) is a PARP which contains ankyrin repeats (a 33-residue repeat with 2 α-helices separated by loops).
3D Structures of Poly (ADP-ribose) polymerase
Updated on 05-July-2016
