Thioredoxin Reductase

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Line 24: Line 24:
**[[4zn0]] – TrxR – ''Methanosarcina mazei''<br />
**[[4zn0]] – TrxR – ''Methanosarcina mazei''<br />
**[[4xrd]], [[4xs1]], [[4xs4]], [[4xs6]], [[5uka]], [[4xts]], [[4xra]] – TrxR (mutant) – ''Salmonella enterica''<br />
**[[4xrd]], [[4xs1]], [[4xs4]], [[4xs6]], [[5uka]], [[4xts]], [[4xra]] – TrxR (mutant) – ''Salmonella enterica''<br />
 +
**[[6bwt]] – TrxR - ''Francisella tularensis''<br />
*Thioredoxin reductase complex with FAD
*Thioredoxin reductase complex with FAD
Line 40: Line 41:
**[[5uth]] – TrxR + FAD – ''Mycobacterium smegmatis''<br />
**[[5uth]] – TrxR + FAD – ''Mycobacterium smegmatis''<br />
**[[5uwy]] – TrxR + FAD – ''Streptococcus pyogenes''<br />
**[[5uwy]] – TrxR + FAD – ''Streptococcus pyogenes''<br />
 +
**[[5uwy]] – TrxR + FAD – ''Cypptococcus neoformans''<br />
*Thioredoxin reductase complex with FAD and NADP
*Thioredoxin reductase complex with FAD and NADP
Line 53: Line 55:
**[[4a65]] - EhTrxR+FAD+NADPH + Au<br />
**[[4a65]] - EhTrxR+FAD+NADPH + Au<br />
**[[4ccq]] - EhTrxR+NADPH<br />
**[[4ccq]] - EhTrxR+NADPH<br />
-
**[[4gcm]] - TrxR+FAD+NADPH – ''Staphylococcus aureus''<br />
+
**[[4gcm]] - SaTrxR+FAD+NADPH – ''Staphylococcus aureus''<br />
**[[5mh4]], [[5mjk]], [[5mip]], [[5miq]], [[5mir]], [[5mis]], [[5mit]] – TrxR + FAD + NAPD – ''Lactococcus lactis''<br />
**[[5mh4]], [[5mjk]], [[5mip]], [[5miq]], [[5mir]], [[5mis]], [[5mit]] – TrxR + FAD + NAPD – ''Lactococcus lactis''<br />
**[[5usx]], [[5vt3]] – VvTrxR + FAD + NAPD <br />
**[[5usx]], [[5vt3]] – VvTrxR + FAD + NAPD <br />
Line 71: Line 73:
**[[1zdl]], [[1zkq]] – mTrxR-2+FAD+NADPH – mouse<br />
**[[1zdl]], [[1zkq]] – mTrxR-2+FAD+NADPH – mouse<br />
-
**[[3dgz]] – mTrxR-2+FAD<br />
+
**[[3dgz]] – mTrxR-2 + FAD<br />
 +
**[[6a4j]] – SaTrxR-2 + FAD<br />
**[[2whd]] – TrxR-2+FAD – ''Hordeum vulgare''<br />
**[[2whd]] – TrxR-2+FAD – ''Hordeum vulgare''<br />
**[[4j56]], [[4j57]] - PfTrxR-2 (mutant) + Trx (mutant) +FAD<br />
**[[4j56]], [[4j57]] - PfTrxR-2 (mutant) + Trx (mutant) +FAD<br />

Revision as of 20:57, 25 September 2018

Human Thioredoxin reductase dimer (cyan, green) complex with thioredoxin (yellow, pink), glycerol and FAD (PDB entry 3qfa)

Drag the structure with the mouse to rotate

3D Structures of Thioredoxin Reductase

Updated on 25-September-2018

References

  1. Arner ES, Holmgren A. Physiological functions of thioredoxin and thioredoxin reductase. Eur J Biochem. 2000 Oct;267(20):6102-9. PMID:11012661
  2. Prasad R, Chan LF, Hughes CR, Kaski JP, Kowalczyk JC, Savage MO, Peters CJ, Nathwani N, Clark AJ, Storr HL, Metherell LA. Thioredoxin Reductase 2 (TXNRD2) mutation associated with familial glucocorticoid deficiency (FGD). J Clin Endocrinol Metab. 2014 Aug;99(8):E1556-63. doi: 10.1210/jc.2013-3844. Epub, 2014 Mar 6. PMID:24601690 doi:http://dx.doi.org/10.1210/jc.2013-3844
  3. Fritz-Wolf K, Kehr S, Stumpf M, Rahlfs S, Becker K. Crystal structure of the human thioredoxin reductase-thioredoxin complex. Nat Commun. 2011 Jul 12;2:383. doi: 10.1038/ncomms1382. PMID:21750537 doi:10.1038/ncomms1382

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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