Sialyltransferase

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Revision as of 10:29, 22 December 2016

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spinqualitylabelsall models Caption for this structure Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Contents 1 Function 2 Disease 3 Relevance 4 Structural highlights Function Sialyltransferase (SIT) is involved in maintaining or increasing cell surface sialysation which contribute to adhesive cellular interactions and thus to the growth and differentiation of hematopoietic progenitor cells[1]. Disease Relevance Elevated SIT activity leads to overexpression of cell surface sialic acids and contributes to many disease developments such as cancer and inflammation[2]. Structural highlights

3D structures of sialyltransferase

Updated on 22-December-2016 {{#tree:id=OrganizedByTopic|openlevels=0|

References

1. ↑ Schwartz-Albiez R, Merling A, Martin S, Haas R, Gross HJ. Cell surface sialylation and ecto-sialyltransferase activity of human CD34 progenitors from peripheral blood and bone marrow. Glycoconj J. 2004;21(8-9):451-9. PMID:15750786 doi:http://dx.doi.org/10.1007/s10719-004-5535-5
2. ↑ Wang L, Liu Y, Wu L, Sun XL. Sialyltransferase inhibition and recent advances. Biochim Biophys Acta. 2016 Jan;1864(1):143-53. doi: 10.1016/j.bbapap.2015.07.007., Epub 2015 Jul 18. PMID:26192491 doi:http://dx.doi.org/10.1016/j.bbapap.2015.07.007