Sialyltransferase

From Proteopedia

Revision as of 15:10, 22 December 2016

spinqualitylabelsall models α-2,3-sialyltransferase complex with trisaccharide, acetate, MPD and ethylene glycol (PDB code 2x61) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Function Sialyltransferase (SIT) is involved in maintaining or increasing cell surface sialysation which contributes to adhesive cellular interactions and thus to the growth and differentiation of hematopoietic progenitor cells[1]. Relevance Elevated SIT activity leads to overexpression of cell surface sialic acids and contributes to many disease developments such as cancer and inflammation[2]. Structural highlights The biological assembly of α-2,3-sialyltransferase is (2x61). The trisaccharide acceptor binds to the open cleft at the C-terminal of SIT[3].

3D structures of sialyltransferase

Updated on 22-December-2016

References

1. ↑ Schwartz-Albiez R, Merling A, Martin S, Haas R, Gross HJ. Cell surface sialylation and ecto-sialyltransferase activity of human CD34 progenitors from peripheral blood and bone marrow. Glycoconj J. 2004;21(8-9):451-9. PMID:15750786 doi:http://dx.doi.org/10.1007/s10719-004-5535-5
2. ↑ Wang L, Liu Y, Wu L, Sun XL. Sialyltransferase inhibition and recent advances. Biochim Biophys Acta. 2016 Jan;1864(1):143-53. doi: 10.1016/j.bbapap.2015.07.007., Epub 2015 Jul 18. PMID:26192491 doi:http://dx.doi.org/10.1016/j.bbapap.2015.07.007
3. ↑ Lee HJ, Lairson LL, Rich JR, Lameignere E, Wakarchuk WW, Withers SG, Strynadka NC. Structural and kinetic analysis of substrate binding to the sialyltransferase CST-II from Campylobacter Jejuni. J Biol Chem. 2011 Aug 8. PMID:21832050 doi:10.1074/jbc.M111.261172