Gramicidin Channel in Lipid Bilayer

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Revision as of 16:17, 28 June 2017

Theoretical Model: The structure described on this page was determined theoretically (in 1994[1]), and hence should be interpreted with caution.

spinqualitylabelsall models Theoretical model of gramicidin in a lipid bilayer (phosphatidyl ethanolamine). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Two copies of the 15-amino-acid gramicidin peptide are shown here () arranged as they are believed to be when they form a channel through a lipid bilayer membrane^[1]. The shape of the protein is shown with tiny dots, inside of which is a ribbon backbone trace connecting the alpha carbon atoms of each amino acid chain.

• Show of the gramicidin protein chains. The chains are covalently linked with dioxane in this experiment (C, O),
• (Most hydrogen atoms are omitted.)
  C, H, O, N, P.
• Show . Notice how the hydrophobic lipid "tails" exclude water.
• Water passes .

• Show .

• Show only .
  C, H, O, N, P.
  For an explanation of their structure, see the detailed tutorial, also disponible en español.

Remember to use the popup button and then resize the popup window to enlarge the molecular scenes.

See Also

• A detailed explanation and tutorial about Lipid Bilayers and the Gramicidin Channel.
• This model in FirstGlance in Jmol. Be sure to click the Ligands+ and Water buttons!
• Lipids: structure and classification
• BioMolecular Explorer 3D, a resource for high school teachers that includes a section on gramicidin in a lipid bilayer.
• High school teachers' resources
• The Spanish version of this page: Canal de gramicidina en bicapa lipídica (Spanish)
• For additional information, see: Membrane Channels & Pumps

Notes

• The PDB file shown here, Image:Gramicidin in bilayer.pdb.gz, was kindly provided by Serge Crouzy^[1].

References

1. ↑ ^{1.0 1.1 1.2} Crouzy S, Woolf TB, Roux B. A molecular dynamics study of gating in dioxolane-linked gramicidin A channels. Biophys J. 1994 Oct;67(4):1370-86. PMID:7529578 doi:http://dx.doi.org/10.1016/S0006-3495(94)80618-6