Twinfilin
From Proteopedia
(Difference between revisions)
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| - | <StructureSection load='3daw' size='340' side='right' caption= | + | <StructureSection load='3daw' size='340' side='right' caption=Structure of twinfilin-1 C-terminal ADF-H domain (green) complex with actin (grey), ATP and Ca+2 ion (green (PDB code [[3daw]])' scene=''> |
== Function == | == Function == | ||
'''Twinfilin''' (Twi) is an actin-monomer-binding protein which is composed of 2 Actin Depolimerizing Factor Homology (ADF-H) domains. Twi forms a 1:1 complex with ADP-actin-monomer, inhibits nucleotide exchange on actin monomers and prevents assembly of the monomer to filaments<ref>PMID:11870207</ref>. | '''Twinfilin''' (Twi) is an actin-monomer-binding protein which is composed of 2 Actin Depolimerizing Factor Homology (ADF-H) domains. Twi forms a 1:1 complex with ADP-actin-monomer, inhibits nucleotide exchange on actin monomers and prevents assembly of the monomer to filaments<ref>PMID:11870207</ref>. | ||
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| - | == Disease == | ||
== Relevance == | == Relevance == | ||
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| + | Twi-1 is highly induced by stimulation of amino acids (Met and Leu) and hormones(estrogen and prolactin) and involved in regulation of milk biosynthesis<ref>PMID:28864421</ref>. | ||
== Structural highlights == | == Structural highlights == | ||
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</StructureSection> | </StructureSection> | ||
| - | ==3D structures of | + | ==3D structures of twinfilin== |
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
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[[2hd7]], [[2d8b]] – mTwi-1 C-terminal ADF-H domain – mouse - NMR<br /> | [[2hd7]], [[2d8b]] – mTwi-1 C-terminal ADF-H domain – mouse - NMR<br /> | ||
[[1m4j]] – mTwi-1 N-terminal ADF-H domain <br /> | [[1m4j]] – mTwi-1 N-terminal ADF-H domain <br /> | ||
| - | [[3daw]] – Twi-1 C-terminal ADF-H domain (mutant) + actin - rabbit<br /> | + | [[3daw]] – Twi-1 C-terminal ADF-H domain (mutant) + actin + ATP - rabbit<br /> |
[[2vac]] – hTwi-2 N-terminal ADF-H domain - human<br /> | [[2vac]] – hTwi-2 N-terminal ADF-H domain - human<br /> | ||
[[2w0i]] – hTwi-2 C-terminal ADF-H domain (mutant) <br /> | [[2w0i]] – hTwi-2 C-terminal ADF-H domain (mutant) <br /> | ||
Revision as of 10:21, 31 December 2018
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3D structures of twinfilin
Updated on 31-December-2018
Domains: N-terminal ADF-H 1-142; C-terminal ADF-H 176-316
2hd7, 2d8b – mTwi-1 C-terminal ADF-H domain – mouse - NMR
1m4j – mTwi-1 N-terminal ADF-H domain
3daw – Twi-1 C-terminal ADF-H domain (mutant) + actin + ATP - rabbit
2vac – hTwi-2 N-terminal ADF-H domain - human
2w0i – hTwi-2 C-terminal ADF-H domain (mutant)
References
- ↑ Palmgren S, Vartiainen M, Lappalainen P. Twinfilin, a molecular mailman for actin monomers. J Cell Sci. 2002 Mar 1;115(Pt 5):881-6. PMID:11870207
- ↑ Li L, Liu L, Qu B, Li X, Gao X, Zhang M. Twinfilin 1 enhances milk bio-synthesis and proliferation of bovine mammary epithelial cells via the mTOR signaling pathway. Biochem Biophys Res Commun. 2017 Oct 21;492(3):289-294. doi:, 10.1016/j.bbrc.2017.08.130. Epub 2017 Aug 31. PMID:28864421 doi:http://dx.doi.org/10.1016/j.bbrc.2017.08.130
