Spermidine/spermine N-acetyltransferase
From Proteopedia
(Difference between revisions)
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| - | <StructureSection load='' size=' | + | <StructureSection load='' size='350' side='right' scene='48/486363/Cv/2' caption='Human SSAT1 dimer complex with acetyl-spermine-S-CoA, [[2jev]]'> |
== Function == | == Function == | ||
'''Spermidine/spermine N-acetyltransferase''' (SSAT) or '''Spermidine N-acetyltransferase''' catalyzes the acetylation of spermidine and spermine. SSAT regulates cellular polyamine homeostasis by degrading polyamines via their acetylation. SSAT activity is regulated by polyamine concentration and various toxins, hormones and natural products<ref>PMID:18349109</ref>. | '''Spermidine/spermine N-acetyltransferase''' (SSAT) or '''Spermidine N-acetyltransferase''' catalyzes the acetylation of spermidine and spermine. SSAT regulates cellular polyamine homeostasis by degrading polyamines via their acetylation. SSAT activity is regulated by polyamine concentration and various toxins, hormones and natural products<ref>PMID:18349109</ref>. | ||
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**[[2f5i]], [[2b5g]], [[2g3t]] – hSSAT1<br /> | **[[2f5i]], [[2b5g]], [[2g3t]] – hSSAT1<br /> | ||
**[[2b3u]] – hSSAT1 (mutant)<br /> | **[[2b3u]] – hSSAT1 (mutant)<br /> | ||
| - | **[[5cnp]], [[5ug4]] – VcSSAT – ''Vibrio cholerae''<br /> | + | **[[5cnp]], [[5ug4]], [[6cx8]] – VcSSAT – ''Vibrio cholerae''<br /> |
| - | **[[4r9m]] – SSAT – ''Escherichia coli''<br /> | + | **[[6dau]] – VcSSAT (mutant)<br /> |
| - | + | **[[4r9m]], [[6cy6]] – SSAT – ''Escherichia coli''<br /> | |
| + | **[[6d72]] – YpSSAT - ''Yersinia pestis''<br /> | ||
*Spermidine/spermine N-acetyltransferase complexes | *Spermidine/spermine N-acetyltransferase complexes | ||
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**[[4r87]] – VcSSAT + spermine + CoA <br /> | **[[4r87]] – VcSSAT + spermine + CoA <br /> | ||
**[[4ncz]] – VcSSAT + sulfonate derivative<br /> | **[[4ncz]] – VcSSAT + sulfonate derivative<br /> | ||
| - | **[[5wif]] – | + | **[[5wif]] – YpSSAT + methoxy-methoxy–ethoxy-ethane <br /> |
}} | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 19:53, 20 September 2018
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3D structures of SSAT
20-September-2018
References
- ↑ Pegg AE. Spermidine/spermine-N(1)-acetyltransferase: a key metabolic regulator. Am J Physiol Endocrinol Metab. 2008 Jun;294(6):E995-1010. doi:, 10.1152/ajpendo.90217.2008. Epub 2008 Mar 18. PMID:18349109 doi:http://dx.doi.org/10.1152/ajpendo.90217.2008
- ↑ Allen WL, McLean EG, Boyer J, McCulla A, Wilson PM, Coyle V, Longley DB, Casero RA Jr, Johnston PG. The role of spermidine/spermine N1-acetyltransferase in determining response to chemotherapeutic agents in colorectal cancer cells. Mol Cancer Ther. 2007 Jan;6(1):128-37. PMID:17237273 doi:http://dx.doi.org/10.1158/1535-7163.MCT-06-0303
- ↑ Hegde SS, Chandler J, Vetting MW, Yu M, Blanchard JS. Mechanistic and structural analysis of human spermidine/spermine N1-acetyltransferase. Biochemistry. 2007 Jun 19;46(24):7187-95. Epub 2007 May 22. PMID:17516632 doi:10.1021/bi700256z
